The Impact of Protein Chemistry on the Biomedical Sciences
Free Global Shipping
No minimum orderDescription
The Impact of Protein Chemistry on the Biomedical Sciences focuses on the structure, function, and synthesis of proteins. This book examines the various approaches on how amino acids are polymerized in vitro, which involves the physical, chemical, immunological, enzymologic, biosynthetic, and organic synthetic techniques. Comprised of five parts encompassing 27 chapters, this book starts with an overview of Christian B. Anfinsen’s role in the development of protein chemistry and the training of scientists who have advanced their experiences in his laboratory to pioneer in the field of biological and medical sciences. This text then examines the synthesis of albumin molecule in the bloodstream as it carries cystine, hematin, bilirubin, fatty acids, and aromatic compounds. Other chapters discuss the kinetic experiments of hydrogen exchange in aqueous solution between peptide molecules and solvent water. This text also introduces the reader to the lipoprotein–atherosclerosis connection by studying the metabolism of plasma lipoproteins. This book is a valuable source of information for biologists, chemical biologists, scientists, and students.
Table of Contents
Contributors and Participants
Preface
Introduction: The Anfinsen Series
Christian Anfinsen and The National Institutes of Health
Part I. Research in Perspective
1. Historical Perspective of Biomedical Research
A. Baird Hastings
2. Basic Research as an Investment in the Nation's Future
I. Background
II. A Glimpse of Activities in the OSTP
III. Closing Remarks
References
Part II. Protein Chemistry
3. From Polypeptide Chemistry to Muscle Contraction
Text
References
4. Serum Albumin: Adventures of a Circulating Protein
I. Features of Albumin
II. Mode of Biosynthesis of Albumin
III. Nature of the Intracellular Albumin: Proalbumin
IV. Albumin in the Circulation
V. Fate of Albumin
VI. Conclusion
References
5. What Does Hydrogen Exchange Tell Us about Proteins?
I. The Hydrogen-Exchange Method
II. Interpretation of Exchange Rates
References
6. The Mechanism of Protein Folding
I. Equilibrium Ensembles of Protein Conformations
II. Information for Cooperative Folding
III. Linkage of Interatomic Interactions
IV. Determinant of the Ordered Structure
V. Dynamic Equilibrium of Folding and Unfolding
VI. Cytochrome c Fragment-Complementing System
VII. Energy Barrier for Unfolding
VIII. Concluding Remarks
References
7. Chemical Syntheses and Biological Activities of Cyclic Peptides
I. General Features of Microbial Peptides
II. Syntheses and Antibacterial Activities of Gramicidin S and Its Analogs
III. Syntheses and Necrotic Activities of AM Toxins and Their Analogs
References
8. Affinity Labeling: From Nuclease to Cells
I. Affinity Labeling
II. Affinity Labeling of Nuclease
III. Affinity Labeling of Antibodies
IV. Affinity Labeling of Ribosomes
V. Affinity Labeling of Hormone Carrier and Receptor Proteins
VI. Affinity Labeling of Cells
VII. Conclusions
References
9. Structural Bases of Biological Function: From Nucleases to Neurophysins
I. Heritage of the Observation of Spontaneous Self-Assembly
II. Semisynthesis as a Probe of the Sequence Code
III. Biosynthetic Origin of Peptides and Proteins
IV. Concluding Remarks
References
10. Staphylococcal Nuclease, a Calcium-Binding Protein: Path to the Vitamin K-Dependent Blood Coagulation Proteins
Text
References
Part III. Immunology
11. Molecular Evolution, Antibody Formation, and Embryogenesis
I. Molecular Evolution
II. Antibody Formation
III. Embryogenesis
IV. Status of the Embryogenesis Problem
References
12. The Combining Site of Antibodies: From the Protein to the Gene
I. Affinity Labeling of the Antibody Combining Site
II. Preparation of Fv Fragments
III. Model-Building Studies
IV. Structure and Diversity of Immunoglobulin VH Genes
V. Sequence of the 5' Noncoding and Leader Regions
VI. Sequence of VH Coding Region and the Recombination Signals
VII. Evolutionary Diversity of VH Genes
VIII. Immune VH Gene Repertoire Is Rich in Pseudogenes
IX. Conclusion
References
13. Protein Conformation and Biological Function: From Ribonuclease to Antigens and Antibodies
I. From Ribonuclease to Antibodies
II. Role of Conformation in Antigen Specificity
III. Toward Synthetic Vaccines: The MS-2 Bacteriophage Story
IV. Combined Use of Synthetic Antigens and Synthetic Adjuvants
V. Conclusion
References
14. Antigenic Determinants of Proteins and Synthetic Vaccines
I. Neutralization of Biologically Active Materials by Antibodies
II. The "Loop" Peptide: A Defined Antigenic Region of Lysozyme
III. Synthetic Peptides Inducing Antiviral Response
IV. Synthetic Vaccines?
References
15. Staphylococcal Nuclease as a Model Antigen
Text
References
16. Autoimmunity to Acetylcholine Receptor and Its Significance for Myasthenia Gravis
I. Acetylcholine Receptor, Myasthenia Gravis, and Experimental Autoimmune Myasthenia Gravis
II. Regulation of Experimental Autoimmune Myasthenia Gravis by Denatured Acetylcholine Receptor
III. Regulation of Experimental Autoimmune Myasthenia Gravis by Antiidiotypes
IV. Monoclonal Antibodies
V. Conclusion
References
17. The Antibody Combining Site: A Basis for a New Pharmacology
I. Review of the Potential Application of Antibodies to Human Pharmacology
II. Antibodies as Drugs
References
Part IV. Metabolism and Endocrinology
18. Lipoproteins and Atherosclerosis: A Problem in Cell Biology
I. The Anfinsen—Lipoprotein Lipase Connection
II. Approaches to Research on the Atherosclerosis-Lipoprotein Connection
III. Cells Involved in Low-Density Lipoprotein Degradation in Vivo
IV. Pathways Available for Catabolism of Native Low-Density Lipoprotein
V. Pathways for Catabolism of Modified Forms of Low-Density Lipid
VI. Role of Other Lipoproteins
References
19. Protein Chemistry and the Cardiologist
Text
References
20. Regulation of Cyclic Nucleotide Metabolism: From Proteins to Cyclic Nucleotides and Back
I. Cyclic Nucleotides and Some Enzymes That Metabolize Them
II. Adenylate Cyclase and Choleragen
III. ADP-Ribosylation of Proteins and the Future
References
21. Activation of Adenylate Cyclase in the Adrenal Cortex
I. The Nuclease Problem
II. The ACTH Problem
III. Concluding Remarks
References
22. Studies of Human Chorionic Gonadotropin: Implications for Fertility Research
I. Purification
II. Structure
III. Precursor Structure
IV. Biological Application
V. Immunochemical Distinction between hCG and hLH
References
23. Excursions of a Protein Vagabond: From Nuclease to Affinity Chromatography to Hormone Receptors and Membranes
Text
References
Part V· Genetics
24. Early Embryonic Development: Normal and Abnormal
Text
References
25. Molecular Regulation in Muscle Development
I. Lessons from Protein Folding and Virus Assembly
II. The Genetic Approach: From Phage Morphogenesis to Muscle Development
III. Structural Interactions of Myosin during the Assembly of Thick Filaments
IV. Coordinate Synthesis of Myosin Forms during Morphogenesis of Muscle
V. Gene Switching during Embryonic Muscle Differentiation
References
26. Interferon: Past, Present, and Future
I. Past and Present
II. Future
References
27. Parathyroid Hormone: Chemistry, Biosynthesis, and Mode of Action
I. Introduction
II. Physiology of Hormone Action
III. Isolation and Sequence Analysis
IV. Biosynthesis
V. Metabolism
VI. Mechanism of Action and Structure-Activity Relations of Parathyroid Hormone
VII. Summary
References
Bibliography
Index
Product details
- No. of pages: 448
- Language: English
- Copyright: © Academic Press 1984
- Published: January 1, 1984
- Imprint: Academic Press
- eBook ISBN: 9780323149891
About the Editor
Alan Schechter
Ratings and Reviews
There are currently no reviews for "The Impact of Protein Chemistry on the Biomedical Sciences"