The Immune System: Evolutionary Principle Guide our Understanding of this Complex Biological Defense System provides the conceptual framework of immunology and the evolutionary events that have shaped the understanding of the immune system.
This book contains 10 chapters, and begins with a brief discussion on the evolutionary aspects of immunology considering the Darwinian principles of evolution. This topic is followed by a presentation of the selective pressures that are likely to have molded the immune system, as well as the laws of the immune system and their corollaries concerning host defense mechanism. The subsequent chapters are devoted to cellular components of the immune system, including the B and T cells, immunoglobulins, interleukins, major histocompatibility complex, and lymphoid organs. The structural information and the evolutionary events in these immune system components are provided. A chapter focuses on the evolutionary successful components of the inflammatory system. The concluding chapter deals with the conflicting conventional wisdoms on functional immune system. This book will prove useful to immunologists and research workers in immunology and related fields.
Preface Foreword: Clippings from One Immunologist's Journal Chapter 1 Introduction I. What Makes An Immune System Work? II. The Language of Immunology III. Why Read On? Chapter 2 Evolutionary Origins of the Immune System I. An Essential Assumption: the Immune System Evolved from Amoebae II. Amoebae Begin to Fight Back Against Intracellular Parasites III. Specificity Demands One Function Per Cell IV. The Big Evolutionary Leap V. Two New Effector Functions: An Evolutionary Puzzle VI. Merging Evolution with the Present Immune System The Take-Home Message Chapter 3 the Self-Nonself Discrimination I. Two Laws of the Immune System and Their Corollaries II. A Requirement for Two Signals III. "Help": A Property of T Cells or B Cells? IV. From Principles to Practice V. Associative Antigen Recognition VI. Mononuclear Phagocytes and the Self-Nonself Discrimination VII. The Paradox of Essential Anti-Self Immunoglobins VIII. Acquired Self-Destruction The Take-Home Message Chapter 4 A Cells and Immunoglobins I. Immunoglobins as Proteins II. The Organization and Reorganization of Genes III. Receptors and Effectors IV. Diversity and Dispersion of Combining Sites V. Haplotype Exclusion VI. The Protecton: A Module of B-Cell Function The Take-Home Message Chapter 5 T Cells I. Defensive T Cells II. Regulatory T Cells III. Which T Cells Show Restricted Recognition? IV. How Is Restrictive Recognition Accomplished? V. the Phenomena of Restrictive Recognition VI. The Organization and Reorganization of VT Genes VII. The Size of a Functional T-Cell Repertoire The Take-Home Message Chapter 6 Interleukins I. Interleukins and the Self-Nonself Discrimination II. Interleukins and Killer T Cells III. Interleukins and B Cells IV
- No. of pages:
- © Academic Press 1989
- 28th March 1989
- Academic Press
- eBook ISBN: