Description

Over the past few years there have been considerable advances in our understanding of cellular control mechanisms, and current research is now linking areas of biology that were previously thought of as being quite separate. Molecular Aspects of Cellular Regulation is a series of occasional books on multidisciplinary topics which illustrate general principles of cellular regulation. Previous volumes described Recently Discovered Systems of Enzyme Regulation by Reversible Phosphorylation (Volumes 1 and 3), The Molecular Actions of Toxins and Viruses (Volume 2), Molecular Mechanisms of Transmembrane Signalling (Volume 4) and Calmodulin (Volume 5). This sixth volume, The Hormonal Control of Gene Transcription, has now been published to highlight recent important advances in our understanding of this topic which is linking two of the most active areas of current biochemical and molecular biological research (hormone action and gene transcription) and leading to the emergence of unifying concepts.

Table of Contents

Section I: Introduction. Chapter 1. An overview of transcription (N. Heintz and C. Desplan). Chapter 2. Regulation of eukaryotic RNA polymerase II transcription by sequence-specific DNA binding proteins (W. Herr). Chapter 3. An overview of signal transduction (P. Parker). Chapter 4. Hormonal effects on gene suppression mediated through trans-acting factors and chromatin structure (I.H. Williams and J.D. Haley). Section II: Regulation by second messenger systems. Chapter 5. Characteristics of the cAMP response unit (M.R. Montminy, G.A. Gonzales and K.K. Yamamoto). Chapter 6. Urokinase-type plasminogen activator gene regulation as a model system for studying transcriptional activation by the cAMP-dependent protein kinase pathway (Y. Nagamine, M.S. Altus, J.-I. Nakagawa, D. Pearson, D. von der Ahe). Chapter 7. Probing cAMP regulated gene expression with a recombinant protein kinase inhibitor (J.R. Grove and J. Avruch). Chapter 8. The AP-1 complex and its role in transcriptional control by protein kinase C (M. Karin). Chapter 9. Hormonal and liver-specific control of expression of the tyrosine aminotransferase gene (D. Nitsch, S. Ruppert, G. Kelsey et al.). Section III: Regulation of transcription by polypeptide hormones. Chapter 10. Genes induced by serum growth factors (L.F. Lau and D. Nathans). Chapter 11. Model systems of transcriptional regulation (T. Curran). Chapter 12. Regulation of transcription by insulin (D.K. Granner and R.M. O'Brien). Chapter 13. Regulation of transcription by transforming growth factor-&bgr; (D.R. Edwards and J. Heath). Chapter 14. Transcriptional regulation of interferon-inducible genes (G. Sen). Section IV: Regulation by hormone receptor-DNA binding proteins: the steroid-superfamily. Chapter 15. Mechanisms of regulation of gene transcription by steroid receptors (M.-J.-Tsai and B. O'Malley). Chapter 16. Regulation of transcription of glucocorticoids (M. Beato, U. Brugge

Details

No. of pages:
516
Language:
English
Copyright:
© 1991
Published:
Imprint:
Elsevier Science
Print ISBN:
9780444813824
Electronic ISBN:
9780444599810

Reviews

@qu:..I was impressed by this book: it successfully combines signal transduction with transcription and it explains fundamental principles, which will not become rapidly outdated." @source:TRENDS IN GENETICS @qu:I warmly recommend it to readers, from graduate students to senior investigators, interested in the broader issues of the molecular biology of cellular regulation. @source:TRENDS IN CELL BIOLOGY @qu:The whole book has a very well equilibrated composition with regard to the ratio of the review chapters and the description of the experimemntal result of the authors. @source:BIOLOGIA PLANTARUM