The Microbiology of Skin, Soft Tissue, Bone and Joint Infections

The Microbiology of Skin, Soft Tissue, Bone and Joint Infections

1st Edition - April 25, 2017

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  • Editors: Kateryna Kon, Mahendra Rai
  • eBook ISBN: 9780128110935
  • Paperback ISBN: 9780128110799

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The Microbiology of Skin, Soft Tissue, Bone and Joint Infections: Volume 2 discusses modern approaches in diagnosis, treatment, and prophylaxis of skin, soft tissue, bone, and joint infections. The volume has been divided into three sections. The first section includes chapters on diagnosis, treatment, and prophylaxis of skin and soft tissue infections. It discusses antimicrobial and surgical treatment of wounds, diabetic foot, and different soft tissue infections. Ten chapters are devoted to cutaneous and musculoskeletal infections in special groups of patients, which have their own specificity, i.e. in pediatric and HIV-infected patients. Together with chapters on commonly present diseases, there are chapters which discuss interesting but not well studied pathologies (natal cleft pilonidal sinus) and pathogens (Malassezia and Shewanella spp.). The second section reviews etiology, pathogenesis, diagnosis and treatment of bone and joint infections, mainly osteomyelitis and prosthetic joint infections. Also, one chapter in this section discusses a newly emerging bacterial pathogen that causes skeletal infections, Kingella kingae. The third section incorporates alternative and new approaches—such as nanotechnology, ultrasound, novel delivery approaches and phyto-derived medicines—to the treatment and prophylaxis of skin, soft tissue, bone, and joint infections.

Key Features

  • Encompasses a broad range of skin, soft tissue, bone, and joint infections, including questions of etiology, pathogenesis, diagnosis, prognosis, treatment, and prophylaxis
  • Written by highly professional and eminent surgeons, microbiologists, and infectious disease specialists
  • Discusses topics using modern insight, providing all necessary scientific information on each aspect
  • Includes scientific understanding and practical guidelines, which make it interesting for both research scientists and practitioners working with skin, soft tissue, bone, and joint infections


University professors, medical practitioners, graduate and postgraduate students, researchers in microbiology and in different medical specialties, pharmacology, and biotechnology; specialists from pharmaceutical and laboratory diagnostic companies

Table of Contents

  • Section I: Skin and Soft Tissue Infections: Diagnosis and Treatment

    Chapter 1: Soft Tissue Infections: Consideration Regarding Different International Guidelines

    • Abstract
    • 1 Introduction
    • 2 Classification
    • 3 Necrotizing Soft Tissue Infections
    • 4 Conclusion

    Chapter 2: Evidence-Informed Approach to Pilonidal Sinus Disease and Related Disorders

    • Abstract
    • 1 Introduction
    • 2 Pathophysiology
    • 3 Theories of Formation
    • 4 Epidemiology and Risk Factors
    • 5 Types of PSD
    • 6 Differential Diagnosis
    • 7 Surgical Treatment
    • 8 Other Treatment Considerations
    • 9 Conclusion

    Chapter 3: The Microbiome of Diabetic Foot Ulcers and the Role of Biofilms

    • Abstract
    • 1 Diabetic Foot Infection
    • 2 Biofilms
    • 3 Summary

    Chapter 4: Cutaneous and Musculoskeletal Complications in Human Immunodeficiency Virus Infection

    • Abstract
    • 1 Introduction
    • 2 Infective Complications
    • 3 Noninfective Complications
    • 4 Immune Reconstitution Inflammatory Syndrome
    • 5 Perspectives for Further Research
    • 6 Conclusion
    • Acknowledgments

    Chapter 5: Diseases Caused by Malassezia Species in Human Beings

    • Abstract
    • 1 Introduction
    • 2 Ecology of Malassezia Yeasts
    • 3 Malassezia-Associated Skin Diseases
    • 4 Systemic and Invasive Infections
    • 5 Conclusion

    Chapter 6: Skin and Soft Tissue Infections Following Marine Injuries

    • Abstract
    • 1 Introduction
    • 2 Epidemiology
    • 3 Control and Prevention of Aquatic Infections
    • 4 Conclusion and Future Perspectives

    Chapter 7: Gordonia and Related Genera as Opportunistic Human Pathogens Causing Infections of Skin, Soft Tissues, and Bones

    • Abstract
    • 1 Introduction
    • 2 Gordonia
    • 3 Nocardia
    • 4 Rhodococcus
    • 5 Conclusions

    Section II: Bone and Joint Infections: Diagnosis and Treatment

    Chapter 8: The Molecular Mechanics of Inflammatory Bone and Joint Disease Caused by Microbial Infection

    • Abstract
    • 1 Introduction
    • 2 Mechanism of Infection
    • 3 Site of Infection
    • 4 Current Treatments for Bone Infection
    • 5 Bacterial Interaction
    • 6 Conclusion

    Chapter 9: Microbiological Diagnosis of Prosthetic Joint Infections

    • Abstract
    • 1 Introduction
    • 2 Culture-Based Diagnosis of PJI
    • 3 Molecular Biology-Based Diagnosis of PJI
    • 4 Conclusions

    Chapter 10: Laboratory Detection of the Emergent Pathogen Kingella kingae in Children With Septic Arthritis

    • Abstract
    • 1 Introduction
    • 2 The Organism
    • 3 Pathogenesis of Invasive K. kingae Disease
    • 4 Clinical Presentation of K. kingae Septic Arthritis
    • 5 Culture Detection of K. kingae
    • 6 Detection of K. kingae by NAAAs
    • 7 Conclusions

    Section III: Alternative and Novel Approaches to the Diagnosis and Treatment of Skin, Soft Tissue, Bone, and Joint Infections

    Chapter 11: Nanotechnology for the Treatment of Fungal Infections on Human Skin

    • Abstract
    • 1 Introduction
    • 2 Different Types of Skin Infections
    • 3 Diagnosis of Fungal Skin Infections
    • 4 Treatment
    • 5 The Need of Nanotechnology in Skin Infections
    • 6 Antifungal Nanogel and Formulations
    • 7 Nanotoxicity to Skin
    • 8 Conclusion
    • Acknowledgments

    Chapter 12: Alternative Antimicrobials from Natural Products Against Dermatological Infections

    • Abstract
    • 1 Introduction
    • 2 Common Dermatological Infections from Microorganisms
    • 3 The Shortcomings of Conventional Antimicrobials
    • 4 Natural Products as Alternatives to Conventional Antimicrobials
    • 5 Ethnobotanical Studies
    • 6 Plant-Derived Antimicrobials
    • 7 In Vitro Studies of Plant Species and Their Metabolites Against DIs
    • 8 Fruits and Vegetables as a Source of Antimicrobials
    • 9 Essential Oils
    • 10 Antimicrobials of Animal Origin
    • 11 Antimicrobials of Marine Origin
    • 12 Antibiotics of Bacterial Origin
    • 13 Controlled Clinical Trials of Herbal Medicines Against Dermatological Infections
    • 14 Discussion
    • 15 Conclusion

    Chapter 13: Medicinal Plants Versus Skin Disorders: A Survey From Ancient to Modern Herbalism

    • Abstract
    • 1 Introduction
    • 2 Medicinal Plants Versus Skin Disorders
    • 3 Microbial Infections of Skin
    • 4 Conclusion and Perspectives
    • Acknowledgment

    Chapter 14: Natural Products as Source of New Antimicrobial Compounds for Skin Infections

    • Abstract
    • 1 Introduction
    • 2 Clinical and Investigational Approach to Skin Bacterial Infections
    • 3 Natural Remedies in Skin Infection Diseases
    • 4 Alkaloids
    • 5 Phenolic Compounds (Lignans, Xanthones)
    • 6 Diterpenes
    • 7 FAs and Lipids
    • 8 Carbohydrates
    • 9 Conclusion

    Chapter 15: Role of Medicinal Plants and Bioactive Compounds Against Skin Disease–Causing Microbes, With Special Emphasis on Their Mechanisms of Action

    • Abstract
    • 1 Introduction
    • 2 Types of Skin Infections
    • 3 Causes of Antibiotic Resistance
    • 4 Indigenous Knowledge
    • 5 Scientific Knowledge Applied to Use of Medicinal Plants
    • 6 Plants as a Rich Source of Bioactive Compounds (Secondary Metabolites)
    • 7 Combined Preparations Used to Treat Skin Infections
    • 8 Conclusions and Future Perspectives

    Chapter 16: Antimicrobial Strategies in Novel Drug Delivery Systems: Applications in the Treatment of Skin and Soft Tissue Infections

    • Abstract
    • 1 Introduction
    • 2 Drug Delivery and the Skin
    • 3 Application Models
    • 4 Skin Infections, Natural Products, and Nanotechnology
    • 5 Conclusions and Perspectives
    • Acknowledgments

    Chapter 17: Medical, Surgical Therapy, and Alternative Treatment of Infected Vascular Grafts

    • Abstract
    • 1 Introduction
    • 2 Epidemiology and Pathophysiology
    • 3 Clinic
    • 4 Classification
    • 5 Instrumental Studies
    • 6 Medical Therapy
    • 7 Surgical and Alternative Treatment
    • 8 Endovascular Treatment
    • 9 Conclusions

    Chapter 18: Dermoscopy Findings in Infectious and Parasitic Diseases

    • Abstract
    • 1 Introduction
    • 2 Viral Infections
    • 3 Fungal Infections
    • 4 Infestations by Parasites
    • 5 Conclusions and Future Prospects

Product details

  • No. of pages: 338
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: April 25, 2017
  • Imprint: Academic Press
  • eBook ISBN: 9780128110935
  • Paperback ISBN: 9780128110799

About the Editors

Kateryna Kon

Kateryna Kon
Dr. Kateryna Kon, MD, PhD, currently works at the Department of Microbiology, Virology and Immunology at Kharkiv National Medical University, Kharkiv, Ukraine as an Associate Professor. Dr. Kon received the Best Young Scientist of Kharkiv Award in 2007. She has ten years of teaching and fifteen years of research experience. She is an editorial board member of six international peer-reviewed journals.

Dr. Kon's scientific contributions include more than 100 publications, 6 books and 18 scientific articles. The main focus of Dr. Kon’s research is antibiotic resistance in bacteria, coping with microbial resistance by plant essential oils and nanoparticles, microbiology of surgical and gynaecological infections, application of different statistical methods to analysis of biomedical data.

Affiliations and Expertise

Associate Professor, Department of Microbiology, Virology and Immunology, Kharkiv National Medical University, Kharkiv, Ukraine

Mahendra Rai

Mahendra Rai
Professor Mahendra Rai UGC-BSR Fellow is presently Visiting Professor in Department of Microbiology, Nicolaus Copernicus University, Torun, Poland. Formerly he was Headead at the Department of Biotechnology, Sant Gadge Baba Amravati University at Amravati, Maharashtra, India. He was Visiting Scientist at different Universities like University of Geneva, Switzerland, Debrecen University, University of Campinas, Brazil, Nicolaus Copernicus University, Poland. His area of expertise includes microbial biotechnology and nanobiotechnology. His present research interests are application of nanobiotechnology in medicine and agriculture, in particular, the use of metallic nanoparticles as a new generation of antimicrobials. He has published more than 450 research papers in India and abroad. In addition, he has edited/authored more than 65 books.

Affiliations and Expertise

Professor and Head, Department of Biotechnology, Amravati University, Amravati, Maharashtra, India

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