The Gut-Brain Axis

The Gut-Brain Axis

Dietary, Probiotic, and Prebiotic Interventions on the Microbiota

1st Edition - May 13, 2016

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  • Editors: Niall Hyland, Catherine Stanton
  • Hardcover ISBN: 9780128023044
  • eBook ISBN: 9780128025444

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The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota examines the potential for microbial manipulation as a therapeutic avenue in central nervous system disorders in which an altered microbiota has been implicated, and explores the mechanisms, sometimes common, by which the microbiota may contribute to such disorders.

Key Features

  • Focuses on specific areas in which the microbiota has been implicated in gut-brain communication
  • Examines common mechanisms and pathways by which the microbiota may influence brain and behavior
  • Identifies novel therapeutic strategies targeted toward the microbiota in the management of brain activity and behavior


Professors, Associate Professors, PostDocs, Graduate Students, and Team Leaders researching: Gut-brain axis, Neuro-Gastroenterology, Microbiology, Nutrition, Food Science, Psychiatry, Behavioral Sciences, Neuroscience, Translational Research

Table of Contents

  • 1. Global and Epidemiological Perspectives on Diet and Mood
    2. Targeting the microbiota: Considerations for developing probiotics as functional foods
    3. Food- and non-food based strategies for effective delivery of probiotics
    4. Bioactive- and non-bioactive food constituents and their influence on the microbiome
    5. Correlating the gut microbiome to health and disease
    6. The microbiome and aging: Impact on health and wellbeing
    7. Importance of the microbiota in early life and influence on future health
    8. Utility of microbial genome sequencing in probiotic strain identification: Promises and pitfalls
    9. Germ-Free Animals: A Key Tool in Unravelling How the Microbiota Affects Brain and Behavior
    10. Sensitivity of the hypothalamic-pituitary-adrenal axis to the gut microbiota: Opportunities for dietary intervention
    11. A neuroactive microbiome
    12. The influence of diet and the gut microbiota in schizophrenia
    13. Influence of the microbiota on the development and function of "the second brain" - the enteric nervous system
    14. Dietary inventions and brain-gut disorders
    15. Altering the gut microbiome for cognitive benefit?
    16. The role of the microbiota in neurodevelopmental disorders
    17. The role of the microbiota and potential for dietary intervention in chronic fatigue syndrome
    18. Potential for pre - and probiotics in managing psychological symptoms associated with alcohol-dependence
    19. Where next for dietary intetventions and the brain-gut axis?
    20. Perspectives on targeting the microbiome in developing global populations
    21. Regulatory considerations for the use and marketing of probiotics and functional foods
    22. Microbiota and Metabolism

Product details

  • No. of pages: 508
  • Language: English
  • Copyright: © Academic Press 2016
  • Published: May 13, 2016
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128023044
  • eBook ISBN: 9780128025444

About the Editors

Niall Hyland

Dr Niall Hyland is a Lecturer in Pharmacology & Therapeutics and a member of Faculty at the Alimentary Pharamabiotic Centre (APC) at University College Cork (UCC). Prior to returning to Ireland in 2007, his work on lower esophageal sphincter function, at Louisiana State University, had direct clinical implications for gastrointestinal disorders such as reflux disease. He subsequently completed his Ph.D in Pharmacology at Kings College London examining the functional role of neuropeptide Y receptors in the colon. From London, he moved to the University of Calgary in Canada, having obtained an AstraZeneca-supported Fellowship, to study the influence of obesity, inflammation and early-life immune challenge on intestinal physiology. His current research is focused on understanding the role of commensal organisms and putative probiotics on colonic fluid and electrolyte transport and the role of the innate immune system in functional bowel disorders. He has competitively obtained independent research support from the Health Research Board (Ireland), Science Foundation Ireland, through their support of the APC, and from Canadian Association of Gastroenterology-Canadian Institutes of Health Research. Niall has published in leading gastroenterology journals including Gut and Gastroenterology.

Affiliations and Expertise

Senior Lecturer, Department of Physiology, University College Cork, Cork, Ireland

Catherine Stanton

Prof. Catherine Stanton is Senior Principal Research Officer at Teagasc Moorepark Food Research Centre, Moorepark, Fermoy, Ireland, Research Professor at University College Cork, College of Medicine and Health and one of the original PI of APC Microbiome Ireland. Her research program addresses development of innovative dairy foods and probiotics that influence human health and the developing gut microbiota in early life.  She has led numerous national and international grants, including the coordination of a number EU projects on various aspects of probiotics for human and animal applications.

Affiliations and Expertise

Senior Principal Research Officer, Teagasc Moorepark Food Research Centre, Moorepark Fermoy; Research Professor, College of Medicine and Health, University College Cork, Cork, Ireland

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