The Molecular and Cellular Basis of Neurodegenerative Diseases - 1st Edition - ISBN: 9780128113042, 9780128113059

The Molecular and Cellular Basis of Neurodegenerative Diseases

1st Edition

Underlying Mechanisms

Editors: Michael S. Wolfe
eBook ISBN: 9780128113059
Hardcover ISBN: 9780128113042
Imprint: Academic Press
Published Date: 4th April 2018
Page Count: 560
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The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common.

This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field.

Key Features

  • Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features
  • Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration
  • Details features, advantages and limitations of animal models, as well as prospects for therapeutic development
  • Authored by internationally recognized leaders in the field
  • Includes illustrations that help clarify and consolidate complex concepts


Graduate students in biological and biomedical sciences, neuroscientists, neurobiologists, neuropathologists, biological psychiatrists, post-doctoral fellows, researchers

Table of Contents

1. General Overview
  Michael S. Wolfe
2. Prion Diseases
  Robert C.C. Mercer, Alex J. McDonald, Erin Bove-Fenderson, Cheng Fang, Bei Wu and David Harris
3. Alzheimer’s disease: towards a quantitative biological approach in describing its natural history and underlying mechanisms
  Colin Masters
4. Neurodegeneration and the ordered assembly of Tau
  Michael Goedert
5. ALS and Other TDP43 Proteinopathies
  Christopher Shaw and Jorge Gomez-Deza
6. Parkinson’s Disease and Other Synucleinopathies
  Mark R. Cookson
7. Huntington’s Disease and Other Polyglutamine Disorders
  Albert R. La Spada and Audrey Dickey
8. Prion-like propagation in Neurodegenerative Diseases
  Patrik Brundin, Veerle Baekelandt and Wouter Peelaerts
9. Neurodegenerative Diseases as Protein Folding Disorders
  Jack Mathew Webster
10. Heat shock proteins and protein quality control in Alzheimer's disease
  Fred van Leeuwen and Harm H. Kampinga
11. Neurodegenerative Diseases and Autophagy
  David C. Rubinsztein
12. Neurodegenerative Diseases and Axonal Transport
  Larry Goldstein and Utpal Das
13. Mitochondrial Function and Neurodegenerative Diseases
  Russell Swerdlow
14. Neurodegenerative Diseases and Non-cell autonomous toxicity
  Azad Bonni
15. Neurodegenerative Diseases and RNA-mediated toxicity
  Tiffany Todd and Leonard Petrucelli
16. Neuroinflammation in Age-Related Neurodegenerative Diseases
  Kathryn MacPherson, Maria Elizabeth de Sousa Rodrigues, Amarallys F. Cintron and Malú G. Tansey
17. Neurodegenerative Diseases and the Aging Brain
  Stephen Kenneth Godin, Jinsoo Seo, and Li-Huei Tsai


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© Academic Press 2018
Academic Press
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About the Editor

Michael S. Wolfe

Michael S. Wolfe is the Mathias P. Mertes Professor of Medicinal Chemistry at the University of Kansas. He received his B.S. in chemistry in 1984 from the Philadelphia College of Pharmacy and Science and Ph.D. in medicinal chemistry in 1990 from the University of Kansas. After postdoctoral stints at the University of Kansas (medicinal chemistry) and the NIH (cell biology), he joined the faculty of the University of Tennessee in Memphis in 1994. In 1999, he joined the faculty at Brigham and Women’s Hospital and Harvard Medical School in Boston, becoming Professor of Neurology in 2008. Prof. Wolfe’s work has focused on understanding the molecular basis of Alzheimer’s disease and related disorders, and identifying effective approaches for pharmacological intervention. Awards for his work include the Sato Memorial International Award in bioorganic and medicinal chemistry from the Pharmaceutical Society of Japan (2003), the MetLife Award for Biomedical Research (2008), a Zenith Fellows Award from the Alzheimer’s Association (2008), and the Potamkin Prize from the American Academy of Neurology (2009).

Affiliations and Expertise

Professor of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

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