The Liver - 1st Edition - ISBN: 9780128039519, 9780128039786

The Liver

1st Edition

Oxidative Stress and Dietary Antioxidants

Editors: Vinood Patel Rajkumar Rajendram
eBook ISBN: 9780128039786
Paperback ISBN: 9780128039519
Imprint: Academic Press
Published Date: 4th January 2018
Page Count: 368
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The Liver: Oxidative Stress and Dietary Antioxidants takes a novel approach to the science of oxidative stress in liver disease by recognizing that diseases are multifactorial and oxidative stress is a single component. It highlights oxidative stress in relation to other processes, such as apoptosis, cell signaling and receptor mediated responses, and includes the therapeutic usage of natural antioxidants in the diet and food matrix, along with coverage of pharmacological and natural agents designed to counteract oxidative stress. Written for research scientists, gastroenterologists, food scientists, hepatologists and physicians, this trans-disciplinary guide will help advance medical sciences and enable new preventative and treatment strategies.

Key Features

  • Provides a framework for in-depth analysis of the basic processes of oxidative stress, from molecular biology, to whole organs in relation to the liver
  • Bridges the trans-disciplinary divide between the basic science and mechanisms of liver disease and oxidative stress to advance medical sciences and enable preventative and treatment strategies
  • Contains contributions from leading national and international experts, including those from world renowned institutions


Research scientists, gastroenterologists, nutritionists and physicians

Table of Contents

Oxidative Stress and the Liver
1. Oxidative stress in hepatitis C infection 
Birke Bartosch
2. Peroxidases and oxidative stress in fatty livers 
Lixin Zhu
3. Alterations in nucleocytoplasmic localization of the methionine cycle induced by oxidative stress during liver disease  
Maria Angeles Pajares
4. Oxidative stress in iron toxicity of the liver
Kosha Mehta
5. Cardiac glycosides and oxidative stress in liver cancer
Rengul Cetin-Atalay
6. Acetaldehyde effects on cellular redox state. 
Luis Enrique Gomez-Quiroz
7. The role of glyoxalase-I in oxidant stress of liver damage
Marcus Hollenbach
8. Antioxidants 1 Reactive oxygen and nitrogen species and liver ischemia-reperfusion injury an overview
Fabienne T.E. Alban, Rowan F. van Golen, Daniel Gyamfi and Michal Heger

Antioxidants and the Liver
9. Antioxidants 2 Reactive oxygen and nitrogen species and liver ischemia-reperfusion injury: role of arginine and glutamine 
Fabienne T.E. Alban, Rowan F. van Golen, Daniel Gyamfi and Michal Heger
10. Antioxidants 2 Reactive oxygen and nitrogen species and liver ischemia-reperfusion injury: role of lipoic acid
Fabienne T.E. Alban, Rowan F. van Golen, Daniel Gyamfi and Michal Heger
11. Oxidative stress as crucial factor in liver disease: Potential Therapeutic effect of Antioxidants 
H.A. Hassan
12. L-NAME as a synthetic antioxidant in liver injury 
Adnan Ayhanci, Sila Appak and Mustafa Cengiz
13. Vitamin C, oxidative stress and liver protection 
Rocio IR Macias
14. Lycopene, liver protection and oxidative stress 
Kazim Sahin
15. Vitamin E protection against hyperthyroidism-induced liver oxidative stress
Paola Venditti
16. Citric acid an antioxidant in liver  
O. M. E. Abdel-salam
17. Resveratrol and protection in hepatic steatosis: antioxidant effects 
Maria Puy Portillo
18. Astaxanthin, a marine carotenoid against hepatic oxidative stress: A systematic review. 
C.V. Anuradha
19. Effects of melatonin as an antioxidant in liver 
Vijay K. Bharti
20. Antioxidant role of the Mayan fruit canistel (Pouteria campechiana) in liver protection
T. Sivasudha
21. Endogenous mitochondrial aldehyde dehydrogenase-2 as an antioxidant in liver
Yanfeng Wang
22. Comparing antioxidants in liver disease: L-carnitine, N-acetylcysteine and genistein 
Kaan Demiroren
23. Coenzyme Q10, liver protection and oxidative stress 
Farnaz Farsi, Pezhman Alavinejad Sr. and Nava Morshedzadeh
24. Carnosine as a putative antioxidant in usage against liver disease
S. Dogru-Abbasoglu
25. Dioscin as a natural saponin and protection in oxidative stress in hepatic fibrosis
J. Peng
26. Gallic acid as a putative antioxidant in usage against liver disease
Jesus Morlett-Chavez
27. Oleuropein as an antioxidant and liver protection
Seung Kew Yoon
28. Garlic and Liver Diseases 
George L. Tipoe, Jia Xiao, Liangliang Zou, Rui Zhang and Hao Gao


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About the Editor

Vinood Patel

Dr Vinood B. Patel is a Senior Lecturer in Clinical Biochemistry at the University of Westminster and honorary fellow at King’s College London. He presently directs studies on metabolic pathways involved in liver disease, particularly related to mitochondrial energy regulation and cell death.

Affiliations and Expertise

Professor, University Westminster, UK

Rajkumar Rajendram

Dr Rajkumar Rajendram is a clinician scientist who has a focus is on anaesthesia, intensive care and peri-operative medicine. Dr Rajendram graduated in 2001 with a distinction from Guy’s, King’s and St. Thomas Medical School, in London. As an undergraduate he was awarded several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram began his post-graduate medical training in general medicine and intensive care in Oxford. He attained membership of the Royal College of Physicians (MRCP) in 2004 and completed specialist training in acute and general medicine in Oxford in 2010. Dr Rajendram also trained in anaesthesia and intensive care in London and became a fellow of the Royal College of Anaesthetists (FRCA) in 2009. He has completed advanced training in regional anaesthesia and intensive care. He became a fellow of the Faculty of Intensive Care Medicine (FFICM) in 2013 and obtained the European diploma of intensive care medicine (EDIC) in 2014.

Dr Rajendram returned to Oxford as a Consultant in Acute General Medicine at the John Radcliffe Hospital, Oxford before moving to the Royal Free London Hospitals as a Consultant in Intensive Care, Anaesthesia and Peri-operative Medicine. He is currently a Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.

Dr Rajendram recognises that nutritional support is a fundamental aspect of medical care. As a clinician scientist he has therefore devoted significant time and effort into nutritional science research and education. He is a visiting lecturer in the Nutritional Sciences Research Division of King’s College London and has published over 100 textbook chapters, review articles, peer-reviewed papers and abstracts.

Affiliations and Expertise

Locum Consultant, Department of Anaesthesia and Intensive Care, Stoke Mandeville Hospital, Aylesbury, Buckinghamshire; Consultant in Internal and Perioperative Medicine, King Abdulaziz Medical City, Ministry of National Guard Hospital Affairs, Riyadh Saudi Arabia; Diabetes and Nutritional Sciences Research Division, School of Medicine, King’s College London, UK

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