The Laboratory Mouse

Among animals used in research, teaching and testing, mice are now widely recognized as the most important model for human diseases and disorders. They comprise the majority of all experimental mammals and tend to be the model of choice used for research into many diseases/disorders including cancer, heart disease, asthma, Alzheimer’s, Down syndrome, deafness, osteoporosis, obesity, diabetes and even mental health research. Additionally the laboratory mouse continues to play a widely publicized vital role in the human genome project.

One of the most time-consuming activities in research laboratories is looking up information specific to the species or strain of animal being used. This book, part of the highly successful Handbook of Experimental Animals series, allows the user quick access to any point of interest on the mouse as an experimental model.

• Edited by Hans Hedrich, Hannover Medical School
• Comprehensive reference source written by international experts
• Well-illustrated with high quality detailed images
• Two-color, user-friendly format combined with color plate sections

Researchers and students in biological, veterinary and medical sciences, as well as researchers in the pharmaceutical industry.

History, Development and Genetics of the Mouse as a Laboratory Model Origin of the Laboratory Mouse and Related Historical Foundations Strain, Stock and Mutants Mouse Genomics Generation of Mouse Mutants by Sequence Information Driven and Random Mutagenesis The Mouse as an Animal Model for Human Diseases The Mouse in Preclinical Safety Studies

Anatomy and Developmental Biology Gross Anatomy Normative Histology of Organs Imaging Introduction to Early Mouse Development

Pathophysiology (including non-infectious diseases) Skin and Adnexes of the Laboratory Mouse Cardiovascular System Respiratory Tract Gastrointestinal System and Metabolism Inbred Mouse Models for Autoimmune Disease Hematology of the Mouse The Social Behaviour of Mice and its Sensory Control Neuroendocrine – Immune Network in Stress Circadian Rhythms of the Mouse Gerontology Diversity of Spontaneous Neoplasms in Commonly Used Inbred Strains and Stock of Laboratory Mice

Infectious Agents and Diseases Viral Infections

Animal Husbandry and Production Housing and Maintenance Gnotobiology and Breeding Techniques Assisted Reproduction and Cryopreservation Health Monitoring Nutrition of Laboratory Mice

Procedures Legal Regulations for the Protection of Animals Used for Scientific Experiments Necropsy Methods Handling and Restraint Routes of Administration Collection of Body Fluids Anaesthesia, Analgesia and Euthanasia