The Kidney

The Kidney

From Normal Development to Congenital Disease

1st Edition - February 14, 2003

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  • Editors: Peter Vize, Adrian S. Woolf, Jonathan Bard
  • Hardcover ISBN: 9780127224411
  • eBook ISBN: 9780080521541

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Description

Organogenesis of the kidney has been intensely studied for over a century. In recent years advances in molecular techniques have not only made great inroads into exploring the genetic regulation of this complex process but also began to unravel the molecular basis of many forms of congenital kidney disease. This book is a comprehensive study on these findings and the only book available with such in depth coverage of the kidney.

Key Features

  • Hundreds of color figures depicting key events in all aspects of kidney development
  • Full coverage of the genetic and cellular basis of kidney development
  • Analysis of the genetic basis of the major congenital kidney diseases

Readership

Nephrologists, cell and developmental biologists, hematologists, and clinicians interested in kidney disease

Table of Contents

  • SECTION 1: EMBRYONIC KIDNEYS AND MODELS
    1. Introduction: the embryonic kidneys and other nephrogenic models
    2. Development of the Malpighian tubules in Drosophila melanogaster
    3. Induction, development and physiology of the pronephric tubules
    4. Formation of the nephric duct
    5. The pronephric glomus and vasculature
    6. Development of the mesonephric kidney
    7. 3-Dimensional anatomy of mammalian mesonephroi
    8. The Molecular control of pronephros development- an Overview
    9. Embryological, genetic and molecular tools for investigating embryonic kidney development

    SECTION 2: THE ADULT KIDNEYS
    10. Introduction
    11. Anatomy and Histology of the Human Urinary System
    12. Development of the Ureteric Bud
    13. The Fates of the Metanephric Mesenchyme
    14. The Formation and Development of Nephrons
    15. Establishment of polarity in epithelial cells of the developing nephron
    16. Development of the Glomerular Capillary and its Basement Membrane
    17. The development of kidney blood vessels
    18. The Development of function in the metanephric kidney
    19. Experimental methods for studying urogenital development
    20. Overview: The Molecular Basis of Kidney Development

    SECTION 3: CONGENITAL DISEASE
    21. Maldevelopment of the Human Kidney and Lower Urinary Tract: an Overview
    22. Wilms' Tumor and related disorders
    23. Pax-2 and Renal-Coloboma Syndrome
    24. Polycystic Kidney Disease, von Hippel Lindau and Tuberous sclerosis
    26. Renal Cell Carcinoma: The Human Disease
    27. The Tubule
    28. Diseases of the Glomerular Filtration Barrier: Alport Syndrome and Congenital Nephrosis (NPHS1)
    29. Congenital Kidney Diseases: Prospects for New Therapies

Product details

  • No. of pages: 592
  • Language: English
  • Copyright: © Academic Press 2003
  • Published: February 14, 2003
  • Imprint: Academic Press
  • Hardcover ISBN: 9780127224411
  • eBook ISBN: 9780080521541

About the Editors

Peter Vize

Peter D. Vize uses the many advantages of model systems to explore the very first events in kidney development. These studies have characterized both the inductive signals that initiate kidney formation and also characterized the genetic response to these signals.

Affiliations and Expertise

University of Calgary, Canada and University of Texas, U.S.A.

Adrian S. Woolf

Adrian Woolf heads the Nephro-Urology Unit at the Institute of Child Health. His research focuses on defining the biological basis of low numbers of glomeruli; on elucidating the normal mechanisms of renal vessel differentiation; vascular remodeling in kidney disease; and the study of the clinical and genetic aspects of primary vesicoureteric reflux, duplex kidneys, glomerulocystic diseases (oral-facial-digital type 1 and the Renal Cysts and Diabetes syndromes), Bardet-Biedl syndrome, Kallmann's syndrome etc.

Affiliations and Expertise

University College London, U.K.

Jonathan Bard

Jonathan Bard is a developmental biologist whose main interests are kidney development, the generation of structures in embryos and bioinformatics. He currently works on the cellular basis of nephron formation and on making ontologies of vertebrate anatomy for gene-expression databases (see http://genex.hgu.mrc.ac.uk" target="_blank">http://genex.hgu.mrc.ac.uk)

Affiliations and Expertise

University of Edinburgh, U.K.

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