The Glycoconjugates V2 - 1st Edition - ISBN: 9780123561022, 9780323148832

The Glycoconjugates V2

1st Edition

Mammalian Glycoproteins and Glycolipids and Proteoglycans

Editors: Martin Horowitz
eBook ISBN: 9780323148832
Imprint: Academic Press
Published Date: 1st January 1978
Page Count: 480
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The Glycoconjugates: Mammalian Glycoproteins, Glycolipids, and Proteoglycans Volume II is a collaboration of different experts in the field of molecular biology on the subject of glycoconjugates.

The text of the second volume covers topics such as the structure and biosynthesis of connective tissue proteoglycans, glycoproteins, and glycolipids; and glycoprotein and glycolipid catabolism and degradation. It also discusses the structure, composition, and isolation of surface membranes; and lectins – its immunological aspects and its use in the study of mammalian glycoprotein.

The book is recommended for molecular biologists, organic chemists, and biochemists who would like to know more about glycolipids and glycoproteins and their applications.

Table of Contents

List of Contributors


Contents of Volume I

1 Proteoglycans and Structural Glycoproteins

Section 1 Structure and Biosynthesis of Connective Tissue Proteoglycans

I. Introduction

II. Hyaluronic Acid

III. Chondroitin Sulfate Proteoglycans

IV. Heparin

V. Acidic Glycosaminoglycans and the Cell Nucleus


Section 2 Connective Tissue Glycoproteins



Section 3 The Carbohydrate of Collagen

I. Introduction

II. Structure and Linkage of Hexose

III. Occurrence in the Different Collagen Types

IV. Biosynthesis of Hydroxylysine and the Attachment of Carbohydrate


2 Glycoprotein Biosynthesis

I. Introduction

II. Biosynthesis of Monosaccharides and Their Activated Derivatives

III. Biosynthesis of Asn-GlcNAc-Type Oligosaccharides of Secretory Glycoproteins

IV. Biosynthesis of Ser(Thr)-GalNAc-Type Oligosaccharides of Secretory Glycoproteins

V. Biosynthesis of Membrane-Bound Glycoproteins

VI. The Control of Glycoprotein Biosynthesis


3 Glycoprotein Catabolism

Section 1 Degradation of Glycoproteins

I. Introduction

II. Role of Lysosomes

III. Specific Enzymes Involved in Degradation of Glycoproteins

IV. Proteolytic Enzymes of Lysosomes

V. Estimates of Degradation and Daily Turnover

VI. Disorders of Glycoprotein Catabolism


Section 2 Signals for Degradation of Glycoproteins



Section 3 Degradation of Mucus Glycoproteins in the Gastrointestinal Tract

I. Introduction

II. Degradation of Mucus Glycoproteins by Digestive Secretions

III. Degradation of Mucus Glycoproteins by the Enteric Microflora

IV. Some Pathophysiological and Biological Implications


4 Glycolipid Biosynthesis

I. Introduction

II. The Biosynthesis of Ceramide

III. Synthesis of 1-O-Galactosylceramide

IV. Biosynthesis of Galactosyldiglycerides in Nervous Tissue and Their Association with Myelin

V. Biosynthesis of Sulfatide (GL-1bS)

VI. Biosynthesis of Sulfogalactolipid and Its Role in the Developmental Biology of the Testis

VII. Biosynthesis of Digalactosylceramide (GL-2b)

VIII. Biosynthesis of 1-O-Sialogylcosphingolipids (Gangliosides)

IX. Biosynthesis of Neutral Glycosphingolipids

X. Biosynthesis of Glycosphingolipids with Blood Group Activity

XI. Regulation of Glycosphingolipid Synthesis in Cultured Cells

XII. Conclusions


5 Glycolipid Catabolism

I. Introduction

II. The Role of Neuraminidase in Glycosphingolipid Catabolism

III. The Role of β-Galactosidases in Glycolipid Catabolism

IV. The Role of N-Acetyl-β-Hexosaminidase in Glycolipid Catabolism

V. The Role of β-Glucosidase in Glycolipid Catabolism

VI. Ceramidase

VII. The Metabolic Fate of Sphingosine

VIII. Arylsulfatase A (Cerebroside Sulfate Sulfatase)

IX. α-Galactosidase

X. α-L-Fucosidase

XI. Role of Lysosomal Glycosphingolipid Hydrolases in Other Human Diseases

XII. Enzyme Replacement Therapy

XIII. Inborn Errors of Glycoprotein Catabolism

XIV. Conclusions as to the Role of Glycosphingolipid Catabolism in Mammalian Cell Metabolism


6 Surface Membranes

I. Introduction

II. Membrane Structure

III. Isolation of Surface Membranes

IV. Composition

V. Relationship to Biological Phenomena

VI. Comments


7 Immunological Aspects and Lectins

Section 1 Immunological Aspects

I. Introduction

II. Background

III. Immunochemistry and Immunogenetics of Blood Group Antigens

IV. Serological Reactions of Glycolipids

V. Immunochemistry of Sialic Acid

VI. Histocompatibility Antigens

VII. Immunology and Cancer


Section 2 Use of Lectins in the Study of Mammalian Glycoproteins

I. Introduction

II. Methods of Isolation

III. Carbohydrate-Binding Specificity

IV. Useful Properties of Lectins




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© Academic Press 1978
Academic Press
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About the Editor

Martin Horowitz

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