The Lectins

The Lectins

Properties, Functions, and Applications in Biology and Medicine

1st Edition - July 1, 1986

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  • Editor: Irvin Liener
  • eBook ISBN: 9780323144445

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Description

The Lectins: Properties, Functions, and Applications in Biology and Medicine is a 10-chapter text that deals with the advances in research studies on the properties, functions, and applications of lectins in biology and medicine. The first two chapters consider the historical development, physicochemical properties, isolation, and remarkable specificity toward sugars of lectins. These topics are followed by a discussion on the molecular aspects of protein evolution, with a particular emphasis on lectins, which provide an excellent example of a family of homologous proteins. The following chapters explore the diverse biological activities of lectins and how these properties are utilized for the isolation and characterization of carbohydrate-containing compounds in solution and on cells. A chapter focuses on the functions of lectins in their natural milieu. This text further covers the importance of lectins in nonplant systems as exemplified by lectins that occur in vertebrates, slime molds, and bacteria. The last chapter highlights the nutritional significance of the occurrence of lectins in plant foods such as legumes. This book is an ideal source for organic chemists, protein researchers, and workers in the fields of biology and medicine.

Table of Contents


  • Contributors

    Preface

    1 Historical Background

    I. The Early or Classical Period (1888-1918)

    II. The Intermediate Period (1919-1934)

    III. The Recognition of Specific Lectin Interactions (1935-1964)

    IV. The Modern Period

    V. The Early Terminology of Lectins

    VI. Early Reviews and Books on Lectins

    References

    2 Isolation, Physicochemical Characterization, and Carbohydrate-Binding Specificity of Lectins

    I. Introduction and General Comments

    II. Mannose/Glucose-Binding Lectins

    III. N-Acetylglucosamine-Binding Lectins

    IV. N-Acetylgalactosamine/Galactose-Binding Lectins

    V. Fucose-Binding Lectins

    VI. Sialic Acid-Binding Lectins

    References

    Appendix: Physical Characteristics of Lectins

    3 Legume Lectins: A Large Family of Homologous Proteins

    I. Common Structural Properties

    II. Chemotaxonomy

    III. Variability of Lectins in Single Plants

    IV. Complete Sequences

    V. Conclusion

    References

    4 Biological Properties of Lectins

    I. Agglutination

    II. Mitogenic Stimulation of Lymphocytes

    III. Induction of Suppressor Cells

    IV. Lectin-Dependent Cytotoxicity of Lymphocytes and Macrophages

    V. Lectin-Mediated Phagocytosis of Target Cells

    VI. Insulinomimetic Activity

    VII. Lectin Toxicity

    References

    5 Applications of Lectins

    I. Isolation and Structural Studies of Glycoconjugates

    II. Studies of Cellular and Subcellular Membranes

    III. Cell Separation

    IV. Identification of Microorganisms

    V. Lectin-Resistant Cells

    VI. Lectins as Drug Carriers

    VII. Clinical Uses

    References

    6 Distribution and Function of Plant Lectins

    I. Introduction

    II. Distribution and Subcellular Localization of Lectins in Plants

    III. Proposed Roles

    IV. Endogenous Lectin Receptors

    V. Regulation of Lectin Synthesis and Activity

    VI. Concluding Remarks

    VII. Addendum

    References

    7 Vertebrate Lectins: Properties and Functions

    I. Soluble Tissue Lectins

    II. Membrane Lectins

    III. Other Vertebrate Lectins

    IV. Conclusion

    References

    8 Lectins in Cellular Slime Molds

    I. Developmental Regulation of Lectins in Slime Molds

    II. Purification and Properties of Slime Mold Lectins

    III. Cellular and Tissue Localization of Lectins

    IV. Glycoconjugate Ligands

    V. Role in Cell Adhesion

    VI. Summary

    References

    9 Bacterial Lectins

    I. Introduction

    II. Surface Lectins of Enterobacteriaceae Specific for Mannose

    III. Surface Lectins of Escherichia coli Specific for Galactosyl α(1 → 4)Galactose (Type P Fimbriae)

    IV. Lectins of Vibrio cholerae Specific for L-Fucose

    V. Fimbrial Lectins of Oral Actinomyces Specific for Galactose and N-Acetylgalactosamine (Type 2 Fimbriae)

    VI. Lectins of Myxobacteria Specific for Galactose Derivatives

    VII. Lectins of Mycoplasma Specific for N-Acetylneuraminyl Galactose

    VIII. Lectins of Pseudomonas aeruginosa Specific for Mannose, Galactose, and L-Fucose/Mannose

    IX. Concluding Remarks

    References

    10 Nutritional Significance of Lectins in the Diet

    I. Introduction

    II. Nutritional Significance of Lectins in Various Plants

    III. Mode of Action

    IV. Significance in the Human Diet

    References

    Index

Product details

  • No. of pages: 618
  • Language: English
  • Copyright: © Academic Press 1986
  • Published: July 1, 1986
  • Imprint: Academic Press
  • eBook ISBN: 9780323144445

About the Editor

Irvin Liener

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  • MathieuLemaire Tue Jul 10 2018

    great book!

    If you want to know about lectins, it covers it all.