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The Herpesviruses - 1st Edition - ISBN: 9780123970503, 9780323142663

The Herpesviruses

1st Edition

Editor: Albert Kaplan
eBook ISBN: 9780323142663
Imprint: Academic Press
Published Date: 1st January 1973
Page Count: 756
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The Herpesviruses provides information pertinent to all the herpesviruses, with emphasis on the classification, morphology, replication, physical–chemical properties, and immunological relationships of all the herpesviruses. This book presents the fundamental and clinical aspects of the viruses.
Organized into 21 chapters, this book starts with an overview of the classification of the herpesvirus and proceeds to explore the origins and phylogeny of the herpesviruses. This text then examines the earliest electron microscopic studies on the morphology of the herpesviruses by using shadowcast preparations of herpes simplex virus and of herpes zoster virus. Other chapters consider the serological tests as well as the antigenic relationships among herpesviruses. The final chapter deals with the clinical application of antiviral drug treatment. This book is a valuable resource for virologists, molecular biologists, veterinarians, physicians, as well as teachers and graduate students who are interested in the herpesviruses from either a fundamental or clinical viewpoint.

Table of Contents

List of Contributors


Chapter 1 Herpes: History and Classification

I. Introduction

II. Development of the Concept of the Herpes Group of Viruses, 500 B.C. to 1972 A.D.

III. Subclassification of the Herpesviruses

IV. Summary and Conclusions


Chapter 2 Morphology

I. Introduction

II. Morphology of Particles of Herpes Simplex Virus

III. Other Herpesviruses

IV. Morphology and Clinical Diagnosis

V. Morphology and Classification of Herpesviruses


Chapter 3 The Physical and Chemical Properties of the Herpesviruses

1. Introduction

II. The Herpes Virion—Physical Properties

III. The Herpes Virion—Chemical Properties

IV. Resistance of the Herpesviruses to Inactivation

V. Conclusion


Chapter 4 Replication—Biological Aspects

I. Introduction

II. Host Range

III. Environmental Factors Affecting Virus Growth

IV. Virus Growth Cycle

V. Cytopathogenic Effect and Quantitation of Virus Growth

VI. Variation and Genetics


Chapter 5 Replication of the Viruses—Morphological Aspects

I. Introduction

II. Attachment and Penetration

III. Growth of the Virus

IV. Conclusion


Chapter 6 Replication—Biochemical Aspects

I. Introduction

II. Effect of Infection on Macromolecular Synthesis

III. RNA Synthesis

IV. DNA Synthesis

V. Protein Synthesis

VI. Membrane Alterations

VII. Virion Assembly

VIII. Abortive Infection

IX. Enzymology of the Infected Cells

X. Control of the Infective Process


Chapter 7 Immunological Relationships

I. Serological Tests

II. Immunology of Herpesviruses


Chapter 8 Interference and Interferon with Respect to Herpesviruses

I. Introduction

II. Interference—Possibly Mediated by Interferon

III. Interference Not Mediated by Interferon

IV. Relative Resistance of Herpesviruses to Interferon and Poly rI:Poly rC

V. Induction of Interferon

VI. Dual Infections

VII. Conclusion


Chapter 9 Persistent and Latent Infections

I. Introduction and Definition of Terms

II. In Vivo Studies

III. Latency In Vitro

IV. Transformation of Cells In Vitro

V. Recapitulation


Chapter 10 Herpes Simplex Virus

I. Introduction

II. Pathology and Pathogenesis

III. Epidemiology

IV. Immunity to Herpesvirus

V. Clinical Manifestations of Herpesvirus Type 1

VI. Clinical Manifestations of Herpesvirus Type 2

VII. Herpesvirus Type 2 and Cervical Cancer

VIII. Laboratory Diagnosis

IX. Conclusion


Chapter 11 Varicella—Zoster Viruses

I. Introduction

II. Clinical Features and Diagnosis

III. Pathology and Pathogenesis

IV. Immunity

V. Epidemiology


Chapter 12 Cytomegaloviruses

I. Introduction

II. Disease States Associated with CMV (Essential Clinical Features)

III. CMV in Animals

IV. Pathogenesis and Pathology

V. Immunity

VI. Epidemiology

VII. Treatment, Prevention, and Control

VIII. Summary


Chapter 13 The Simian Herpesviruses

I. Introduction

II. Introduction to and Origin of the Simian Herpesviruses

III. Nature of Infections Produced

IV. Distribution and Prevalence

V. Epidemiological Features

VI. Diagnosis of Simian Infections

VII. Prevention and Control

VIII. Simian Herpesviruses as Zoonotic Agents

IX. Epidemiologic Features of H. simiae Infection in Man

X. Pathogenesis in Man

XI. Clinical Features

XII. Clinical and Laboratory Diagnosis

XIII. Preventive Measures


Chapter 14 Viruses of Other Vertebrates

I. Introduction

II. Bovine Herpesvirus-1 Infections: Infectious Bovine Rhinotracheitis, Infectious Pustular Vulvovaginitis

III. Bovine Herpesvirus-2 Infection: Bovine Herpesvirus Mammillitis

IV. Equine Herpesvirus Infections: Equine Rhinopneumonitis, Equine Coital Exanthema

V. Porcine Herpesvirus Infection: Pseudorabies

VI. Canine Herpesvirus Infection

VII. Feline Herpesvirus Infection: Feline Viral Rhinotracheitis

VIII. Cottontail Herpesvirus Infection

IX. Herpesvirus Infection of Chickens: Infectious Laryngotracheitis


Chapter 15 Herpesviruses of Lower Vertebrates

I. Introduction

II. Reptilian Hosts

III. Teleostean Fish Hosts

IV. Specific Pathogen-Free Test Animals


Chapter 16 The Epstein-Barr Virus

I. History

II. Virus-Cell Relationships

III. EB Virus and Infectious Mononucleosis

IV. Relationship between EB Virus and Burkitt's Lymphoma (BL)

V. Relationship between EB Virus and other Lymphoproliferative Diseases

VI. Relationship between EB Virus and Nasopharyngeal Carcinoma

VII. Cell-Mediated Immunity

VIII. Discussion


Chapter 17 Marek's Disease

I. Introduction

II. Clinical Disease

III. Pathology

IV. Etiology

V. Virology

VI. Epizootiology

VII. Control


Chapter 18 Herpesvirus saimiri

I. Introduction

II. Studies in Vitro

III. Natural History

IV. Pathogenesis of Diseases Caused by Herpesvirus saimiri

V. Discussion

VI. Addendum


Chapter 19 The Lucké Renal Carcinoma of the Frog

I. Introduction

II. The Tumor

III. Properties of the Lucké Tumor-Associated Herpesvirus


Chapter 20 Chemotherapy—Molecular Aspects

I. 5-Iodo-2'-Deoxyuridine (IUdR, IdUrd, IdU, Idoxuridine)

II. 6-Azauracil Ribonucleoside (6-Azauridine)

III. 5-Ethyl-2'-Deoxyuridine

IV. Trifluoromethyl-2'-Deoxyuridine

V. 1-ß-D-Arabinofuranosyl Cytosine (Arabinosyl Cytosine, Cytosine Arabinoside)

VI. 9-ß-D-Arabinofuranosyl Adenine (Adenine Arabinoside)

VII. Conclusion


Chapter 21 Chemotherapy of Herpesviruses—Clinical Aspects

I. Introduction

II. Antiviral Chemotherapy in Experimental Herpes Infections of Laboratory Animals

III. Herpetic (HSV) Keratitis in Man

IV. Herpesvirus Infections with Prominent Skin Lesions (Simplex, Zoster, Varicella)

V. Herpesvirus Encephalitis

VI. Conclusions


Author Index

Subject Index


No. of pages:
© Academic Press 1973
1st January 1973
Academic Press
eBook ISBN:

About the Editor

Albert Kaplan

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