The HDL Handbook - 2nd Edition - ISBN: 9780124078673, 9780124079243

The HDL Handbook

2nd Edition

Biological Functions and Clinical Implications

Editors: Tsugikazu Komoda
eBook ISBN: 9780124079243
Hardcover ISBN: 9780124078673
Imprint: Academic Press
Published Date: 6th November 2013
Page Count: 354
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Description

The HDL Handbook: Biological Functions to Clinical Implications brings laboratory research in HDL from bench to bedside in this needed resource for researchers and clinicians studying cholesterol, lipids, epidemiology, biochemistry, molecular medicine, and pathophysiology of cardiovascular diseases. In addition, researchers and clinicians working with an aging population, corporate researchers, post-doctorates; medical students and graduate students will find this publication useful because the scope of coverage includes basic science, genetics, epidemiology, and treatment of HDL cholesterol as well as potential targets to modify HDL cholesterol.

Key Features

  • Provides bench-to-bedside coverage of HDL with thorough coverage of basic science, genetics, epidemiology, and treatment
  • Presents a complete update with six new chapters on the latest advances in HDL cholesterol research with international perspective
  • New chapters on proteomics, clinical impact of LCAT in HDL metabolism, and an in-depth discussion of potential targets to modify HDL  provide a translational reference for clinicians

Readership

The primary audience for this work is researchers and clinicians studying cholesterol, lipids, epidemiology, biochemistry, molecular biology, molecular medicine, and pathophysiology of cardiovascular diseases; researchers and clinicians working with an aging population; corporate researchers; postdocs; medical students and graduate students.

The secondary audience is allied health professionals, nurses, and researchers and clinicians studying nutrition.

Table of Contents

Preface

Contributors

Abbreviations

Chapter 1. Introduction of HDL Molecules, Past and Brief Future

Abstract

1 Introduction

2 HDL May be an Independent Predictor of CHD

3 High Levels of HDL Sometimes Cause Atherosclerosis: the Example of CETP Deficiency

4 Is HDL-C Really “Good Cholesterol”?

5 Quantitative and Qualitative Measurement of HDL-C Molecules

6 Conclusion

References

Chapter 2. Apolipoprotein A-I Mutations and Clinical Evaluation

Abstract

1 Introduction

2 Physiological Functions of apoA-I

3 Genomic and Protein Structure of apoA-I

4 ApoA-I Deficiencies with Large Deficiency, Inversion, Nonsense, or Frameshift Mutations

5 ApoA-I Missense Mutations with Low HDL-C

6 ApoA-I Mutations Related to Amyloidosis

7 Cysteine Mutants of apoA-I

8 Anti-Atherogenic apoA-I and apoA-IMilano

9 Conclusion

References

Chapter 3. The Complexity of High-Density Lipoproteins

Abstract

1 HDL and Cardiovascular Disease

2 What is HDL?

3 HDL Metabolism

4 Moderators of HDL Particle Distribution and Composition

5 HDL Structure

6 HDL Proteomics

7 HDL Functions

8 The Future of HDL Research

References

Chapter 4. Reverse Cholesterol Transport in HDL Metabolism: Modulation of Structural and Functional Features of HDL Particles

Abstract

1 Overall Mechanism of the Reverse Cholesterol Transport

2 Relationship Between HDL Structure and Function in Reverse Cholesterol Transport

3 Metabolic Disorders Associated with a Low HDL-C Phenotype and Dysfunctional HDL Particles

4 Inflammatory States Associated with Altered HDL Function in Reverse Cholesterol Transport

5 Genetic Variants Associated with Altered HDL Function in Reverse Cholesterol Transport

6 Conclusion

References

Chapter 5. Role of ATP-Binding Cassette Transporters A1 and G1 in Reverse Cholesterol Transport and Atherosclerosis

Abstract

1 Introduction

2 The Role of Reverse Cholesterol Transport in Lipid Metabolism

3 Major Pathways for Cellular Cholesterol Efflux

4 Mechanisms for Cholesterol Efflux and Generation of Nascent HDL: Role of ABCA1

5 Mechanisms for Maturation of HDL Particles and Maintenance of Circulating HDL Levels: Role of ABCA1

6 The Role of ABCG1 in Cholesterol Efflux and HDL Metabolism

7 Transcriptional Regulation of ABCA1/G1

8 Posttranscriptional/Posttranslational Regulation of ABCA1/G1

9 The Role of ABCA1/G1 in Reverse Cholesterol Transport and Atherosclerosis in Animal Models

10 The Role of ABCA1/G1 in Atherosclerosis in Humans

11 Therapeutic Strategies Against Atherosclerosis Involving RCT Modification

12 Conclusion

References

Chapter 6. Sphingolipids and HDL Metabolism

Abstract

1 Introduction

2 Plasma HDL-SM Origination

3 Sphingolipid De Novo Synthesis and HDL Metabolism

4 Plasma SM and HDL Metabolism

5 Plasma S1P and HDL Metabolism

6 Plasma Membrane Sphingolipid Levels and Cholesterol Efflux

7 Sphingolipids and Atherosclerosis

8 Conclusion

References

Chapter 7. Role of Lecithin: Cholesterol Acyltransferase in HDL Metabolism and Atherosclerosis

Abstract

1 Introduction

2 LCAT Biochemistry

3 The Role of LCAT on Reverse Cholesterol Transport

4 Familial LCAT Deficiency and Fish-Eye Disease: Clinical Signs and Symptoms

5 Animal Models Exploring the Functional Role of LCAT

6 LCAT and its Role in Atherosclerosis in Human Studies

7 LCAT-Based Therapies

8 Conclusion

References

Chapter 8. Cholesteryl Ester Transfer Protein Inhibitors: A Hope Remains

Abstract

1 Introduction

2 HDL-TG as a Key Component Determining Neutral Lipid Transfer

3 HDL Metabolism in CETP Deficiency

4 LDL Metabolism in CETP Deficiency

5 VLDL Metabolism in CETP Deficiency

6 Antioxidant Activity in CETP Deficiency

7 Difference of Lipoprotein Phenotype Between Homozygotes and Heterozygotes with CETP Deficiency

8 Source of CETP and Cholesteryl Ester Transfer (CET) Determinant

9 Drug Designs in Clinical Trials

10 Structural Difference of CETP Inhibitors in the Cavity of CETP

11 Differential Effects Among CETP Inhibitors

12 Perspective of CETP Inhibitor

13 Conclusion

References

Chapter 9. HDL Apoprotein Mimetic Peptides as Anti-Inflammatory Molecules

Abstract

Key Concepts

1 Introduction

2 apoA-I and the History of its Derived Mimetic Peptides

3 Anti-Atherogenic Effects of apoA-I Mimetic Peptides

4 Anti-Inflammatory Properties of apoA-I Mimetic Peptides With Cells in Culture

5 In Vivo Anti-Inflammatory Properties of apoA-I-Derived Mimetic Peptides

6 Hybrid and apoE Mimetics

7 Conclusion

References

Chapter 10. Oxidized High-Density Lipoprotein: Friend or Foe

Abstract

1 Introduction

2 Clinical Relevance of oxHDL to Vascular-Related Diseases

3 Structural Alterations in HDL Components by Oxidation

4 Functional Alterations in HDL by Oxidation

5 Is oxHDL Friend or Foe?

6 Conclusion

References

Chapter 11. Current Aspects of Paraoxonase-1 Research

Abstract

Key Concepts

1 Introduction

2 PON1 and Atherosclerosis

3 Dysfunctional HDL

4 PON1 and Other Inflammatory Diseases

5 PON1 and Organophosphate Toxicity

6 PON1 and Cancer

7 PON1 and Quorum Quenching

8 PON1 and Aging

9 Conclusion

References

Chapter 12. Proteomic Diversity in HDL: A Driving Force for Particle Function and Target for Therapeutic Intervention

Abstract

Key concepts

1 Introduction to HDL-Associated Proteins

2 The Proteomic Diversity of HDL

3 Proteomic Subspeciation of HDL

4 Influence of Disease on the HDL Proteome

5 HDL Proteins as Therapeutic Targets

6 Challenges of MS-Based Analyses of the HDL Proteome

7 Conclusion

References

Index

Details

No. of pages:
354
Language:
English
Copyright:
© Academic Press 2014
Published:
Imprint:
Academic Press
eBook ISBN:
9780124079243
Hardcover ISBN:
9780124078673

About the Editor

Tsugikazu Komoda

Dr. Komoda is a visiting professor at Toho University School of Medicine in Japan. He has extensive expertise with research in alkaline phosphatase, amylase, and oxidized HDL. He co-operated the intestinal alkaline phosphatase at Washington University School of Medicine in St. Louis, Missouri. He is the recipient of the Kodama Memorial Award from Japanese Society of Electrophoresis.

Affiliations and Expertise

Visiting Professor, Toho University School of Medicine, Japan

Reviews

"Editor Komoda's research handbook for physicians and medical scientists addresses in detail the biochemistry and pathophysiology of high-density lipoprotein (HDL) cholesterol. The history of HDL research is summarized in the introduction, including its labeling as "good cholesterol" and recent questions problematizing that label."--ProtoView.com, January 2014
"This is one of the best available sources for a concise yet detailed review of the enormous data on HDL mechanics, genetics, and clinical implications…a very effective and focused presentation for a complex topic…This is an outstanding work. The book is unique in that it not only updates leaders in the field on new advances in HDL research, but it also can jump start beginners in the field." Rating: 4 Stars--Doody.com, February 28, 2014