The Liver - 1st Edition - ISBN: 9781483228273, 9781483271767

The Liver

1st Edition

Morphology, Biochemistry, Physiology

Editors: Ch. Rouiller
eBook ISBN: 9781483271767
Imprint: Academic Press
Published Date: 1st January 1964
Page Count: 688
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The Liver: Morphology, Biochemistry, Physiology, Volume II provides a comprehensive information on the liver under normal and pathological conditions, as revealed by physiological and morphological studies. This book discusses the excretory function of the liver cell, the physiology of the Kupffer cells, and the link of the liver with endocrine organs, blood, and vitamins. Organized into 15 chapters, this book begins with an overview of the formation and excretion of bile acids. This text then examines the various aspects associated with liver regeneration. Other chapters describe the liver function tests and the methods of experimental surgery. This book discusses as well the pathological changes responsible for the bleeding tendency of patients with liver disease. The final chapter deals with the general and experimental pathology of the organ and its regeneration, as well as with the problem of necrotropic substances. This book is a valuable resource for biochemists, pharmacologists, morphologists, and clinicians.

Table of Contents



Contents of Volume I (Chapters 1-11)

12. Excretory Function of the Liver

I. Introduction

II. Bile Formation

III. Bile Acids

IV. Bile Pigments

V. Sulfobromophthalein Sodium


13. Functions of the Kupffer Cells

I. Historical Survey

II. Functions of Kupffer Cells

III. Factors That Modify Functions of Kupffer Cells


14. Regeneration of the Liver

I. Introduction

II. Regeneration after Partial Hepatectomy

III. Regeneration after Acute Doses of Necrotizing Agents

IV. Regeneration after Bile Duct Obstruction

V. Regeneration after Chronic Dietary Injury

VI. Conclusion



15. The Liver and Steroid Hormone Metabolism

I. Sites of Origin and Nature of Primary Steroid Hormones

II. Factors Modifying Plasma Hormone Levels

III. Turnover Rates

IV. Excretory Pathways

V. Metabolic Patterns of Neutral Steroid Hormones

VI. Metabolic Patterns of Phenolic Steroid Hormones

VII. Conjugation of Steroid Hormones

VIII. Effects of Liver Disease

IX. Other Clinical Disorders Affecting Liver Function

X. Steroid Metabolism in the Fetus and Infant

XI. Role of the Liver in Steroid Pharmacology

XII. Summary


16. The Liver and Vitamins

I. Introduction

II. Vitamin A

III. Vitamin D

IV. Vitamin E

V. Vitamin K

VI. Vitamin B1

VII. Vitamin B2

VIII. Vitamin B6

IX. Vitamin B12

X. Folic Acid

XI. Biotin

XII. Nicotinic Acid

XIII. Pantothenic Acid

XIV. Vitamin C


17. Liver and Blood Coagulation

I. Introduction

II. Mechanism of Blood Coagulation

III. Coagulation Factors or Procoagulants

IV. Liver Diseases and Procoagulants

V. Site of Procoagulant Synthesis in the Organism

VI. The Role of Vitamin K

VII. Other Mechanisms Affecting Blood Coagulation in Liver Disease, Unrelated to Deficient Procoagulant Synthesis


18. Liver Function Tests

I. Introduction

II. The Purifying Activity of the Reticuloendothelial System

III. The Purifying Activity of the Hepatic Parenchyma

IV. Uptake of Vitamin B12 by the Liver

V. Metabolism of Bilirubin

VI. Serum Albumin and the Reactions of Protein Imbalance of the Blood

VII. Enzymatic Activities of Fragments Obtained by Puncture Biopsy


19. Methods and Techniques for Measurement of Hepatic Physiology and Metabolism

I. Introduction

II. Hepatectomy—the Study of the Liverless Animal

III. Hepatic Perfusion Techniques—the Bridge between in Vitro and in Vivo Studies

IV. Methods for Catheterizing the Major Hepatic Vessels—a Preparation for the Study of Hepatic Physiology and Metabolism in Vivo

V. Hepatic Blood Flow Methods

VI. Hepatic Vascular Procedures


20. Death of Liver Tissue A Review of Cell Death, Necrosis, and Autolysis

I. Terminology: "Cellular Death," "Necrosis," "Autolysis"

II. Methods for the Study of Cell Death in Liver Tissue

III. Studies on Liver Implants

IV. Studies on Liver Tissues in Vitro and Post-Mortem

V. Death of a Liver Cell: A Tentative Sequence of Events


21. Experimental Dietetic Injury of the Liver

I. Introduction

II. Etiological Factors

III. Pathogenesis

IV. Relation of Experimental Dietary Liver Disease to Primary Tumors of the Liver


22. Experimental Toxic Injury of the Liver

I. Introduction

II. General Considerations

III. The Production of Hepatic Changes by Toxins

IV. Modifying Factors of Toxic Reaction

V. Pathogenesis of Experimental Toxic Injury


23. Experimental Cirrhosis

I. Introduction

II. Morphologic Types of Cirrhosis

III. General Concept of Pathogenesis of Cirrhosis ( Architecture )

IV. Fibrogenesis and Collagenosis

V. Pathogenesis of Regeneration Nodules

VI. Special Features

VII. Contributions from the Studies of Experimental Cirrhosis to the Problem in Man

VIII. Congenital Cirrhosis in Experimental Animals

IX. Obstructive Cirrhosis

X. Toxic Agents

XI. Experimental Cirrhosis Following Infections

XII. Cirrhogenic Agents of a Metabolic Nature

XIII. Conclusion


24. Carcinoma of the Liver in Man

I. Classification of Carcinomata of the Liver

II. Morphology of Hepatocellular Carcinoma

III. Transformation of Hepatic Muralium into Ductal Structures

IV. Spread of Hepatoma and Cholangioma

V. Metastatic Carcinoma to the Liver

VI. Relation of Hepatoma to Cirrhosis

VII. Frequency of Primary Liver Cancer


25. Liver and Viruses: Experimental Studies

I. Introduction

II. Review of Representative Studies

III. Equine Abortion Virus (EAV)


26. The Necrotropic Liver-Protective Substances

I. Degeneration and Necrosis of the Liver Cell as a Scale for Measuring the Necrotropic Effect

II. Testing of Liver-Protective Substances

III. The Necrotropic Substances, Their Classification and Grouping

IV. General Considerations of the Mode of Action of Necrotropic Substances


Author Index

Subject Index


No. of pages:
© Academic Press 1964
Academic Press
eBook ISBN:

About the Editor

Ch. Rouiller

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