The Molecular and Cellular Basis of Neurodegenerative Diseases

The Molecular and Cellular Basis of Neurodegenerative Diseases

Underlying Mechanisms

1st Edition - March 29, 2018

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  • Editor: Michael S. Wolfe
  • eBook ISBN: 9780128113059
  • Hardcover ISBN: 9780128113042

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The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field.

Key Features

  • Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features
  • Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration
  • Details features, advantages and limitations of animal models, as well as prospects for therapeutic development
  • Authored by internationally recognized leaders in the field
  • Includes illustrations that help clarify and consolidate complex concepts


Graduate students in biological and biomedical sciences, neuroscientists, neurobiologists, neuropathologists, biological psychiatrists, post-doctoral fellows, researchers

Table of Contents

  • 1. General Overview
      Michael S. Wolfe
    2. Prion Diseases
      Robert C.C. Mercer, Alex J. McDonald, Erin Bove-Fenderson, Cheng Fang, Bei Wu and David Harris
    3. Alzheimer’s disease: towards a quantitative biological approach in describing its natural history and underlying mechanisms
      Colin Masters
    4. Neurodegeneration and the ordered assembly of Tau
      Michael Goedert
    5. ALS and Other TDP43 Proteinopathies
      Christopher Shaw and Jorge Gomez-Deza
    6. Parkinson’s Disease and Other Synucleinopathies
      Mark R. Cookson
    7. Huntington’s Disease and Other Polyglutamine Disorders
      Albert R. La Spada and Audrey Dickey
    8. Prion-like propagation in Neurodegenerative Diseases
      Patrik Brundin, Veerle Baekelandt and Wouter Peelaerts
    9. Neurodegenerative Diseases as Protein Folding Disorders
      Jack Mathew Webster
    10. Heat shock proteins and protein quality control in Alzheimer's disease
      Fred van Leeuwen and Harm H. Kampinga
    11. Neurodegenerative Diseases and Autophagy
      David C. Rubinsztein
    12. Neurodegenerative Diseases and Axonal Transport
      Larry Goldstein and Utpal Das
    13. Mitochondrial Function and Neurodegenerative Diseases
      Russell Swerdlow
    14. Neurodegenerative Diseases and Non-cell autonomous toxicity
      Azad Bonni
    15. Neurodegenerative Diseases and RNA-mediated toxicity
      Tiffany Todd and Leonard Petrucelli
    16. Neuroinflammation in Age-Related Neurodegenerative Diseases
      Kathryn MacPherson, Maria Elizabeth de Sousa Rodrigues, Amarallys F. Cintron and Malú G. Tansey
    17. Neurodegenerative Diseases and the Aging Brain
      Stephen Kenneth Godin, Jinsoo Seo, and Li-Huei Tsai

Product details

  • No. of pages: 560
  • Language: English
  • Copyright: © Academic Press 2018
  • Published: March 29, 2018
  • Imprint: Academic Press
  • eBook ISBN: 9780128113059
  • Hardcover ISBN: 9780128113042

About the Editor

Michael S. Wolfe

Michael S. Wolfe is the Mathias P. Mertes Professor of Medicinal Chemistry at the University of Kansas. He received his B.S. in chemistry in 1984 from the Philadelphia College of Pharmacy and Science and Ph.D. in medicinal chemistry in 1990 from the University of Kansas. After postdoctoral stints at the University of Kansas (medicinal chemistry) and the NIH (cell biology), he joined the faculty of the University of Tennessee in Memphis in 1994. In 1999, he joined the faculty at Brigham and Women’s Hospital and Harvard Medical School in Boston, becoming Professor of Neurology in 2008. Prof. Wolfe’s work has focused on understanding the molecular basis of Alzheimer’s disease and related disorders, and identifying effective approaches for pharmacological intervention. Awards for his work include the Sato Memorial International Award in bioorganic and medicinal chemistry from the Pharmaceutical Society of Japan (2003), the MetLife Award for Biomedical Research (2008), a Zenith Fellows Award from the Alzheimer’s Association (2008), and the Potamkin Prize from the American Academy of Neurology (2009).

Affiliations and Expertise

Professor of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

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