The Glycoconjugates - 1st Edition - ISBN: 9780123561015, 9780323145398

The Glycoconjugates

1st Edition

Mammalian Glycoproteins and Glycolipids

eBook ISBN: 9780323145398
Imprint: Academic Press
Published Date: 1st January 1977
Page Count: 578
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The Glycoconjugates: Mammalian Glycoproteins and Glycolipids, Volume I is a collaboration of different experts in the field of molecular biology on the subject of glycoconjugates.

The text discusses the historical aspect, nomenclature, biosynthesis, and catabolism of glycoconjugates and their role in normal and pathological processes. Also covered are topics such as the purification of glycoproteins; the elucidation of the amino acid sequence of glycoproteins; the glycoproteins found in the different parts of the human body; glycoenzymes; and glycohormones.

The book is recommended for molecular biologists, organic chemists, and biochemists who would like to know more about glycolipids and glycoproteins and their applications.

Table of Contents

List of Contributors


Contents of Volume II

1 General Aspects

I. Historical

II. Nomenclature

III. The Sialic Acids

IV. Biosynthesis and Catabolism

V. Plasma Membranes and Mucopolysaccharides

VI. Role in Normal and Pathological Processes


2 Methods of Analysis and Structural Determination

Section 1 Purification of Glycoproteins and Criteria of Purity

I. Isolation and Purification of Glycoproteins

II. The Concept and Proof of Homogeneity


Section 2 Histochemistry

I. Introduction

II. Staining Methods and Their Specificity

III. Electron Microscopic Techniques

IV. Radioautography

V. Fluorescence Techniques

VI. Quantitation


Section 3 Use of Enzymes in Elucidation of Structure

I. Introduction

II. Methods and Procedures

III. Structural Studies on Glycoproteins

IV. Structural Studies on Sphingoglycolipids

V. Concluding Remarks


Section 4 Nature of Linkages between Protein Core and Oligosaccharides

I. Introduction

II. N-Acetylglucosaminylasparagine Linkage

III. N-Acetylgalactosaminylserine (-Threonine) Linkage

IV. Galactosylhydroxylysine Linkage

V. Addendum: Further Discussion of the β-Elimination Reaction (by Ward Pigman and Fred Downs)

Procedure (Downs and Pigman, 1976)


Section 5 The Elucidation of the Amino Acid Sequence of Proteins and Glycoproteins

I. Introduction

II. Considerations Preceding the Elucidation of Amino Acid Sequence

III. Elucidation of Amino Acid Sequence

IV. Determination of the Positions of Disulfide Bonds

V. Additional Aspects of the Study of the Primary Structure Pertaining Particularly to Glycoproteins

VI. Protein Variants

VII. Addendum


Section 6 Molecular Weight Determination and Physical Properties

I. Molecular Parameters

II. Methods Used for Determination of Molecular Parameters


3 Mucus Glycoproteins

Section 1 Introduction

I. Sources

II. Structure

III. Blood Group Activity

IV. Stimulatory Processes

V. Comparison of Mucus Glycoproteins


Section 2 Submandibular and Sublingual Glycoproteins

I. Characterized Products

II. Preparation

III. Polydispersity and Molecular Weight

IV. Composition of Some Purified Salivary Glycoproteins

V. Structure of Protein Core


Section 3 Human Submaxillary, Sublingual, and Parotid Glycoproteins and Enamel Pellicle

I. Introduction

II. Methods of Collection of Saliva

III. General Methods of Identification, Separation, and Characterization

IV. Glycoproteins of Submaxillary Saliva

V. Glycoproteins of Sublingual Saliva

VI. Glycoproteins of Parotid Saliva

VII. Glycoproteins of Whole Saliva

VIII. Factors Affecting Composition of Saliva

IX. Enamel Pellicles


Section 4 Blood Group Glycoproteins

I. Introduction

II. Preparation

III. Composition

IV. Oligosaccharide Composition

V. Present Status


Section 5 Gastrointestinal Glycoproteins

I. Introduction

II. Stomach

III. Bile Mucins

IV. Intestinal Mucins

V. Addendum: Histochemistry


Section 6 Respiratory Tract

I. Introduction

II. Collection, Purification, and Structure

III. Secretion

IV. Relation to Human Disease

V. Summary


Section 7 Cervical Mucus Glycoproteins

I. Functional Role of Glycoproteins in Cervical Mucus

II. Hormonal Regulation

III. Physical Properties and Structure of the Glycoproteins

IV. Mechanisms of Action of Sex Hormones

V. Purification

VI. Methods of Preparation and Purification

VII. Analysis of Purified Fractions

VIII. Pathology


4 Blood Glycoproteins

Section 1 Plasma

I. Introduction

II. Description of the Well-Characterized Plasma Glycoproteins

III. Chemical and Physicochemical Data on Well-Characterized Plasma Glycoproteins


Section 2 Immunoglobulins

I. Introduction

II. Classification of Immunoglobulins

III. The Variable Regions and the Combining Site

IV. Genetic Variation

V. The Hinge Region and Disulfide Bonding of Subunits

VI. Immunoglobulin Evolution

VII. Antibody Diversity

VIII. Carbohydrate on Immunoglobulins


5 Glycoproteins of other Specific Systems

Section 1 Glycoproteins and Glycolipids of the Nervous System

I. Introduction

II. Brain Glycoproteins

III. Brain Glycolipids

IV. Metabolism of Brain Glycoconjugates

V. The Functional Roles of Brain Glycoconjugates

VI. Glycoconjugates in Relation to Functional Stimulation, Learning, and Memory

VII. Conclusions and Perspectives


Section 2 Glycoenzymes and Glycohormones

I. Introduction

II. General

III. Glycoenzymes

IV. Glycohormones

V. Role of Carbohydrate


Section 3 Milk Glycoproteins and Oligosaccharides

I. Introduction

II. Glycoproteins and Glycopeptides

III. Oligosaccharides


Section 4 Urinary Glycoproteins, Glycopeptides, and Oligosaccharides

I. Introduction

II. Glycoproteins and Glycopeptides in Normal and Pathological Urine

III. Oligosaccharides in Normal and Pathological Urine

IV. Concluding Remarks


6 Chemistry of Mammalian Glycolipids

I. Introduction

II. Nomenclature

III. Methods of Isolation and Characterization of Glycosphingolipids

IV. History and Occurrence of Glycolipids

V. Distribution of Glycosphingolipids and Glycoglycerolipids




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© Academic Press 1977
Academic Press
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