This volume brings together an international group of clinicians and clinical scientists to contribute to a state-of the-art review of the underlying pathogenic mechanisms, methods of clinical assessment, classification and diagnosis of renal disease, combined with a detailed overview of treatment strategies. An essential reference source for all those involved with the care of patients with renal involvement in systemic autoimmune disease, and for those contributing to research into the underlying pathogenic mechanisms in these disorders.


Internal medicine and renal physicians, rheumatologists, paediatricians, clinical immunologists and general practitioners

Table of Contents

Pathogenic Mechanisms Pathogenesis of renal disease – autoimmunity Pathogenesis of renal disease – complement Pathogenesis of renal disease – cytokines & other soluble factors Pathogenesis of renal disease – cellular mechanisms Pathogenesis of renal disease – renal cell response to injury Renal toxicity of drugs used in systemic AI disease The vasculitides AASV – mechanisms AASV – clinical features and treatment Large and medium vessel vasculitis – mechanisms Large and medium vessel vasculitis – clinical features & Rx Anti-GBM – mechanisms, clinical features and treatment Cryoglobulinaemic vasculitis HSP HUS/TTP The connective tissue diseases SLE – mechanisms SLE – renal involvement SLE – treatment APS Sjögrens syndrome Systemic sclerosis Amyloidosis Miscellaneous (Inflammatory arthritis, sarcoid, Behcets)


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© 2008
Elsevier Science
eBook ISBN:
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About the editors

Justin Mason

Affiliations and Expertise

Professor of Vascular Rheumatology, Bywaters Centre for Vascular Inflammation, Imperial College London, Hammersmith Hospital, London, UK

Charles Pusey

Affiliations and Expertise

Renal Section, Division of Medicine, Imperial College London, Hammersmith Hospital, U.K.