The Inflammatory Process - 2nd Edition - ISBN: 9780127834016, 9781483220796

The Inflammatory Process

2nd Edition

Volume 1

Editors: Benjamin W. Zweifach Lester Grant Robert T. McCluskey
eBook ISBN: 9781483220796
Imprint: Academic Press
Published Date: 1st January 1974
Page Count: 670
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The Inflammatory Process, Second Edition is an account of the inflammatory process and covers topics ranging from cell surface phenomena and connective tissue to the role of the formed elements of the blood in inflammatory states, particularly in the light of the rapidly burgeoning literature on platelet physiology. The life history and functional capacities of leukocytes are also examined, along with chemotaxis, phagocytosis, and the mechanisms responsible for tissue damage in inflammation.

Comprised of 10 chapters, this volume begins with an overview of the experimental approach to the study of inflammation, followed by a discussion on the biochemistry of the mammalian plasma membrane. The reader is then introduced to cell injury; chemotaxis; phagocytosis; and lysosomal mechanisms in the inflammatory process. Subsequent chapters deal with the inflammatory process at the cellular level, paying particular attention to neutrophil leukocytes; the metabolism and physiology of mononuclear phagocytes; the role of platelets in inflammatory reactions; and structural and biochemical characteristics of mast cells.

This book will be of interest to practitioners in fields ranging from biochemistry to pathology, bacteriology, physiology, and immunology.

Table of Contents

List of Contributors


Preface to First Edition

Contents of Other Volumes

Part I. Inflammatory Process at the Molecular Level

Chapter 1. The Experimental Approach to the Study of Inflammation

I. Introduction

II. The Gross Pathology of Inflammation

III. The Light Microscope and the Study of Inflammation

IV. Bacteriology and Immunology

V. Chemotaxis

VI. Phagocytosis

VII. The Physiological Approach to Problems of Inflammation

VIII. Chemical Mediators of Inflammation

IX. The Electron Microscope and Changes in Ultrastructure

X. Conclusions

XI. Summary


Chapter 2. Biochemistry of the Mammalian Plasma Membrane

I. Introduction

II. Morphological Background

III. The Chemical and Enzymatic Composition of Plasma Membranes

IV. Isolation of Plasma Membrane Proteins

V. Biosynthesis of the Plasma Membrane

VI. Molecular Organization of the Plasma Membrane


Chapter 3. Cell Injury

I. Introduction

II. Progression of Changes in Lethal Injury

III. Chronic Cell Injury


Chapter 4. Lysosomal Mechanisms in the Inflammatory Process

I. Introduction

II. Formation, Classification, and Fate of Lysosomes

III. Structure and Contents of Lysosomes

IV. Morphology

V. Functions of Lysosomes


Chapter 5. Chemotaxis

I. Introduction

II. Chemotaxis in Bacteria

III. Chemotaxis in Plants

IV. Chemotaxis in Lower Animal Forms

V. Tissue Culture Studies: Chemotactic Factors in Tumors

VI. Chemotaxis in White Blood Cells

VII. Possible Modifying Mechanisms in Chemotaxis

VIII. Conclusion

IX. Summary



Chapter 6. Phagocytosis

I. Introduction

II. General Aspects of Phagocytosis

III. Metabolism during Phagocytosis

IV. Clinical Abnormalities of Cellular Host Defense



Part II. Inflammatory Process at the Cell Level

Chapter 7. Neutrophil Leukocytes

I. Introduction

II. Terminology and Morphology

III. Formation, Distribution, and Fate of Neutrophils

IV. The Nature of Neutrophil Granules

V. Metabolism of Neutrophils

VI. Physiology of Neutrophils

VII. Neutrophil Functions

VIII. Abnormal Neutrophils


Chapter 8. The Metabolism and Physiology of the Mononuclear Phagocytes

I. Introduction

II. Life History

III. Morphology

IV. Maturation

V. Endocytosis

VI. Macrophages and Host Defense

VII. Macrophage and the Immune Response


Chapter 9. Platelets

I. Introduction

II. Reactions in Hemostasis: Effects of Thrombin, Collagen, Subendothelial Microfibrils, ADP, and Epinephrine

III. Reaction of Platelets with Foreign Materials

IV. Inhibitors of Platelet Aggregation and Release: Similarities Between the Reactions of Platelets and Other Cells

V. Platelets in Other Inflammatory Reactions


Chapter 10. Structural and Biochemical Characteristics of Mast Cells

I. Introduction

II. Origin and Distribution of Mast Cells

III. Normal Tissue Mast Cells; Neoplastic Mast Cells

IV. Mast Cell Cytology

V. Biochemistry of the Mast Cells

VI. Functional View of the Tissue Mast Cell

VII. Mast Cells in Pathological Disorders

VIII. Concluding Remarks


Author Index

Subject Index


No. of pages:
© Academic Press 1974
Academic Press
eBook ISBN:

About the Editor

Benjamin W. Zweifach

Lester Grant

Robert T. McCluskey

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