The Makings of a Clinical Protocol

The Makings of a Clinical Protocol

A Journey from Pure to Applied Biomedical Research and Beyond

1st Edition - January 1, 2023

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  • Editor: Bruce Kowiatek
  • Paperback ISBN: 9780323957496

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The Makings of a Clinical Protocol: A Journey from Pure to Applied Biomedical Research and Beyond presents step-by-step how to develop a clinical protocol to both researchers and students involved in biomedical research. It discusses several protocols as case studies to illustrate the point that pure and applied research are interdependent upon and mutually beneficial to each other. The cases examined cover diverse topics of biomedical field and can be easily adapted to fulfill readers’ specific needs. It is a valuable resource for researchers, students, and anyone who is interested in learning more about clinical protocol.

Key Features

  • Presents a guide to turning pure scientific research into a practical applied research protocol with positive results
  • Discusses the most recent and successful cancer protocols and how it came to be with the possibility to reproduce them to different fields
  • Demonstrates through case studies the step-by-step to develop an efficient clinical protocol by showing what have and have not worked in those examples


Cancer and basic science researchers; practicing oncologists; Graduate students and faculty members in life sciences courses

Table of Contents

  • 1. Rooted tRNAomes and evolution of the genetic code
    2. Aminoacyl-tRNA synthetase evolution and sectoring of the genetic code
    3. Evolution of life on earth: Polymers → Minihelices → Cloverleaf tRNA, Type I and Type II tRNAs aaRS
    4. Type II tRNAs and evolution of translation systems and the genetic code
    5. An additional, complementary mechanism of action for folic acid in the treatment of megaloblastic anemia
    6. Non-enzymatic methylation of cytosine in RNA by S-adenosylmethionine and implications for the evolution of translation
    7. Evolution of life on Earth: tRNA, aminoacyl-tRNA synthetases and the genetic code
    8. The 3 Minihelix tRNA Evolution Theorem
    9. Methylating agents as adjunct therapy to chemotherapeutic alkylating medications for improved outcomes in chronic lymphocytic leukemia: A case study
    10. Chaos, Order and Systematics in Evolution of the Genetic Code
    11. Evolution of the genetic code

Product details

  • No. of pages: 350
  • Language: English
  • Copyright: © Academic Press 2023
  • Published: January 1, 2023
  • Imprint: Academic Press
  • Paperback ISBN: 9780323957496

About the Editor

Bruce Kowiatek

Dr. Bruce K. Kowiatek PhD earned his Bachelor’s in English Writing from the University of Pittsburgh in 1998, and his Doctorate in Pharmacy and Master’s in Business Administration from Shenandoah University in 2002. In addition to researching and investigating the origins of life for over 20 years, he has also published books and papers on a variety of topics, worked as a clinical pharmacist, and is currently full-time Allied Health Faculty at Blue Ridge Community and Technical College in Martinsburg,

Affiliations and Expertise

Full-time Allied Health Faculty, Blue Ridge Community and Technical College in Martinsburg, WV, USA

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