The Human Hypothalamus

The Human Hypothalamus

Neuropsychiatric Disorders

1st Edition - July 7, 2021

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  • Editors: Dick Swaab, Ruud Buijs, Felix Kreier, Paul J. Lucassen, Ahmad Salehi
  • eBook ISBN: 9780128199749
  • Hardcover ISBN: 9780128199732

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The Human Hypothalamus: Neuropsychiatric Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume identifies the neurobiology and neurophysiology of disorders relating to the hypothalamus and provides treatment information for these disorders. Disorders covered include neuropsychiatric, neurodegenerative, periodic, and autoimmune disorders. Coverage includes Alzheimer’s, Parkinson’s, epilepsy, sleep, pain, depression, anxiety, OCD, PTSD, schizophrenia, autism, aggressions, addiction, and more.

Key Features

  • Summarizes research on how the hypothalamus relates to neurological disorders
  • Contains neuropsychiatric, neurodegenerative, periodic and autonomic disorders
  • Includes the neurobiology of, and treatment for, each disorder
  • Covers depression, anxiety, OCD, PTSD, schizophrenia, autism, aggression, addiction, and more
  • Provides coverage of sleep and pain


Clinical neurologists, researchers in neurology

Table of Contents

  • 1. Introduction: The human hypothalamus and neuropsychiatric disorders 
    SECTION 21  Trauma and iatrogenic disorders
    2. Chronic traumatic encephalopathy and the nucleus basalis of Meynert 
    SECTION 22  Neurobehavioral disorders
    3. Hypothalamic stress systems in mood disorders 
    4. Light therapy for mood disorders 
    5. Neurobiology of peripartum mental illness 
    6. The hypothalamo–pituitary–adrenal axis and the autonomic nervous system in burnout
    7. Posterior hypothalamus as a target in the treatment of aggression: From lesioning to deep brain stimulation
    8. The implications of hypothalamic abnormalities for schizophrenia 
    9. The promiscuity of the oxytocin–vasopressin systems and their involvement in autism
    spectrum disorder 
    SECTION 23  Epilepsy
    10. Gelastic seizures and the hypothalamic hamartoma syndrome: Epileptogenesis beyond the lesion? 
    11. The interactions between reproductive hormones and epilepsy 
    SECTION 24  Neurodegenerative disorders
    12. Alternative splicing in aging and Alzheimer's disease: Highlighting the role of tau and estrogen receptor a isoforms in the hypothalamus 
    13. Cholinergic neurodegeneration in Alzheimer disease mouse models 
    14. Autonomic disorders in Parkinson disease: Disrupted hypothalamic connectivity as revealed from resting-state functional magnetic resonance imaging
    15. Hypothalamic a-synuclein and its relation to autonomic symptoms and neuroendocrine abnormalities in Parkinson disease 
    16. Lewy bodies in the olfactory system and the hypothalamus 
    17. Hypothalamic pathology in Huntington disease 
    18. Endocrine dysfunction in adrenoleukodystrophy 
    19. Hypothalamic symptoms of frontotemporal dementia disorders
    SECTION 25  Olfactory system
    20. The vomeronasal organ: History, development, morphology, and functional neuroanatomy 
    21. Pheromone effects on the human hypothalamus in relation to sexual orientation and gender
    22. Kallmann syndrome and idiopathic hypogonadotropic hypogonadism: The role of semaphorin signaling on GnRH neurons 
    23. Olfaction as an early marker of Parkinson's disease and Alzheimer's disease 
    SECTION 26  Autonomic and sleep disorders
    24. The hypothalamus and its role in hypertension 
    25. The heart is lost without the hypothalamus
    26. Sleep disorders and the hypothalamus 
    SECTION 27  Addiction and pain
    27. Molecular genetics of neurotransmitters and neuropeptides involved in Internet use disorders including first insights on a potential role of hypothalamus’ oxytocin hormone 
    28. The neurobiology of cluster headache 
    SECTION 28  Critical care and brain-death
    29. Endocrine interventions in the intensive care unit 
    30. Hypothalamic function in patients diagnosed as brain dead  its practical consequences

Product details

  • No. of pages: 516
  • Language: English
  • Copyright: © Elsevier 2022
  • Published: July 7, 2021
  • Imprint: Elsevier
  • eBook ISBN: 9780128199749
  • Hardcover ISBN: 9780128199732

About the Editors

Dick Swaab

Dick Swaab (1944) earned his medical and doctoral degrees at the University of Amsterdam, where he became involved in brain research during his third year of medical school. He was Director of the Netherlands Institute for Brain Research from 1978 to 2005. Since 1979 he is Professor of Neurobiology at the Medical Faculty, University of Amsterdam.

In 1985, Dr. Swaab founded the Netherlands Brain Bank (NBB) to serve as a source of clinically and neuropathologically well-documented research tissue. Since its founding, the Brain Bank has provided samples from more than 4,000 autopsies to 500 research groups in 25 countries. He was director of the NBB until 2005.

He is Leader Research team Neuropsychiatric Disorders, Neth. Inst for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences (KNAW). Swaab is also appointed for 2011-2017 Chao Kuang Piu Chair of Zhejiang University, Hangzhou, P.R. China.

His major research interests focus on, sexual differentiation of the human brain in relation to gender identity and sexual orientation, aging of the brain, Alzheimer’s disease, the neurobiological basis of depression, suicide and eating disorders. He has published over 540 papers in SCI journals, authored more than 200 chapters in books, and edited more than 60 books. Swaab mentored 84 PhD students from which 16 are now full professor. He is “Companion in the Order of the Dutch Lion”, bestowed by her Royal Majesty Queen Beatrix of the Netherlands. In 2008 Swaab obtained the Academy medal for his role in national and international neuroscience.

Dick Swaab is author of the 2 volume monograph The Human Hypothalamus that appeared in the Handbook of Clinical Neurology series, Elsevier, Amsterdam (1000 pp) and the Dutch best seller We are our Brains (450.000 copies sold), that is translated in 14 languages. A children's version of the book (You are your brains) has also appeared in Dutch in 2013 and Russian (2014). Swaab's H-factor is 76.

Affiliations and Expertise

Netherlands Institute for Brain Research, University of Amsterdam, Amsterdam, The Netherlands

Ruud Buijs

Dr. Ruud M. Buijs is head of the Physiology department of the I.I.Biomedicas at the UNAM university and leader of the group Hypothalamic Integration Mechanisms. In that group, the scientists study how the brain and body interact with each other, and hereby the attention is focussed on autonomic and hormonal regulation of body functions under the influence of the biological clock of the brain.

Affiliations and Expertise

Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico D.F.

Felix Kreier

Felix Kreier is a pediatrician and affiliated with OLVG Hospitals in Amsterdam, The Netherlands.

Affiliations and Expertise

OLVG Hospitals, Amsterdam, The Netherlands

Paul J. Lucassen

Paul J. Lucassen did his PhD in 1995 on Alzheimer’s Disease at the Netherlands Institute for Brain Research in Amsterdam. After a.o. a postdoc in Leiden, he became Full Professor of Brain Plasticity in 2011 at the Swammerdam Institute for Life Sciences (SILS) of the University of Amsterdam, The Netherlands. His group studies molecular, nutritional, pharmacological and environmental regulation of brain plasticity. They combine molecular tools, in vitro/vivo model systems, human brain tissue, cohort studies and brain imaging. A major focus is on adult neurogenesis and cognition in relation to; (early life) stress, exercise, enrichment, depression, brain insults and dementia.

Affiliations and Expertise

Swammerdam Institute for Life Sciences (SILS) - Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands

Ahmad Salehi

Ahmad Salehi is affiliated with Stanford Medical School, Department of Psychiatry & Behavioral Sciences, in Palo Alto, CA, United States.

Affiliations and Expertise

Stanford Medical School, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA, United States

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