The Lancet Handbook of Essential Concepts in Clinical Research

1st Edition

Editors:

  • David Grimes
  • Kenneth Schulz
    • Print ISBN 9780080448664

    Key Features

    • Enables clinicians to read the medical literature more critically
    • Chapters cover: descriptive studies, cohort studies, case control studies, bias, and screening tests
    • Five chapters dedicated to randomized controlled trials

    Table of Contents

    An overview of clinical research: the lay of the land.
    Descriptive studies: what they can and cannot do.
    Bias and causal associations in observational research.
    Cohort studies: marching towards outcome.
    Case-control studies: research in reverse.
    Generation of allocation sequences in randomized trials: chance, not choice.
    Allocation concealment in randomized trials: defending against deciphering.
    Sample size slippages in randomized trials: exclusions and the lost and wayward.
    Blinding in randomized trials: hiding who got what.
    Uses and abuses of screening tests.
    Unequal group sizes in randomized trials: guarding against guessing.
    Sample size calculations in randomized trials: mandatory and mystical.
    Compared to what? Finding controls for case-control studies.
    Refining clinical diagnosis with likelihood ratios.
    Multiplicity in randomized trials I: endpoints and treatments.
    Multiplicity in randomized trials II: subgroup and interim analyses.

    Details

    No. of pages:
    242
    Language:
    English
    Copyright:
    © 2006
    Published:
    Imprint:
    The Lancet
    Print ISBN:
    9780080448664