The Laboratory Rat

The Laboratory Rat

Biology and Diseases

1st Edition - January 1, 1979

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  • Editors: Henry J. Baker, J. Russell Lindsey, Steven H. Wesibroth
  • eBook ISBN: 9781483268613

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The Laboratory Rat, Volume I: Biology and Diseases focuses on the use of rats in specific areas of research, ranging from dental research to toxicology. The first part of this book retraces the biomedical history of early events and personalities involved in the establishment of rats as a leading laboratory animal. The taxonomy, genetics and inbred strains of rats are also elaborated. The next chapters illustrate the hematology, clinical biochemistry, and anatomical and physiological features of the laboratory rat. This text concludes with a description of infectious diseases that may be contracted from laboratory and/or wild rats. This volume is a good source for commercial and institutional organizations involved in producing rats for research use, specialists in laboratory animal, animal care and research technicians, as well as students in graduate and professional curricula.

Table of Contents

  • List of Contributors


    Contents of Volume II

    Chapter 1 Historical Foundations

    I. Origin of the Laboratory Rat

    II. The Wistar Institute

    III. Nutrition and Biochemistry

    IV. Endocrinology and Reproductive Physiology

    V. Cancer Research Institutes

    VI. Behavioral Research

    VII. Genetics

    VIII. Other Stocks of Rats

    IX. Genealogy of Major Rat Stocks and Strains

    X. Some Key Events after World War II

    XI. Information Requested


    Chapter 2 Taxonomy and Genetics

    I. Introduction

    II. Taxonomy and Geographical Distribution

    III. Adaptation to the Laboratory

    IV. Genetics

    V. Chromosome Mapping

    VI. Cytogenetics

    VII. Inbred Strains


    Chapter 3 Inbred Strains

    I. Introduction

    II. Nomenclature Rules


    Chapter 4 Morphophysiology

    I. Introduction

    II. General Appearance

    III. The Digestive System

    IV. Respiratory System

    V. Cardiovascular System

    VI. Urinary and Reproductive Systems

    VII. Endocrine System

    VIII. Nervous System

    IX. Special Sense Organs


    Chapter 5 Hematology and Clinical Biochemistry

    I. Introduction

    II. Sources of Variation

    III. Microtechniques

    IV. Quantities and Units

    V. Hematology

    VI. Clinical Biochemistry


    Chapter 6 Nutrition

    I. Introduction

    II. Dietary Considerations in Experimental Studies

    III. Nutrient Requirements


    Chapter 7 Reproduction and Breeding

    I. Introduction

    II. Biotic Aspects

    III. Nutrition

    IV. Spatial Aspects

    V. Climatic Aspects

    VI. Temporal Aspects

    VII. Management


    Chapter 8 Housing to Control Research Variables

    I. Introduction

    II. Physical Factors Affecting Biological Response

    III. Chemical Factors Affecting Biologic Response

    IV. Microbial Factors Affecting Biologic Response

    V. Ethical and Legal Considerations


    Chapter 9 Bacterial and Mycotic Diseases

    I. Introduction

    II. Bacterial Diseases

    III. Mycotic Diseases


    Chapter 10 Mycoplasmal and Rickettsial Diseases

    I. Introduction

    II. Mycoplasmal Diseases

    III. Rickettsial Diseases


    Chapter 11 Viral Diseases

    I. Introduction

    II. DNA Viruses

    III. RNA Viruses

    IV. Unclassified Viruses or Viruslike Agents

    V. Experimental Viral Infections

    VI. Collection of Samples for Serological Tests and Virus

    VII. Isolation

    VIII. General Comments on the Detection, Diagnosis, and

    IX. Control of Viral Infections


    Chapter 12 Parasitic Diseases

    I. Introduction

    II. Parasites of Parenteral Systems

    III. Parasites of the Alimentary System

    IV. Parasites of the Integument


    Chapter 13 Neoplastic Diseases

    I. Introduction

    II. Integumentary System

    III. Musculoskeletal System

    IV. Respiratory System

    V. Cardiovascular System

    VI. Digestive System

    VII. Endocrine System

    VIII. Hematopoietic System

    IX. Urinary System

    X. Female Reproductive System

    XI. Mammary Gland

    XII. Male Reproductive System

    XIII. Nervous System


    Chapter 14 Lesions Associated with Aging

    I. Introduction

    II. Major Age-Associated Lesions

    III. Influence of Diet on Longevity and Age-Associated Lesions

    IV. Other Age-Associated Lesions


    Chapter 15 Health Hazards for Man

    I. Introduction

    II. Allergy

    III. Bites

    IV. Bacterial Diseases

    V. Rickettsial Diseases

    VI. Viral Diseases

    VII. Protozoan Diseases

    VIII. Helminth Infections

    IX. Arthropod Infestations

    X. Mycoses

    XI. Conclusion


    Appendix 1 Selected Normative Data

    Appendix 2 Drugs and Dosages

    Subject Index

Product details

  • No. of pages: 450
  • Language: English
  • Copyright: © Academic Press 1979
  • Published: January 1, 1979
  • Imprint: Academic Press
  • eBook ISBN: 9781483268613

About the Editors

Henry J. Baker

J. Russell Lindsey

Steven H. Wesibroth

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