The HLA FactsBook presents up-to-date and comprehensive information on the HLA genes in a manner that is accessible to both beginner and expert alike. The focus of the book is on the polymorphic HLA genes (HLA-A, B, C, DP, DQ, and DR) that are typed for in clinical HLA laboratories. Each gene has a dedicated section in which individual entries describe the structure, functions, and population distribution of groups of related allotypes. Fourteen introductory chapters provide a beginner's guide to the basic structure, function, and genetics of the HLA genes, as well as to the nomenclature and methods used for HLA typing. This book will be an invaluable reference for researchers studying the human immune response, for clinicians and laboratory personnel involved in clinical and forensic HLA typing, and for human geneticists, population biologists, and evolutionary biologists interested in HLA genes as markers of human diversity.
Introductory chapters provide good general overview of HLA field for novice immunologists and geneticists
Up-to-date, complete listing of HLA alleles
Invaluable reference resource for immunologists, geneticists, and cell biologists
Combines both structural and functional information, which has never been compiled in a single reference book previously
Serological specificity of allotypes
Identity of material sequenced including ethnic origin
Database accession numbers
Peptide binding specificities
T cell epitopes
Amino acid sequences of allotypes
Researchers and research clinicians in immunology, immunohematology, genetics, cell and molecular biology, transplantation medicine, autoimmunity, and biochemistry; researchers working in tissue typing laboratories, cancer biology, developmental biology, and researchers involved in genome mapping and sequencing; rheumatologists, endocrinologists, and physicians working on HLA-associated diseases; pharmaceutical industries working on HLA antibodies and kits.
Table of Contents
Preface. Abbreviations. The Introductory Chapters: Introduction. Human Leukocyte Antigens (HLA) Determine Histocompatibility in Transplantation. The Organisation of HLA Genes Within the HLA Complex. HLA Class I Antigens and Alleles: Workshops and Nomenclature. HLA Class II Antigens and Alleles: Workshops and Nomenclature. HLA Typing at the DNA Level. HLA Class I and II Molecules Present Peptide Antigens to Different Types of T Cell. HLA Class I Molecules Control Natural Killer Cell Function. Three-Dimensional Structures of HLA Class I Molecules. Three-Dimensional Structures of HLA Class II Molecules. HLA Polymorphism, Peptide Binding Motifs and T-Cell Epitopes. Evolution and Anthropology of HLA. HLA and Disease. Alloreactions in Transplantation. The HLA Class I and Class II Loci.
Dr. Parham was born in London and read natural sciences at Cambridge University. He began study of the genetic basis of HLA polymorphism in 1973 and has continued this line of research ever since. Dr. Parham is currently Professor of structural biology and microbiology and immunology at Stanfor University.
Affiliations and Expertise
Stanford University School of Medicine, Palo Alto, California, U.S.A.
Linda Barber's doctoral and post-doctoral studies examined the structure and function of MHC classI and classII molecules with emphasis on the impact of polymorphism on peptides bound and presented for immune surveillance. Dr. Barber's current interests focus on utilizing our understanding of the role of MHC molecules in T cell and NK cell function to develop improved prophylatic and therapeutic strategies for manipulating immune responses.