The Glycoconjugates V2

The Glycoconjugates V2

Mammalian Glycoproteins and Glycolipids and Proteoglycans

1st Edition - January 1, 1978

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  • Editor: Martin Horowitz
  • eBook ISBN: 9780323148832

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The Glycoconjugates: Mammalian Glycoproteins, Glycolipids, and Proteoglycans Volume II is a collaboration of different experts in the field of molecular biology on the subject of glycoconjugates. The text of the second volume covers topics such as the structure and biosynthesis of connective tissue proteoglycans, glycoproteins, and glycolipids; and glycoprotein and glycolipid catabolism and degradation. It also discusses the structure, composition, and isolation of surface membranes; and lectins – its immunological aspects and its use in the study of mammalian glycoprotein. The book is recommended for molecular biologists, organic chemists, and biochemists who would like to know more about glycolipids and glycoproteins and their applications.

Table of Contents

  • List of Contributors


    Contents of Volume I

    1 Proteoglycans and Structural Glycoproteins

    Section 1 Structure and Biosynthesis of Connective Tissue Proteoglycans

    I. Introduction

    II. Hyaluronic Acid

    III. Chondroitin Sulfate Proteoglycans

    IV. Heparin

    V. Acidic Glycosaminoglycans and the Cell Nucleus


    Section 2 Connective Tissue Glycoproteins



    Section 3 The Carbohydrate of Collagen

    I. Introduction

    II. Structure and Linkage of Hexose

    III. Occurrence in the Different Collagen Types

    IV. Biosynthesis of Hydroxylysine and the Attachment of Carbohydrate


    2 Glycoprotein Biosynthesis

    I. Introduction

    II. Biosynthesis of Monosaccharides and Their Activated Derivatives

    III. Biosynthesis of Asn-GlcNAc-Type Oligosaccharides of Secretory Glycoproteins

    IV. Biosynthesis of Ser(Thr)-GalNAc-Type Oligosaccharides of Secretory Glycoproteins

    V. Biosynthesis of Membrane-Bound Glycoproteins

    VI. The Control of Glycoprotein Biosynthesis


    3 Glycoprotein Catabolism

    Section 1 Degradation of Glycoproteins

    I. Introduction

    II. Role of Lysosomes

    III. Specific Enzymes Involved in Degradation of Glycoproteins

    IV. Proteolytic Enzymes of Lysosomes

    V. Estimates of Degradation and Daily Turnover

    VI. Disorders of Glycoprotein Catabolism


    Section 2 Signals for Degradation of Glycoproteins



    Section 3 Degradation of Mucus Glycoproteins in the Gastrointestinal Tract

    I. Introduction

    II. Degradation of Mucus Glycoproteins by Digestive Secretions

    III. Degradation of Mucus Glycoproteins by the Enteric Microflora

    IV. Some Pathophysiological and Biological Implications


    4 Glycolipid Biosynthesis

    I. Introduction

    II. The Biosynthesis of Ceramide

    III. Synthesis of 1-O-Galactosylceramide

    IV. Biosynthesis of Galactosyldiglycerides in Nervous Tissue and Their Association with Myelin

    V. Biosynthesis of Sulfatide (GL-1bS)

    VI. Biosynthesis of Sulfogalactolipid and Its Role in the Developmental Biology of the Testis

    VII. Biosynthesis of Digalactosylceramide (GL-2b)

    VIII. Biosynthesis of 1-O-Sialogylcosphingolipids (Gangliosides)

    IX. Biosynthesis of Neutral Glycosphingolipids

    X. Biosynthesis of Glycosphingolipids with Blood Group Activity

    XI. Regulation of Glycosphingolipid Synthesis in Cultured Cells

    XII. Conclusions


    5 Glycolipid Catabolism

    I. Introduction

    II. The Role of Neuraminidase in Glycosphingolipid Catabolism

    III. The Role of β-Galactosidases in Glycolipid Catabolism

    IV. The Role of N-Acetyl-β-Hexosaminidase in Glycolipid Catabolism

    V. The Role of β-Glucosidase in Glycolipid Catabolism

    VI. Ceramidase

    VII. The Metabolic Fate of Sphingosine

    VIII. Arylsulfatase A (Cerebroside Sulfate Sulfatase)

    IX. α-Galactosidase

    X. α-L-Fucosidase

    XI. Role of Lysosomal Glycosphingolipid Hydrolases in Other Human Diseases

    XII. Enzyme Replacement Therapy

    XIII. Inborn Errors of Glycoprotein Catabolism

    XIV. Conclusions as to the Role of Glycosphingolipid Catabolism in Mammalian Cell Metabolism


    6 Surface Membranes

    I. Introduction

    II. Membrane Structure

    III. Isolation of Surface Membranes

    IV. Composition

    V. Relationship to Biological Phenomena

    VI. Comments


    7 Immunological Aspects and Lectins

    Section 1 Immunological Aspects

    I. Introduction

    II. Background

    III. Immunochemistry and Immunogenetics of Blood Group Antigens

    IV. Serological Reactions of Glycolipids

    V. Immunochemistry of Sialic Acid

    VI. Histocompatibility Antigens

    VII. Immunology and Cancer


    Section 2 Use of Lectins in the Study of Mammalian Glycoproteins

    I. Introduction

    II. Methods of Isolation

    III. Carbohydrate-Binding Specificity

    IV. Useful Properties of Lectins



Product details

  • No. of pages: 480
  • Language: English
  • Copyright: © Academic Press 1978
  • Published: January 1, 1978
  • Imprint: Academic Press
  • eBook ISBN: 9780323148832

About the Editor

Martin Horowitz

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