The Liver

The Liver

Morphology, Biochemistry, Physiology

1st Edition - January 1, 1964

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  • Editor: Ch. Rouiller
  • eBook ISBN: 9781483271767

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The Liver: Morphology, Biochemistry, Physiology, Volume II provides a comprehensive information on the liver under normal and pathological conditions, as revealed by physiological and morphological studies. This book discusses the excretory function of the liver cell, the physiology of the Kupffer cells, and the link of the liver with endocrine organs, blood, and vitamins. Organized into 15 chapters, this book begins with an overview of the formation and excretion of bile acids. This text then examines the various aspects associated with liver regeneration. Other chapters describe the liver function tests and the methods of experimental surgery. This book discusses as well the pathological changes responsible for the bleeding tendency of patients with liver disease. The final chapter deals with the general and experimental pathology of the organ and its regeneration, as well as with the problem of necrotropic substances. This book is a valuable resource for biochemists, pharmacologists, morphologists, and clinicians.

Table of Contents

  • Contributors


    Contents of Volume I (Chapters 1-11)

    12. Excretory Function of the Liver

    I. Introduction

    II. Bile Formation

    III. Bile Acids

    IV. Bile Pigments

    V. Sulfobromophthalein Sodium


    13. Functions of the Kupffer Cells

    I. Historical Survey

    II. Functions of Kupffer Cells

    III. Factors That Modify Functions of Kupffer Cells


    14. Regeneration of the Liver

    I. Introduction

    II. Regeneration after Partial Hepatectomy

    III. Regeneration after Acute Doses of Necrotizing Agents

    IV. Regeneration after Bile Duct Obstruction

    V. Regeneration after Chronic Dietary Injury

    VI. Conclusion



    15. The Liver and Steroid Hormone Metabolism

    I. Sites of Origin and Nature of Primary Steroid Hormones

    II. Factors Modifying Plasma Hormone Levels

    III. Turnover Rates

    IV. Excretory Pathways

    V. Metabolic Patterns of Neutral Steroid Hormones

    VI. Metabolic Patterns of Phenolic Steroid Hormones

    VII. Conjugation of Steroid Hormones

    VIII. Effects of Liver Disease

    IX. Other Clinical Disorders Affecting Liver Function

    X. Steroid Metabolism in the Fetus and Infant

    XI. Role of the Liver in Steroid Pharmacology

    XII. Summary


    16. The Liver and Vitamins

    I. Introduction

    II. Vitamin A

    III. Vitamin D

    IV. Vitamin E

    V. Vitamin K

    VI. Vitamin B1

    VII. Vitamin B2

    VIII. Vitamin B6

    IX. Vitamin B12

    X. Folic Acid

    XI. Biotin

    XII. Nicotinic Acid

    XIII. Pantothenic Acid

    XIV. Vitamin C


    17. Liver and Blood Coagulation

    I. Introduction

    II. Mechanism of Blood Coagulation

    III. Coagulation Factors or Procoagulants

    IV. Liver Diseases and Procoagulants

    V. Site of Procoagulant Synthesis in the Organism

    VI. The Role of Vitamin K

    VII. Other Mechanisms Affecting Blood Coagulation in Liver Disease, Unrelated to Deficient Procoagulant Synthesis


    18. Liver Function Tests

    I. Introduction

    II. The Purifying Activity of the Reticuloendothelial System

    III. The Purifying Activity of the Hepatic Parenchyma

    IV. Uptake of Vitamin B12 by the Liver

    V. Metabolism of Bilirubin

    VI. Serum Albumin and the Reactions of Protein Imbalance of the Blood

    VII. Enzymatic Activities of Fragments Obtained by Puncture Biopsy


    19. Methods and Techniques for Measurement of Hepatic Physiology and Metabolism

    I. Introduction

    II. Hepatectomy—the Study of the Liverless Animal

    III. Hepatic Perfusion Techniques—the Bridge between in Vitro and in Vivo Studies

    IV. Methods for Catheterizing the Major Hepatic Vessels—a Preparation for the Study of Hepatic Physiology and Metabolism in Vivo

    V. Hepatic Blood Flow Methods

    VI. Hepatic Vascular Procedures


    20. Death of Liver Tissue A Review of Cell Death, Necrosis, and Autolysis

    I. Terminology: "Cellular Death," "Necrosis," "Autolysis"

    II. Methods for the Study of Cell Death in Liver Tissue

    III. Studies on Liver Implants

    IV. Studies on Liver Tissues in Vitro and Post-Mortem

    V. Death of a Liver Cell: A Tentative Sequence of Events


    21. Experimental Dietetic Injury of the Liver

    I. Introduction

    II. Etiological Factors

    III. Pathogenesis

    IV. Relation of Experimental Dietary Liver Disease to Primary Tumors of the Liver


    22. Experimental Toxic Injury of the Liver

    I. Introduction

    II. General Considerations

    III. The Production of Hepatic Changes by Toxins

    IV. Modifying Factors of Toxic Reaction

    V. Pathogenesis of Experimental Toxic Injury


    23. Experimental Cirrhosis

    I. Introduction

    II. Morphologic Types of Cirrhosis

    III. General Concept of Pathogenesis of Cirrhosis ( Architecture )

    IV. Fibrogenesis and Collagenosis

    V. Pathogenesis of Regeneration Nodules

    VI. Special Features

    VII. Contributions from the Studies of Experimental Cirrhosis to the Problem in Man

    VIII. Congenital Cirrhosis in Experimental Animals

    IX. Obstructive Cirrhosis

    X. Toxic Agents

    XI. Experimental Cirrhosis Following Infections

    XII. Cirrhogenic Agents of a Metabolic Nature

    XIII. Conclusion


    24. Carcinoma of the Liver in Man

    I. Classification of Carcinomata of the Liver

    II. Morphology of Hepatocellular Carcinoma

    III. Transformation of Hepatic Muralium into Ductal Structures

    IV. Spread of Hepatoma and Cholangioma

    V. Metastatic Carcinoma to the Liver

    VI. Relation of Hepatoma to Cirrhosis

    VII. Frequency of Primary Liver Cancer


    25. Liver and Viruses: Experimental Studies

    I. Introduction

    II. Review of Representative Studies

    III. Equine Abortion Virus (EAV)


    26. The Necrotropic Liver-Protective Substances

    I. Degeneration and Necrosis of the Liver Cell as a Scale for Measuring the Necrotropic Effect

    II. Testing of Liver-Protective Substances

    III. The Necrotropic Substances, Their Classification and Grouping

    IV. General Considerations of the Mode of Action of Necrotropic Substances


    Author Index

    Subject Index

Product details

  • No. of pages: 688
  • Language: English
  • Copyright: © Academic Press 1964
  • Published: January 1, 1964
  • Imprint: Academic Press
  • eBook ISBN: 9781483271767

About the Editor

Ch. Rouiller

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