The Inflammatory Process

The Inflammatory Process

Volume 2

2nd Edition - January 1, 1973

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  • Editors: Benjamin W. Zweifach, Lester Grant, Robert T. McCluskey
  • eBook ISBN: 9781483220802

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The Inflammatory Process, Second Edition is an account of the inflammatory process and covers topics ranging from microvascular aspects of tissue injury and capillary permeability to rheologic factors in inflammation. The effects of inflammation on the lymphatic system are also explored, along with the sticking and emigration of white blood cells in inflammation. Comprised of 11 chapters, this volume begins with an overview of vascular events in the inflammatory process, paying particular attention to the microvascular aspects of tissue injury and structural and physiological considerations in capillary permeability. The rheology of inflammation and the effects of inflammation on the lymphatic system are also examined. Subsequent chapters focus on the natural role of amines, polypeptides, and proteases in the inflammatory process; mediation of increased vascular permeability in inflammation; and hemostatic mechanisms in tissue injury. The book concludes with an analysis of thrombosis as an initiator of inflammation and as a complication of inflammation, and how it can be prevented. This monograph will be of interest to practitioners in fields ranging from biochemistry to pathology, bacteriology, physiology, and immunology.

Table of Contents

  • List Of Contributors


    Preface to First Edition

    Contents of Other Volumes

    Part I. Vascular Events in the Inflammatory Process

    Chapter 1. Microvascular Aspects of Tissue Injury

    I. General Aspects of Reaction

    II. Specific Components

    III. Summary


    Chapter 2. Capillary Permeability

    I. Structural Consideration

    I. Introduction

    II. Permeability of Capillaries

    III. Capillary Structure

    IV. Discussion of Various Mechanisms Proposed for the Control of Capillary Permeability

    V. Summary and Conclusions


    Chapter 3. Capillary Permeability

    II. Physiological Considerations

    I. Introduction

    II. General Outline of Capillary Permeability

    III. Modes of Transport through Capillary Walls

    IV. Methods for Studying Diffusion Permeability of Capillaries


    Chapter 4. Capillary Permeability

    III. Connective Tissue

    I. Historical Perspective

    II. Morphology and Composition of Connective Tissue

    III. Organization and Functions of Connective Tissue

    IV. Physical Chemistry of Connective Tissue

    V. Role of the Connective Tissue in Vascular Exchange

    VI. Reaction of Connective Tissue of Certain Agents

    VII. Connective Tissue Homeostasis


    Chapter 5. Rheologic Factors in Inflammation

    I. Introduction

    II. Rheology of Normal Blood

    III. Rheology of Inflammation

    IV. Summary


    Chapter 6. The Lymphatic System in Inflammation

    I. Introduction

    II. Structure

    III. Permeable Paths through the Lymphatic Wall

    IV. Functioning of the Lymphatic System

    V. Effects of Inflammation on the Lymphatic System

    VI. Effects of the Lymphatic System on Inflammation

    VII. Therapeutic Measures


    Chapter 7. The Sticking and Emigration of White Blood Cells in Inflammation

    I. Introduction

    II. History of the Problem

    III. Fate of Emigrated Cells in the Extravascular Tissue

    IV. The Influence of pH on the Emigration of White Cells

    V. Relationship Between White Cell Sticking and Vascular Permeability

    VI. Chemotaxis

    VII. Electrochemical Factors

    VIII. Summary


    Chapter 8. Chemical Mediators

    I. Introduction

    II. Early Vascular Events in Inflammation

    III. Endogenous Mediators of the Vascular Events

    IV. Evidence for the Natural Role of Amines, Polypeptides, and Proteases in the Inflammatory Process

    V. Inflammatory Response in Various Organs

    VI. Conclusions


    Chapter 9. Mediation of Increased Vascular Permeability in Inflammation

    I. Introduction

    II. Acute Inflammation

    III. Trigger Mechanisms

    IV. Leukocytes as Mediators

    V. The Case against Mediators

    VI. Delayed Hypersensitivity

    VII. Unifying Hypothesis of Inflammation

    VIII. Conclusions

    Note Added in Proof


    Part II. Hematological Considerations

    Chapter 10. Hemostatic Mechanisms in Tissue Injury

    I. Introduction

    II. The Hemostatic Plug

    III. Vascular and Tissue Factors in Hemostasis

    IV. Hemostasis as a Whole


    Chapter 11. Thrombosis

    I. Thrombosis as an Initiator of Inflammation

    II. Thrombosis as a Complication of Inflammation

    III. Prevention of Thrombosis


    Author Index

    Subject Index

Product details

  • No. of pages: 436
  • Language: English
  • Copyright: © Academic Press 1973
  • Published: January 1, 1973
  • Imprint: Academic Press
  • eBook ISBN: 9781483220802

About the Editors

Benjamin W. Zweifach

Lester Grant

Robert T. McCluskey

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