The Human Genome

The Human Genome

A User's Guide

1st Edition - September 23, 1998

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  • Authors: R. Scott Hawley, Catherine Mori
  • eBook ISBN: 9780080518855

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Description

The Human Genome: A User's Guide provides a concise discussion of contemporary and relevant topics in human genetics. It begins coverage of the fundamental concepts of genetics and heredity, then illustrates these concepts as they relate to the development of human sexual differentiation and sexuality. The book describes the role of the X and Y chromosomes, the role of hormone-controlled differential gene expression in sex determination, and the role of genetics in sexual orientation and sex-role development. The Human Genome discusses the interface between science and society, covering the basic intellectual processes that underlie genetic analysis and gene therapy. It also looks at the use of cloning techniques to search for genes responsible for such human disease states as cystic fibrosis, cancer, AIDS, and mental illness. Written in an inviting and engaging style, The Human Genome meets the interests and answers the questions of today's students.

Key Features

@introbul:Key Features:
@bul:* Offers a concise discussion of contemporary human genetics and relevant topics
* Accessible to the reader with no formal science background
* Reviews the fundamental principles that und

Readership

Lower-division undergraduate students in courses in genetics, human genetics, and molecular biology; medical students; non-majors taking genetics or human genetics courses.

Table of Contents

  • THE BASICS OF HEREDITY
    The Answer in a Nut Shell: Genes, Proteins, and the Meaning of Life
    Mendel and the Concept of the Gene.
    How Genes Work: The Story of How Genes Encode Proteins or "The Central Dogma of Molecular Biology"
    How Genes Move: Chromosomes and the Physical Basis of the Laws of Mendel
    Absent Essentials and Monkey Wrenches: How Mutations Produce a Phenotype

    HOW GENES DETERMINE OUR SEX
    Sex and Chromosomes, Sex and Hormones, Sex and...
    Sex Causes Problems: The Inactivation of the Second X Chromosome
    Gender Identity and Sexual Orientation


    WHEN MEIOSIS OR MENDELIAN INHERITANCE FAILS
    Failed Chromosome Segregation and the Etiology of Down's Syndrome
    Extreme Mutation: Triplet Repeat Syndromes
    Imprinting or Epigenetic Changes in Genes and Chromosomes


    HUMAN GENES
    Introduction to Gene Cloning
    DNA Polymorphisms as Genetic Markers in Humans (and the Miracle of PCR)
    Human Gene Mapping: A General Approach
    Cystic Fibrosis
    Mammoth Genes: Muscular Dystrophy and Neurofibromatosis
    Genes and Cancer


    INTERACTIONS OF GENES AND THE ENVIRONMENT
    Multifactorial Inheritance: Towards Finding the Genes for Manic Depression and Schizophrenia
    The Monoamine Oxidose A Gene and a Genetic Basis for Criminality?
    Genetics of the Human AIDS Virus.


    PRENATAL DIAGNOSIS
    Methods of Prenatal Diagnosis
    Potential for Gene Therapy


    EPILOGUE: FEARS, FAITH AND FANTASIES

Product details

  • No. of pages: 413
  • Language: English
  • Copyright: © Academic Press 1998
  • Published: September 23, 1998
  • Imprint: Academic Press
  • eBook ISBN: 9780080518855

About the Authors

R. Scott Hawley

R. Scott Hawley (PhD, Genetics, University of Washington) is an American Cancer Society Research Professor and Investigator at the Stowers Institute for Medical Research. He has served as President of the Genetics Society of America in 2010 and in 2008 he received that society's Elizabeth W. Jones Award for Excellence in Teaching. He widely known for his teaching, for his research on meiosis and for the authorship of numerous textbooks and research papers.

Affiliations and Expertise

Stowers Institute for Medical Research, Kansas City, MO

Catherine Mori

Catherine Mori is an accomplished health education writer. Her previous writing has concentrated on drug- and alcohol-related risks to health and on the treatment and prevention of drug and alcohol addiction. Her interest in human genetics began when she attended Dr. Hawley's Human Genetics course for non-majors at UC Davis. She has worked extensively as a management consultant in the private sector and is currently working at IBM Global Services in Mountain View, California.

Affiliations and Expertise

IBM Global Services, Mountain View, California

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