Sociology, psychology, psychiatry, neuroscience, and genetics have provided considerable explanations and solutions to some of the most intractable mental-health problems. But researchers are increasingly relying on investigations of the immune system to identify factors that can undermine and impair mental health. Cellular extensions of the immune apparatus that reside in the brain (e.g., microglial cells) are involved in brain pathology and loss of function; this activation of microglia results in neuroinflammation and in other alterations in the immune system that impact mood, cognition, and pain perception. These alterations are implicated in devastating mental-health conditions such as depression, anxiety, schizophrenia, and autism-like spectrum disorders; in addition, degenerative disorders of the brain such as Parkinson’s and Alzheimer’s-like dementia have effects similar to those of various mental disorders because of their destruction of memory, personality, and movement.
The Immune System and Mental Health is the first book to fully investigate how immune-related cellular, molecular, and anatomical changes impact mental functioning. It combines coverage of human and animal studies to reveal immunological changes related to mental-health problems across the lifespan. It also covers the relative new research related to how the microbial composition of the gut - the microbiome - influences brain function and mental health, and discusses common comorbidities with mental illness and the inherent immunological or inflammatory component of these comorbidities that may contribute to disruptions in mental function. Written by two leaders in the field, The Immune System and Mental Health synthesizes basic and clinical research to provide a thorough understanding of the role of the immunity in neuropsychiatry.
- Considers both basic human and animal studies that address immunological changes related to mental health problems across the lifespan
- Incorporates techniques, concepts, and ideas from a variety of social, behavioral, and life sciences
- Explores the relatively new area of the microbiome, and how the microbial composition of the gut influences brain function and mental health
Advanced students and researchers in neuroscience, neuroimmunology, neuropsychiatry, neuropsychology, the behavioral and social sciences, and immunology
1. Multiple Neural and Endocrine Pathways Linked to Immune Functioning
2. The Immune System: Host Defense Against the Microbiological World
3. Lifestyle Factors Affecting Immune Functioning
4. Impact of Stressors on Non-Immune Biological Systems
5. Stress and Immunity
7. Anxiety Disorders and Posttraumatic Disorder
8. Depression and its Comorbidities
9. Autism-Spectrum Disorders
11. Neurodegenerative Disorders
- No. of pages:
- © Academic Press 2019
- 1st September 2018
- Academic Press
- Paperback ISBN:
Hymie Anisman is a Professor in the Department of Neuroscience at Carleton University, Ottawa, and also holds an adjunct appointment with the Institute of Mental Health Research (Royal Ottawa Hospital). Professor Anisman has been a Senior Ontario Mental Health Research Fellow, is a Fellow of the Royal Society of Canada, and has held a Canada Research Chair in Neuroscience since 2001. The principal theme of his research is the influence of stressors on neurochemical, neuroendocrine, and immune systems, and how these stressors influence psychological and physical (immune-related and neurodegenerative) disorders. His work has spanned studies using animal models to assess stress-related pathology as well as studies in humans to assess stress, coping, and appraisal processes. In addition to sitting on the editorial boards of several journals and on numerous grant panels, Professor Anisman has published more than 350 peer-reviewed journal papers, 40 book chapters, and several review papers within neuroscience and psychology journals; he has also published two authored textbooks, two edited books, and one trade book.
Canada Research Chair in Behavioral Neuroscience, Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada
Alexander Kusnecov is a Professor of Psychology at Rutgers University. His research has consistently been funded by the National Institute of Mental Health and the National Institute for Drug Abuse, and has included research into the behavioral conditioning of the immune system, the effects of stress on immune function, and, at present, the effects of T-cell activation on central nervous system functions and behavior, as well as the effects of maternal immune activation with staphylococcal enterotoxins on neurobehavioral development in offspring. He has published more than 70 peer-reviewed articles in high profile journals such as Brain, Behavior and Immunity; Neuropsychopharmacology; Nature Medicine; Nature Neuroscience; and Journal of Neuroscience, and he coedited The Wiley-Blackwell Handbook of Psychoneuroimmunology (2013) with Hymie Anisman.
Professor and Vice Chair for Undergraduate Studies, Program for Behavioral and Systems Neuroscience, Department of Psychology, Rutgers University, Piscataway, New Jersey, USA
My research is focused upon how interactions between the brain and immune system may influence the development of psychiatric and neurological conditions. In particular, how stressors impact upon neuro-immune communication to promote emotional and behavioural disturbances. Current projects are also exploring how environmental factors and immune insults may cause brain inflammation that contributes to neurodegeneration.
Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada