The HDL Handbook

2nd Edition

Biological Functions and Clinical Implications

Editors: Tsugikazu Komoda
Hardcover ISBN: 9780124078673
eBook ISBN: 9780124079243
Imprint: Academic Press
Published Date: 6th November 2013
Page Count: 354
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Description

The HDL Handbook: Biological Functions to Clinical Implications brings laboratory research in HDL from bench to bedside in this needed resource for researchers and clinicians studying cholesterol, lipids, epidemiology, biochemistry, molecular medicine, and pathophysiology of cardiovascular diseases. In addition, researchers and clinicians working with an aging population, corporate researchers, post-doctorates; medical students and graduate students will find this publication useful because the scope of coverage includes basic science, genetics, epidemiology, and treatment of HDL cholesterol as well as potential targets to modify HDL cholesterol.

Key Features

  • Provides bench-to-bedside coverage of HDL with thorough coverage of basic science, genetics, epidemiology, and treatment
  • Presents a complete update with six new chapters on the latest advances in HDL cholesterol research with international perspective
  • New chapters on proteomics, clinical impact of LCAT in HDL metabolism, and an in-depth discussion of potential targets to modify HDL  provide a translational reference for clinicians

Readership

The primary audience for this work is researchers and clinicians studying cholesterol, lipids, epidemiology, biochemistry, molecular biology, molecular medicine, and pathophysiology of cardiovascular diseases; researchers and clinicians working with an aging population; corporate researchers; postdocs; medical students and graduate students.

The secondary audience is allied health professionals, nurses, and researchers and clinicians studying nutrition.

Table of Contents

Preface

Contributors

Abbreviations

Chapter 1. Introduction of HDL Molecules, Past and Brief Future

Abstract

1 Introduction

2 HDL May be an Independent Predictor of CHD

3 High Levels of HDL Sometimes Cause Atherosclerosis: the Example of CETP Deficiency

4 Is HDL-C Really “Good Cholesterol”?

5 Quantitative and Qualitative Measurement of HDL-C Molecules

6 Conclusion

References

Chapter 2. Apolipoprotein A-I Mutations and Clinical Evaluation

Abstract

1 Introduction

2 Physiological Functions of apoA-I

3 Genomic and Protein Structure of apoA-I

4 ApoA-I Deficiencies with Large Deficiency, Inversion, Nonsense, or Frameshift Mutations

5 ApoA-I Missense Mutations with Low HDL-C

6 ApoA-I Mutations Related to Amyloidosis

7 Cysteine Mutants of apoA-I

8 Anti-Atherogenic apoA-I and apoA-IMilano

9 Conclusion

References

Chapter 3. The Complexity of High-Density Lipoproteins

Abstract

1 HDL and Cardiovascular Disease

2 What is HDL?

3 HDL Metabolism

4 Moderators of HDL Particle Distribution and Composition

5 HDL Structure

6 HDL Proteomics

7 HDL Functions

8 The Future of HDL Research

References

Chapter 4. Reverse Cholesterol Transport in HDL Metabolism: Modulation of Structural and Functional Features of HDL Particles

Abstract

1 Overall Mechanism of the Reverse Cholesterol Transport

2 Relationship Between HDL Structure and Function in Reverse Cholesterol Transport

3 Metabolic Disorders Associated with a Low HDL-C Phenotype and Dysfunctional HDL Particles

4 Inflammatory States Associated with Altered HDL Function in Reverse Cholesterol Transport

5 Genetic Variants Associated with Altered HDL Function in Reverse Cholesterol Transport

Details

No. of pages:
354
Language:
English
Copyright:
© Academic Press 2014
Published:
Imprint:
Academic Press
Hardcover ISBN:
9780124078673
eBook ISBN:
9780124079243
Paperback ISBN:
9780128102961

About the Editor

Tsugikazu Komoda

Dr. Komoda is a visiting professor at Toho University School of Medicine in Japan. He has extensive expertise with research in alkaline phosphatase, amylase, and oxidized HDL. He co-operated the intestinal alkaline phosphatase at Washington University School of Medicine in St. Louis, Missouri. He is the recipient of the Kodama Memorial Award from Japanese Society of Electrophoresis.

Affiliations and Expertise

Visiting Professor, Toho University School of Medicine, Japan

Reviews

"Editor Komoda's research handbook for physicians and medical scientists addresses in detail the biochemistry and pathophysiology of high-density lipoprotein (HDL) cholesterol. The history of HDL research is summarized in the introduction, including its labeling as "good cholesterol" and recent questions problematizing that label."--ProtoView.com, January 2014
"This is one of the best available sources for a concise yet detailed review of the enormous data on HDL mechanics, genetics, and clinical implications…a very effective and focused presentation for a complex topic…This is an outstanding work. The book is unique in that it not only updates leaders in the field on new advances in HDL research, but it also can jump start beginners in the field." Rating: 4 Stars--Doody.com, February 28, 2014