The Inflammatory Process

The Inflammatory Process

Volume 1

2nd Edition - January 1, 1974

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  • Editors: Benjamin W. Zweifach, Lester Grant, Robert T. McCluskey
  • eBook ISBN: 9781483220796

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The Inflammatory Process, Second Edition is an account of the inflammatory process and covers topics ranging from cell surface phenomena and connective tissue to the role of the formed elements of the blood in inflammatory states, particularly in the light of the rapidly burgeoning literature on platelet physiology. The life history and functional capacities of leukocytes are also examined, along with chemotaxis, phagocytosis, and the mechanisms responsible for tissue damage in inflammation. Comprised of 10 chapters, this volume begins with an overview of the experimental approach to the study of inflammation, followed by a discussion on the biochemistry of the mammalian plasma membrane. The reader is then introduced to cell injury; chemotaxis; phagocytosis; and lysosomal mechanisms in the inflammatory process. Subsequent chapters deal with the inflammatory process at the cellular level, paying particular attention to neutrophil leukocytes; the metabolism and physiology of mononuclear phagocytes; the role of platelets in inflammatory reactions; and structural and biochemical characteristics of mast cells. This book will be of interest to practitioners in fields ranging from biochemistry to pathology, bacteriology, physiology, and immunology.

Table of Contents

  • List of Contributors


    Preface to First Edition

    Contents of Other Volumes

    Part I. Inflammatory Process at the Molecular Level

    Chapter 1. The Experimental Approach to the Study of Inflammation

    I. Introduction

    II. The Gross Pathology of Inflammation

    III. The Light Microscope and the Study of Inflammation

    IV. Bacteriology and Immunology

    V. Chemotaxis

    VI. Phagocytosis

    VII. The Physiological Approach to Problems of Inflammation

    VIII. Chemical Mediators of Inflammation

    IX. The Electron Microscope and Changes in Ultrastructure

    X. Conclusions

    XI. Summary


    Chapter 2. Biochemistry of the Mammalian Plasma Membrane

    I. Introduction

    II. Morphological Background

    III. The Chemical and Enzymatic Composition of Plasma Membranes

    IV. Isolation of Plasma Membrane Proteins

    V. Biosynthesis of the Plasma Membrane

    VI. Molecular Organization of the Plasma Membrane


    Chapter 3. Cell Injury

    I. Introduction

    II. Progression of Changes in Lethal Injury

    III. Chronic Cell Injury


    Chapter 4. Lysosomal Mechanisms in the Inflammatory Process

    I. Introduction

    II. Formation, Classification, and Fate of Lysosomes

    III. Structure and Contents of Lysosomes

    IV. Morphology

    V. Functions of Lysosomes


    Chapter 5. Chemotaxis

    I. Introduction

    II. Chemotaxis in Bacteria

    III. Chemotaxis in Plants

    IV. Chemotaxis in Lower Animal Forms

    V. Tissue Culture Studies: Chemotactic Factors in Tumors

    VI. Chemotaxis in White Blood Cells

    VII. Possible Modifying Mechanisms in Chemotaxis

    VIII. Conclusion

    IX. Summary



    Chapter 6. Phagocytosis

    I. Introduction

    II. General Aspects of Phagocytosis

    III. Metabolism during Phagocytosis

    IV. Clinical Abnormalities of Cellular Host Defense



    Part II. Inflammatory Process at the Cell Level

    Chapter 7. Neutrophil Leukocytes

    I. Introduction

    II. Terminology and Morphology

    III. Formation, Distribution, and Fate of Neutrophils

    IV. The Nature of Neutrophil Granules

    V. Metabolism of Neutrophils

    VI. Physiology of Neutrophils

    VII. Neutrophil Functions

    VIII. Abnormal Neutrophils


    Chapter 8. The Metabolism and Physiology of the Mononuclear Phagocytes

    I. Introduction

    II. Life History

    III. Morphology

    IV. Maturation

    V. Endocytosis

    VI. Macrophages and Host Defense

    VII. Macrophage and the Immune Response


    Chapter 9. Platelets

    I. Introduction

    II. Reactions in Hemostasis: Effects of Thrombin, Collagen, Subendothelial Microfibrils, ADP, and Epinephrine

    III. Reaction of Platelets with Foreign Materials

    IV. Inhibitors of Platelet Aggregation and Release: Similarities Between the Reactions of Platelets and Other Cells

    V. Platelets in Other Inflammatory Reactions


    Chapter 10. Structural and Biochemical Characteristics of Mast Cells

    I. Introduction

    II. Origin and Distribution of Mast Cells

    III. Normal Tissue Mast Cells; Neoplastic Mast Cells

    IV. Mast Cell Cytology

    V. Biochemistry of the Mast Cells

    VI. Functional View of the Tissue Mast Cell

    VII. Mast Cells in Pathological Disorders

    VIII. Concluding Remarks


    Author Index

    Subject Index

Product details

  • No. of pages: 670
  • Language: English
  • Copyright: © Academic Press 1974
  • Published: January 1, 1974
  • Imprint: Academic Press
  • eBook ISBN: 9781483220796

About the Editors

Benjamin W. Zweifach

Lester Grant

Robert T. McCluskey

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