The Immune System

The Immune System

Genes, Receptors, Signals

1st Edition - January 1, 1974

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  • Editors: Eli E. Sercarz, Alan R. Williamson, C. Fred Fox
  • eBook ISBN: 9781483277400

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The Immune System: Genes Receptors, Signals provides information pertinent to the complexity of immune mechanisms. This book describes the immune response genes and products, which point to another multigene system controlling immune responsiveness. Organized into 37 chapters, this book begins with an overview of the details of antibody structure that continue to be of importance to an understanding of the regulation of the immune reactions. This text then examines the evidence that individual antibody species are capable of binding many structurally dissimilar haptens. Other chapters consider the conceptual framework generally accepted by immunologists, which states that antibodies are specific for the antigen used to elicit the immune response. This book discusses as well the mechanism underlying the biosynthesis of antibody binding sites, which is unprecedented in its adaptability. The final chapter deals with the genetic controls of specific immune responses. This book is a valuable resource for immunologists and research workers.

Table of Contents

  • List of Contributors



    I. V Region: Structure and Genetics-Molecular Basis of Antibody Specificity

    Antibody Structure and the Immune Response

    The Three-Dimensional Structure of the Antigen Binding Site of McPC 603 Protein

    Kinetic Mapping of Antibody Binding Sites

    Multispecificity of the Antibody Combining Region and Antibody Diversity

    Polyfunctional Antibody Combining Regions

    II. V Region: Structure and Genetics-Genetic Control of Variable Region Structure

    A Study of V Region Genes Using Allotypic and Idiotypic Markers

    First Order Considerations in Analyzing the Generator of Diversity

    Antibody Diversity: An Assessment

    III. Lymphocyte Membranes and Surface Receptors-Molecular Characterization

    Molecular and Functional Properties of Lymphocyte Surface Immunoglobulin

    Alloantiserum Induced Blockade of IR Gene Product Function

    Further Characterization of Ia (Immune Response Region Associated) Antigen Molecules

    Receptors for Antigen on "b, T, B-T and NUL" Lymphocytes in Normal and "NUDE" Mice

    Cytophilic Properties of T Lymphocyte Membrane Associated Immunoglobulins

    In-Vitro Biosynthesis and Molecular Arrangement of Surface Immunoglobulin of Mouse Thymus Cells

    IV. Lymphocyte Membranes and Surface Receptors-Effects of Ligand Binding at the Cell Surface

    The Lymphocyte Plasma Membrane

    Probing Lymphocyte Membrane Organization

    Polyclonal Mitogens and the Nature of B Lymphocyte Activation Mechanisms

    V. B-Cell Activities-Molecular Genetics: mRNA Control and Mutations

    The Organization of Immunoglobulin Genes

    Quantitative Estimation of the mRNA for H-Chain Immunoglobulin

    Mutations in Mouse Myeloma Cells

    Spontaneous Mutation in Immunoglobulin Genes

    VI. B-Cell Activities-Development and Propagation of Clones

    Biography of the B Cell

    The Generation of Diversity within Single Clones of Antibody-Forming Cells

    B Memory Cells in the Propagation of Stable Clones of Antibody-Forming Cells

    Antigen Dependence of Clonal Memory

    VII. T Cell Effects on Other Cells-Suppressor T Cells

    Regulation of the Antibody Response to Type III Pneumococcal Polysaccharide by Thymic-Derived Cells

    Thymocyte Subpopulation with Suppressive Activity

    Suppressor T Cells in Low Zone Tolerance

    Antibody Induced Suppressor T-Cells

    T Cell Regulation: The "Second Law of Thymodynamics"

    VIII. T Cell Effects on Other Cells-Mediators and Matrices

    T Cell Factors in the Regulation of the B Cell Response

    Antigen Specific T Cell Factors and Their Role in the Regulation of T-B Interaction

    The Nature of the Signals Required for the Induction of Antibody Synthesis

    Idiotypic Receptors for Alloantigen on T Cells?

    IX. On-Off Signals: Cellular Discrimination and Genetic Control

    Manipulation of a Tolerant State: Cells and Signals

    The Role of Histocompatibility Gene Products in Cooperative Cell Interactions between T and B Lymphocytes

    Ir Genes and Antigen Recognition

Product details

  • No. of pages: 646
  • Language: English
  • Copyright: © Academic Press 1974
  • Published: January 1, 1974
  • Imprint: Academic Press
  • eBook ISBN: 9781483277400

About the Editors

Eli E. Sercarz

Alan R. Williamson

C. Fred Fox

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