The Hypertensive Vascular Crisis

The Hypertensive Vascular Crisis

An Experimental Study

1st Edition - January 1, 1969

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  • Author: F. B. Byrom
  • eBook ISBN: 9781483163482

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The Hypertensive Vascular Crisis: An Experimental Study focuses on the crisis in man and of the hypertension from which it originates and the development of an experimental model and its use to obtain information to suggest a working hypothesis. The publication first offers information on the clinical problem and experimental evidence. Discussions focus on hypertension, essential and malignant hypertension, vicious circle in chronic hypertension, effect of pregnancy on experimental hypertension, and reversibility of chronic hypertension. The text then examines the hypothesis tested, including changes in vascular caliber re-examined, possible effects of the changes in caliber, structural lesions re-examined, focal edema re-examined, and thesis restated. The manuscript elaborates on technique, as well as anesthesia, resuscitation, blood pressure, apparatus, measuring systolic blood pressure, and cranial windows. The publication is a dependable source of information for readers interested in hypertensive vascular crisis.

Table of Contents

  • Preface

    Part 1 The Clinical Problem


    The Hypertension

    Hypertension and the Kidney

    Essential Hypertension

    Renal Hypertension

    Malignant Hypertension

    The vascular Crisis

    The Symptoms of the Crisis

    The Cause of the Symptoms

    Part II The Experimental Evidence

    Goldblatt's Experiment

    Unilateral Renal Hypertension in the Rat

    Changes in the 'Clipped' Kidney

    Changes in the Untouched Opposite Kidney

    The Vicious Circle in Chronic Hypertension

    The Effect of Pregnancy on Experimental Hypertension

    The Reversibility of Chronic Hypertension

    The Vascular Crisis in Experimental Hypertension

    The 'Clinical' Picture

    The Effect of Treatment

    Aggravating Factors

    The Pathogenesis of the Crisis

    Structural Lesions

    Cerebral Edema

    The Nature and Distribution of the Cerebral Edema

    Edema in Other Tissues

    The Caliber of the Cerebral Arteries

    The Working Hypothesis Stated

    Part III The Hypothesis Tested

    The Changes in Vascular Caliber Re-Examined

    The Intestinal Arteries

    The Retinal Arterioles

    The Cerebral Arteries Re-Examined

    The Cause of the Changes in Arterial Caliber

    The Possible Effect of the Changes in Caliber

    Excessive Dilatation

    Excessive Constriction

    The Structural Lesions Re-Examined

    The Causation of Arterial Necrosis

    Are the Lesions Caused by the Hypertension?

    'Atypical' Arterial Necrosis

    Causes of 'Atypical' Arterial Necrosis

    The Significance of 'Atypical' Arterial Necrosis

    'Atypical' Arterial Necrosis in Cerebral Crises

    'Atypical' Arterial Necrosis in Early Goldblatt Hypertension

    How Does Hypertension Cause Arterial Necrosis?

    Excessive Constriction

    Excessive Dilatation

    The Vulnerability of Weakened Arteries

    The Protective Effect of Medial Hypertrophy

    The 'Sensitizing' Effect of X Irradiation

    Extrusion of Plasma

    Giese's Experiments

    Are Other Factors Concerned in Causing Necrosis?


    'Spontaneous' Vascular Disease

    Enzyme Factors

    Vasculo-Toxic and 'Permeability' Factors



    The Causation of Associated Lesions

    Endarteritis fibrosa

    Capillary Glomerular Aneurysms and Focal Necroses

    The Effects of Hypertensive Arterial Lesions

    The Focal Edema Re-Examined

    The Cause of Focal Edema

    Is High Pressure the Cause of the Edema ?

    How does High Pressure Cause the Edema ?

    Are Other Factors Concerned?

    'Permeability' Factors

    Permeability Factors in Renal Extracts

    Ligature of Renal Arteries

    Ligature of Ureters

    Constriction of Renal Arteries

    Saline Loading

    Renin and the 'Permeability' Factor

    'Permeability' Changes in Unilateral Renal Hypertension

    High Blood Pressure as the 'Permeability' Factor

    The Effects of Hypertensive Focal Edema

    The Weaknesses of the Working Hypothesis

    The Thesis Restated


Product details

  • No. of pages: 144
  • Language: English
  • Copyright: © Butterworth-Heinemann 1969
  • Published: January 1, 1969
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483163482

About the Author

F. B. Byrom

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