The Mitochondrion in the Germline and Early Development

The Mitochondrion in the Germline and Early Development

1st Edition - January 17, 2007

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  • Editor: Gerald Schatten
  • eBook ISBN: 9780080471136
  • Hardcover ISBN: 9780123736628

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Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. These volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.

Key Features

  • Includes many descriptive figures
  • Topics covered include the role of mitochondrial function, the use of ARTs to regulate mtDNA disease, nuclear transfer, and more
  • Latest volume in the series that covers 10 reviews from leading authorities in developmental biology


Developmental biologists, cell biologists, genetics researchers, molecular biologists, and plant and animal biologists

Table of Contents

  • Section I. The mitochondrion and gametes

    Chapter 1
    The role of the mitochondrion in sperm function. Is there a place for oxidative phosphorylation or is this a purely glycolytic process?
    Eduardo Ruiz-Pesini, Carmen Díez-Sánchez, Manuel José López-Pérez and José Antonio Enríquez

    Chapter 2
    The role of mitochondrial function in the oocyte and embryo
    Remi Dumollard, Michael Duchen, John Carroll

    Chapter 3
    Mitochondrial DNA in the Oocyte and the developing embryo
    Pascale May-Panloup, Marie-Françoise Chretien, Yves Malthier, Pascal Reynier

    Section II. Transmission

    Chapter 4
    Mitochondrial DNA and the mammalian oocyte
    Eric A. Shoubridge and Timothy Wai

    Chapter 5
    Mitochondrial disease - its impact, aetiology and pathology
    McFarland R, Taylor RW and Turnbull DM

    Chapter 6
    Cybrid models of mtDNA disease and transmission, from cells to mice
    Ian A. Trounce, Carl A. Pinkert

    Section III. The use of ARTs to regulate mtDNA disease.

    Chapter 7
    The use of Micromanipulation Methods as a Tool to Prevention of Transmission of Mutated Mitochondrial DNA
    Helena Fulka, Josef Fulka, Jr.

    Chapter 8
    Difficulties and possible solutions in the Genetic Management of mtDNA disease in the pre-implantation embryo
    Joanna Poulton, Pippa Oakeshott, Stephen H. Kennedy

    Section IV. The effects of invasive ARTs on mtDNA transmission

    Chapter 9
    Impact of assisted reproductive techniques: a mitochondrial perspective from the cytoplasmic transplantion
    Carol Brenner, A. J. Harvey, T. C. Gibson

    Chapter 10
    Nuclear Transfer – preservation of a nuclear genome at the expense of its associated mtDNA genome(s)
    Emma J. Bowles, Keith H. S. Campbell, Justin C. St. John

Product details

  • No. of pages: 344
  • Language: English
  • Copyright: © Academic Press 2007
  • Published: January 17, 2007
  • Imprint: Academic Press
  • eBook ISBN: 9780080471136
  • Hardcover ISBN: 9780123736628

About the Serial Editor

Gerald Schatten

Affiliations and Expertise

University of Pittsburgh School of Medicine, PA, U.S.A.

About the Editor

Justin St. John

Affiliations and Expertise

The Medical School, The University of Birmingham, U.K.

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