The immune system

The immune system

1st Edition - March 28, 1989

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  • Author: Rodney Langman
  • eBook ISBN: 9780323158855

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9780124365858 The Immune System: Evolutionary Principle Guide our Understanding of this Complex Biological Defense System provides the conceptual framework of immunology and the evolutionary events that have shaped the understanding of the immune system. This book contains 10 chapters, and begins with a brief discussion on the evolutionary aspects of immunology considering the Darwinian principles of evolution. This topic is followed by a presentation of the selective pressures that are likely to have molded the immune system, as well as the laws of the immune system and their corollaries concerning host defense mechanism. The subsequent chapters are devoted to cellular components of the immune system, including the B and T cells, immunoglobulins, interleukins, major histocompatibility complex, and lymphoid organs. The structural information and the evolutionary events in these immune system components are provided. A chapter focuses on the evolutionary successful components of the inflammatory system. The concluding chapter deals with the conflicting conventional wisdoms on functional immune system. This book will prove useful to immunologists and research workers in immunology and related fields.

Table of Contents

  • Preface

    Foreword: Clippings from One Immunologist's Journal

    Chapter 1 Introduction

    I. What Makes An Immune System Work?

    II. The Language of Immunology

    III. Why Read On?

    Chapter 2 Evolutionary Origins of the Immune System

    I. An Essential Assumption: the Immune System Evolved from Amoebae

    II. Amoebae Begin to Fight Back Against Intracellular Parasites

    III. Specificity Demands One Function Per Cell

    IV. The Big Evolutionary Leap

    V. Two New Effector Functions: An Evolutionary Puzzle

    VI. Merging Evolution with the Present Immune System

    The Take-Home Message

    Chapter 3 the Self-Nonself Discrimination

    I. Two Laws of the Immune System and Their Corollaries

    II. A Requirement for Two Signals

    III. "Help": A Property of T Cells or B Cells?

    IV. From Principles to Practice

    V. Associative Antigen Recognition

    VI. Mononuclear Phagocytes and the Self-Nonself Discrimination

    VII. The Paradox of Essential Anti-Self Immunoglobins

    VIII. Acquired Self-Destruction

    The Take-Home Message

    Chapter 4 A Cells and Immunoglobins

    I. Immunoglobins as Proteins

    II. The Organization and Reorganization of Genes

    III. Receptors and Effectors

    IV. Diversity and Dispersion of Combining Sites

    V. Haplotype Exclusion

    VI. The Protecton: A Module of B-Cell Function

    The Take-Home Message

    Chapter 5 T Cells

    I. Defensive T Cells

    II. Regulatory T Cells

    III. Which T Cells Show Restricted Recognition?

    IV. How Is Restrictive Recognition Accomplished?

    V. the Phenomena of Restrictive Recognition

    VI. The Organization and Reorganization of VT Genes

    VII. The Size of a Functional T-Cell Repertoire

    The Take-Home Message

    Chapter 6 Interleukins

    I. Interleukins and the Self-Nonself Discrimination

    II. Interleukins and Killer T Cells

    III. Interleukins and B Cells

    IV. Immunological Memory

    The Take-Home Message

    Chapter 7 the MHC: Structure and Function

    I. The Gene Complex

    II. The CLASS I and CLASS II Gene Products

    III. The Polymorphism Problem

    IV. The "Immune Response" (IR-1) Gene Effect

    V. Antigen Processing

    The Take-Home Message

    Chapter 8 Nonimmune Effector Functions

    I. Complement

    II. Mononuclear Phagocytes

    III. Mast Cells, Platelets, Histamines, and Allergy

    The Take-Home Message

    Chapter 9 Lymphoid Organs

    I. An Overview

    II. The Thymus: A Special Organ for T Cells

    III. Lymphoid Follicles in Spleen and Nodes

    The Take-Home Message

    Chapter 10 Other Views

    View I. An Idiotype Network Regulates the Immune System

    View II. Suppression Regulates the Self-Nonself Discrimination

    View III. Restricting Elements Make the Self-Nonself Discrimination

    View IV. There Are Many Ways to Become Unresponsive to Self

    View V. T Cells Recognize an Interaction Antigen

    View VI. Antigen Processing Is Obligatory

    View VII. Receptor Aggregation Signals the B Cell

    The Take-Home Message


Product details

  • No. of pages: 256
  • Language: English
  • Copyright: © Academic Press 1989
  • Published: March 28, 1989
  • Imprint: Academic Press
  • eBook ISBN: 9780323158855

About the Author

Rodney Langman

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