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The Heparins: Properties and Clinical Applications brings the latest information on heparin, one of the world's most widely used drugs. The book describes the fascinating history of the discovery of this biological agent, how it was isolated and characterized, and its use for the treatment of thrombotic disorders. The structures of various heparins are illustrated, with their function as anticoagulants delineated. This comprehensive resource arms researchers and clinicians with a concise and practical source that will assist in biomedical research, medical practice, and in improving patient outcomes.
- Describes new pharmaceuticals derived from heparin that are devoid of anticoagulant activity, but still retain anti-inflammatory and anti-proliferative properties
- Discusses the development of non-anticoagulant heparins for the treatment of diseases, including asthma and cancer
- Presents the history of the discovery of this biological agent, how it was isolated and characterized, and its use for the treatment of thrombotic disorders
Hematologists, pathologists, biomedical scientists, physicians (emergency medicine, internal medicine, cardiology, and surgery), pharmacists, students of medicine and pharmacy
Part I. Historical Development and Properties
1. Anticoagulant Heparins
2. Non-anticoagulant Heparins
Part II. Clinical Applications
3. Prevention of Thrombosis
4. Therapy for Thrombosis
Part III. Adverse Effects
5. Bleeding, heparin-induced thrombocytopenia
- No. of pages:
- © Academic Press 2020
- 13th January 2020
- Academic Press
- Paperback ISBN:
- eBook ISBN:
Dr. Green is a hematologist with 45 years of clinical & research experience and an expert on hemostasis and thrombosis. He teaches medical students, interns, residents, fellows, and practicing physicians and has organized symposia, given national and international presentations, and published extensively on bleeding and clotting disorders. His lectures to medical students on anticoagulant therapy have garnered teaching awards, and he has been a co-investigator on landmark clinical trials of heparin and low molecular weight heparin. He is the author or co-author of two dozen publications devoted to heparins, including 19 peer-reviewed research papers in major medical journals. He is also the author of two recent books, Linked by Blood: Hemophilia and AIDS, and Factor VIII and Von Willebrand Factor.
Professor of Medicine Emeritus, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
"This is a useful addition to the library of hematologists, internists, pathologists, and other clinicians who use anticoagulant therapy. It is a helpful reference for the history of drug development and clinical trials in this area of medicine. Although many textbooks of hematology and internal medicine will contain some of this information, I am not aware of another recent book with this comprehensive focus." --Doody
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