The Handbook of Metabolic Phenotyping - 1st Edition - ISBN: 9780128122938, 9780128122945

The Handbook of Metabolic Phenotyping

1st Edition

Editors: John Lindon Jeremy Nicholson Elaine Holmes
eBook ISBN: 9780128122945
Paperback ISBN: 9780128122938
Imprint: Elsevier
Published Date: 5th October 2018
Page Count: 619
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Description

The Handbook of Metabolic Phenotyping is the definitive work on the rapidly developing subject of metabolic phenotyping. It explores in detail the wide array of analytical chemistry and statistical modeling techniques used in the field, coupled with surveys of the various application areas in human development, nutrition, disease, therapy, and epidemiology to create a comprehensive exploration of the area of study. It covers recent studies that integrate the various -omics data sets to derive a systems biology view. It also addresses current issues on standardization, assay and statistics validation, and data storage and sharing. Written by experts with many years of practice in the field who pioneered many of the approaches widely used today, The Handbook of Metabolic Phenotyping is a valuable resource for postgrads and research scientists studying and furthering the field of metabolomics.

Key Features

  • Contains theoretical and practical explanations of all the main analytical chemistry techniques used in metabolic phenotyping
  • Explores, in detail, the many diverse statistical approaches used in the field
  • Offers practical tips for successfully conducting metabolic phenotyping studies
  • Features reviews of all of the various fields of activity relating to human studies

Readership

For postgraduate and professional research scientists working in the field of analytical chemistry, biochemistry, drug discovery and development in pharmaceutical companies, or working in related industries such as agriculture and plant biochemistry, forensic science, environmental monitoring, etc.

Table of Contents

1. An Overview of Metabolic Phenotyping and Its Role in Systems Biology

2. NMR Spectroscopy Methods in Metabolic Phenotyping

3. The Role of Ultra Performance Liquid Chromatography-Mass Spectrometry in Metabolic Phenotyping

4. GC-MS-Based Metabolic Phenotyping

5. Metabolic Phenotyping Using Capillary Electrophoresis Mass Spectrometry

6. Supercritical Fluid Chromatography for Metabolic Phenotyping: Potential and Applications

7. The iKnife: Development and Clinical Applications of Rapid Evaporative Ionization Mass Spectrometry

8. Univariate Statistical Modeling, Multiple Testing Correction, and Visualization in Metabolome-Wide Association Studies

9. Multivariate Statistical Methods for Metabolic Phenotyping

10. Data-Driven Visualizations in Metabolic Phenotyping

11. Big Data and Databases for Metabolic Phenotyping

12. Progress in Standardization of Metabolic Phenotyping Data

13. Conception, Implementation and Operation of Large-Scale Metabolic Phenotyping Centres: Phenome Centres

14. Applications of Metabolic Phenotyping in Pharmaceutical Research and Development

15. Metabolic Phenotyping in Nutrition Research

16. Metabolic Phenotyping in Clinical Practice

17. Applications of Metabolic Phenotyping in Epidemiology

18. Influence of the Human Gut Microbiome on the Metabolic Phenotype

19. Linking Metabolic Phenotyping and Genomic Information

20. Metabolic Phenotyping: History, Status, and Prospects


Details

No. of pages:
619
Language:
English
Copyright:
© Elsevier 2019
Published:
Imprint:
Elsevier
eBook ISBN:
9780128122945
Paperback ISBN:
9780128122938

About the Editor

John Lindon

John Lindon

Dr. John C. Lindon is a professor and senior research investigator in the Division of Computational and Systems Medicine, part of the Department of Surgery and Cancer, Imperial College London. He is also a founder, director of, and a consultant to Metabometrix Ltd, a company spun out of Imperial College to exploit the commercial possibilities of metabolic phenotyping. He is editor in chief of the Encyclopedia of Spectroscopy and Spectrometry and is on the editorial board of several journals. His major research interest is the use of NMR and other analytic methods coupled with multivariate statistics to study biofluids and tissues, a field now termed metabolic phenotyping.

Affiliations and Expertise

Imperial College London, London, UK

Jeremy Nicholson

Jeremy Nicholson

Dr. Jeremy K. Nicholson is the head of the Department of Surgery and Cancer at Imperial College London and has held honorary professorships at six universities. Additionally, he held two professorships at the Chinese Academy of Sciences, of which he was elected as an Albert Einstein Honorary Professor in 2014. He is also a founder, director, chief scientist, and chief scientist officer at Metabometrix Ltd. His research interests include spectroscopic and chemometric approaches to the investigation of disturbed metabolic processes in complex organisms.

Affiliations and Expertise

Imperial College London, London, UK

Elaine Holmes

Dr. Elaine Holmes is the head of the Division of Computational and Systems Medicine and a professor of chemical biology in the Department of Surgery and Cancer at Imperial College London. She has over 20 years of experience in metabonomic technology and its applications. Her focus is on the discovery and development of metabolic biomarkers of disease in personalized health-care and population studies with significant contributions to cardiovascular, neuroscience, and infectious disease research. Recently, Prof. Holmes has driven large-scale profiling efforts defining the concept of the metabolome-wide association study (MWAS) in molecular epidemiology, specifically exploring the link between hypertension, diet, and metabolic profiles.

Affiliations and Expertise

Imperial College London, London, UK

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