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The Mitochondrion in the Germline and Early Development - 1st Edition - ISBN: 9780123736628, 9780080471136

The Mitochondrion in the Germline and Early Development, Volume 77

1st Edition

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Serial Editor: Gerald Schatten
Editor: Justin St. John
Hardcover ISBN: 9780123736628
eBook ISBN: 9780080471136
Imprint: Academic Press
Published Date: 17th January 2007
Page Count: 344
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Table of Contents

Section I. The mitochondrion and gametes

Chapter 1 The role of the mitochondrion in sperm function. Is there a place for oxidative phosphorylation or is this a purely glycolytic process? Eduardo Ruiz-Pesini, Carmen Díez-Sánchez, Manuel José López-Pérez and José Antonio Enríquez

Chapter 2 The role of mitochondrial function in the oocyte and embryo Remi Dumollard, Michael Duchen, John Carroll

Chapter 3 Mitochondrial DNA in the Oocyte and the developing embryo Pascale May-Panloup, Marie-Françoise Chretien, Yves Malthier, Pascal Reynier

Section II. Transmission

Chapter 4 Mitochondrial DNA and the mammalian oocyte Eric A. Shoubridge and Timothy Wai

Chapter 5 Mitochondrial disease - its impact, aetiology and pathology McFarland R, Taylor RW and Turnbull DM

Chapter 6 Cybrid models of mtDNA disease and transmission, from cells to mice Ian A. Trounce, Carl A. Pinkert

Section III. The use of ARTs to regulate mtDNA disease.

Chapter 7 The use of Micromanipulation Methods as a Tool to Prevention of Transmission of Mutated Mitochondrial DNA Helena Fulka, Josef Fulka, Jr.

Chapter 8 Difficulties and possible solutions in the Genetic Management of mtDNA disease in the pre-implantation embryo Joanna Poulton, Pippa Oakeshott, Stephen H. Kennedy

Section IV. The effects of invasive ARTs on mtDNA transmission

Chapter 9 Impact of assisted reproductive techniques: a mitochondrial perspective from the cytoplasmic transplantion
Carol Brenner, A. J. Harvey, T. C. Gibson

Chapter 10 Nuclear Transfer – preservation of a nuclear genome at the expense of its associated mtDNA genome(s) Emma J. Bowles, Keith H. S. Campbell, Justin C. St. John


Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. These volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.

Key Features

  • Includes many descriptive figures
  • Topics covered include the role of mitochondrial function, the use of ARTs to regulate mtDNA disease, nuclear transfer, and more
  • Latest volume in the series that covers 10 reviews from leading authorities in developmental biology


Developmental biologists, cell biologists, genetics researchers, molecular biologists, and plant and animal biologists


No. of pages:
© Academic Press 2007
17th January 2007
Academic Press
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Serial Editor

Gerald Schatten

Affiliations and Expertise

University of Pittsburgh School of Medicine, PA, U.S.A.

About the Editor

Justin St. John

Affiliations and Expertise

The Medical School, The University of Birmingham, U.K.