The Herpesviruses

The Herpesviruses

1st Edition - January 1, 1973

Write a review

  • Editor: Albert Kaplan
  • eBook ISBN: 9780323142663

Purchase options

Purchase options
DRM-free (PDF)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


The Herpesviruses provides information pertinent to all the herpesviruses, with emphasis on the classification, morphology, replication, physical–chemical properties, and immunological relationships of all the herpesviruses. This book presents the fundamental and clinical aspects of the viruses. Organized into 21 chapters, this book starts with an overview of the classification of the herpesvirus and proceeds to explore the origins and phylogeny of the herpesviruses. This text then examines the earliest electron microscopic studies on the morphology of the herpesviruses by using shadowcast preparations of herpes simplex virus and of herpes zoster virus. Other chapters consider the serological tests as well as the antigenic relationships among herpesviruses. The final chapter deals with the clinical application of antiviral drug treatment. This book is a valuable resource for virologists, molecular biologists, veterinarians, physicians, as well as teachers and graduate students who are interested in the herpesviruses from either a fundamental or clinical viewpoint.

Table of Contents

  • List of Contributors


    Chapter 1 Herpes: History and Classification

    I. Introduction

    II. Development of the Concept of the Herpes Group of Viruses, 500 B.C. to 1972 A.D.

    III. Subclassification of the Herpesviruses

    IV. Summary and Conclusions


    Chapter 2 Morphology

    I. Introduction

    II. Morphology of Particles of Herpes Simplex Virus

    III. Other Herpesviruses

    IV. Morphology and Clinical Diagnosis

    V. Morphology and Classification of Herpesviruses


    Chapter 3 The Physical and Chemical Properties of the Herpesviruses

    1. Introduction

    II. The Herpes Virion—Physical Properties

    III. The Herpes Virion—Chemical Properties

    IV. Resistance of the Herpesviruses to Inactivation

    V. Conclusion


    Chapter 4 Replication—Biological Aspects

    I. Introduction

    II. Host Range

    III. Environmental Factors Affecting Virus Growth

    IV. Virus Growth Cycle

    V. Cytopathogenic Effect and Quantitation of Virus Growth

    VI. Variation and Genetics


    Chapter 5 Replication of the Viruses—Morphological Aspects

    I. Introduction

    II. Attachment and Penetration

    III. Growth of the Virus

    IV. Conclusion


    Chapter 6 Replication—Biochemical Aspects

    I. Introduction

    II. Effect of Infection on Macromolecular Synthesis

    III. RNA Synthesis

    IV. DNA Synthesis

    V. Protein Synthesis

    VI. Membrane Alterations

    VII. Virion Assembly

    VIII. Abortive Infection

    IX. Enzymology of the Infected Cells

    X. Control of the Infective Process


    Chapter 7 Immunological Relationships

    I. Serological Tests

    II. Immunology of Herpesviruses


    Chapter 8 Interference and Interferon with Respect to Herpesviruses

    I. Introduction

    II. Interference—Possibly Mediated by Interferon

    III. Interference Not Mediated by Interferon

    IV. Relative Resistance of Herpesviruses to Interferon and Poly rI:Poly rC

    V. Induction of Interferon

    VI. Dual Infections

    VII. Conclusion


    Chapter 9 Persistent and Latent Infections

    I. Introduction and Definition of Terms

    II. In Vivo Studies

    III. Latency In Vitro

    IV. Transformation of Cells In Vitro

    V. Recapitulation


    Chapter 10 Herpes Simplex Virus

    I. Introduction

    II. Pathology and Pathogenesis

    III. Epidemiology

    IV. Immunity to Herpesvirus

    V. Clinical Manifestations of Herpesvirus Type 1

    VI. Clinical Manifestations of Herpesvirus Type 2

    VII. Herpesvirus Type 2 and Cervical Cancer

    VIII. Laboratory Diagnosis

    IX. Conclusion


    Chapter 11 Varicella—Zoster Viruses

    I. Introduction

    II. Clinical Features and Diagnosis

    III. Pathology and Pathogenesis

    IV. Immunity

    V. Epidemiology


    Chapter 12 Cytomegaloviruses

    I. Introduction

    II. Disease States Associated with CMV (Essential Clinical Features)

    III. CMV in Animals

    IV. Pathogenesis and Pathology

    V. Immunity

    VI. Epidemiology

    VII. Treatment, Prevention, and Control

    VIII. Summary


    Chapter 13 The Simian Herpesviruses

    I. Introduction

    II. Introduction to and Origin of the Simian Herpesviruses

    III. Nature of Infections Produced

    IV. Distribution and Prevalence

    V. Epidemiological Features

    VI. Diagnosis of Simian Infections

    VII. Prevention and Control

    VIII. Simian Herpesviruses as Zoonotic Agents

    IX. Epidemiologic Features of H. simiae Infection in Man

    X. Pathogenesis in Man

    XI. Clinical Features

    XII. Clinical and Laboratory Diagnosis

    XIII. Preventive Measures


    Chapter 14 Viruses of Other Vertebrates

    I. Introduction

    II. Bovine Herpesvirus-1 Infections: Infectious Bovine Rhinotracheitis, Infectious Pustular Vulvovaginitis

    III. Bovine Herpesvirus-2 Infection: Bovine Herpesvirus Mammillitis

    IV. Equine Herpesvirus Infections: Equine Rhinopneumonitis, Equine Coital Exanthema

    V. Porcine Herpesvirus Infection: Pseudorabies

    VI. Canine Herpesvirus Infection

    VII. Feline Herpesvirus Infection: Feline Viral Rhinotracheitis

    VIII. Cottontail Herpesvirus Infection

    IX. Herpesvirus Infection of Chickens: Infectious Laryngotracheitis


    Chapter 15 Herpesviruses of Lower Vertebrates

    I. Introduction

    II. Reptilian Hosts

    III. Teleostean Fish Hosts

    IV. Specific Pathogen-Free Test Animals


    Chapter 16 The Epstein-Barr Virus

    I. History

    II. Virus-Cell Relationships

    III. EB Virus and Infectious Mononucleosis

    IV. Relationship between EB Virus and Burkitt's Lymphoma (BL)

    V. Relationship between EB Virus and other Lymphoproliferative Diseases

    VI. Relationship between EB Virus and Nasopharyngeal Carcinoma

    VII. Cell-Mediated Immunity

    VIII. Discussion


    Chapter 17 Marek's Disease

    I. Introduction

    II. Clinical Disease

    III. Pathology

    IV. Etiology

    V. Virology

    VI. Epizootiology

    VII. Control


    Chapter 18 Herpesvirus saimiri

    I. Introduction

    II. Studies in Vitro

    III. Natural History

    IV. Pathogenesis of Diseases Caused by Herpesvirus saimiri

    V. Discussion

    VI. Addendum


    Chapter 19 The Lucké Renal Carcinoma of the Frog

    I. Introduction

    II. The Tumor

    III. Properties of the Lucké Tumor-Associated Herpesvirus


    Chapter 20 Chemotherapy—Molecular Aspects

    I. 5-Iodo-2'-Deoxyuridine (IUdR, IdUrd, IdU, Idoxuridine)

    II. 6-Azauracil Ribonucleoside (6-Azauridine)

    III. 5-Ethyl-2'-Deoxyuridine

    IV. Trifluoromethyl-2'-Deoxyuridine

    V. 1-ß-D-Arabinofuranosyl Cytosine (Arabinosyl Cytosine, Cytosine Arabinoside)

    VI. 9-ß-D-Arabinofuranosyl Adenine (Adenine Arabinoside)

    VII. Conclusion


    Chapter 21 Chemotherapy of Herpesviruses—Clinical Aspects

    I. Introduction

    II. Antiviral Chemotherapy in Experimental Herpes Infections of Laboratory Animals

    III. Herpetic (HSV) Keratitis in Man

    IV. Herpesvirus Infections with Prominent Skin Lesions (Simplex, Zoster, Varicella)

    V. Herpesvirus Encephalitis

    VI. Conclusions


    Author Index

    Subject Index

Product details

  • No. of pages: 756
  • Language: English
  • Copyright: © Academic Press 1973
  • Published: January 1, 1973
  • Imprint: Academic Press
  • eBook ISBN: 9780323142663

About the Editor

Albert Kaplan

Ratings and Reviews

Write a review

There are currently no reviews for "The Herpesviruses"