The Glycoconjugates V3

The Glycoconjugates V3

Glycoproteins, Glycolipids and Proteoglycans

1st Edition - January 1, 1982

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  • Editor: Martin Horowitz
  • eBook ISBN: 9780323152631

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The Glycoconjugates: Mammalian Glycoproteins, Glycolipids, and Proteoglycans Volume III is a collaboration of different experts in the field of molecular biology on the subject of glycoconjugates. The third volume covers topics such as the glycosylation of proteins, inhibition of lipid-dependent glycosylation, and the relationship between translation and glycosylation. Also included are topics such as the intracellular transport of glycoproteins, the nonenzymatic glycosylation of proteins, and the glycosyltransferases and proteoglycans in the colon and B and T cells. The book is recommended for molecular biologists, organic chemists, and biochemists who would like to know more about glycolipids and glycoproteins and their applications.

Table of Contents

  • List of Contributors


    Contents of Previous Volumes

    1 Glycosylation of Proteins

    Section 1 Oligosaccharide Processing during Glycoprotein Biosynthesis

    I. Introduction

    II. Sequence of Oligosaccharide Processing

    III. Processing Enzymes

    IV. Alternate Processing Pathway

    V. Assembly of Phosphorylated High-Mannose Oligosaccharides

    VI. Regulation of Oligosaccharide Processing

    VII. Why Processing?


    Section 2 Glycosylation Pathways in the Biosynthesis of Nonreducing Terminal Sequences in Oligosaccharides of Glycoproteins

    I. Introduction

    II. Glycosyltransferases

    III. Biosynthesis of N-Linked Oligosaccharides

    IV. Biosynthesis of O-Linked Oligosaccharides


    Section 3 Inhibition of Lipid-Dependent Glycosylation

    I. Introduction

    II. The Dolichol Pathway of Protein Glycosylation

    III. Inhibitors of Protein Glycosylation

    IV. Biological Consequences of Inhibiting Glycosylation


    Section 4 The Variable Temporal Relationship between Translation and Glycosylation and Its Effect on the Efficiency of Glycosylation

    I. Overview of Glycoprotein Biosynthesis

    II. In Vivo and in Vitro Methods for Investigating the Temporal Relationship between Translation and Glycosylation

    III. Results Obtained on the Temporal Relationship between Translation and Glycosylation

    IV. Slowing of Peptide Elongation by Transfer of the Precursor Oligosaccharide to Nascent Chains

    V. Receptor Sites for Transfer of the Precursor Oligosaccharide Other Than Nascent Chains

    VI. Summary


    Section 5 Intracellular Transport of Glycoproteins

    I. Introduction

    II. Intracellular Transport of Nonmembranous Glycoproteins

    III. Intracellular Transport of Membrane-Bound Glycoproteins

    IV. Control of Intracellular Transport of Glycoproteins


    Section 6 Nonenzymatic Glycosylation of Proteins in Vitro and in Vivo

    I. Introduction

    II. Nonenzymatic Glycosylation of Hemoglobin and Other Proteins

    III. Relevance of Nonenzymatic Glucosylation to Pathophysiology of Diabetes


    2 Glycosylation and Development

    Section 1 Glycosyltransferases in the Differentiation of Slime Molds

    I. Introduction

    II. Development and Glycosyltransferase Activity


    Section 2 Cell Surface Glycosyltransferase Activities during Fertilization and Early Embryogenesis

    I. Introduction

    II. The Glycosyltransferases

    III. Necessary Controls for Assay of Surface-Associated Glycosyltransferases

    IV. Cell Surface Glycosyltransferases during Fertilization

    V. Cell Surface Glycosyltransferases during Embryogenesis

    VI. In Vitro Assays of Adhesive Recognition in Which the Role of Surface Glycosyltransferases Has Been Explored

    VII. Use of the T/t Complex Morphogenetic Mutants to Test Further the Involvement of Surface Glycosyltransferases in Cellular Interactions

    VIII. Conclusions and Future Directions


    Section 3 Glycosyltransferases in Fetal, Neonatal, and Adult Colon: Relationship to Differentiation

    I. Introduction

    II. Embryonic Development and Differentiation of Colon

    III. Colonic Glycoprotein Biosynthesis

    IV. Colonic Epithelial Glycosyltransferases

    V. Summary


    Section 4 Proteoglycans in Developing Embryonic Cartilage

    I. Introduction

    II. Cellular Aspects of Cartilage Development

    III. Sulfated Proteoglycan Structure

    IV. Proteoglycan Synthesis

    V. Extraction and Terminology of Proteoglycans

    VI. Proteoglycan Immunochemistry

    VII. Proteoglycans in Embryonic Cartilage

    VIII. Proteoglycan Changes during Chondrogenesis

    IX. Intracellular Proteins of Chondrocytes

    X. Conclusions


    Section 5 Membrane Glycoconjugates in the Maturation and Activation of T and B Lymphocytes

    I. Introduction

    II. Major Lymphocyte Subgroups

    III. Separation of T and B Lymphocytes

    IV. Lymphocytic Cell Lines and Leukemic Cells as Sources of Pure Lymphoid Cells

    V. Induction of Lymphoid Cell Division and Differentiation In Vitro

    VI. Characterization and Structure of Normal Lymphocyte Surface Glycoproteins

    VII. Lymphocyte Glycosphingolipids

    VII. Concluding Remarks


    Section 6 Expression of Glycosphingolipid Glycosyltransferases in Development and Transformation

    I. Introduction

    II. Biosynthesis of Gangliosides in Developing Animal Brains

    III. Biosynthesis of Blood-Group-Related Glycosphingolipids in Chemically Differentiated Cultured Cells

    IV. Biosynthesis in Vitro of Glycosphingolipids of the Forssman Family in Chemically Transformed Cultured Cells

    V. Conclusions


    3 Glycoconjugates in Cellular Adhesion and Aggregation

    Section 1 Fibronectin-Proteoglycan Binding as the Molecular Basis for Fibroblast Adhesion to Extracellular Matrices

    I. Cell Adhesion to Extracellular Matrices and Its Significance

    II. Biology of Fibroblast Adhesion to the Tissue Culture Substratum

    III. Biochemistry of Fibroblast Adhesion Sites

    IV. Glycosaminoglycans in Adhesion

    V. Supramolecular Interactions in Adhesion Sites

    VI. Molecular Model of Cell Substratum Adhesion


    Section 2 Biochemistry of Fibronectin

    I. Introduction

    II. Biological Activities in Fibronectin

    III. Structure of Fibronectin

    IV. Structures of Cellular versus Plasma Fibronectins

    V. Cellular Receptor for Fibronectin

    VI. Synthesis and Regulation

    VII. Prospects



Product details

  • No. of pages: 390
  • Language: English
  • Copyright: © Academic Press 1982
  • Published: January 1, 1982
  • Imprint: Academic Press
  • eBook ISBN: 9780323152631

About the Editor

Martin Horowitz

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