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The Genetics of Circadian Rhythms - 1st Edition - ISBN: 9780123876904, 9780123876980

The Genetics of Circadian Rhythms, Volume 74

1st Edition

Serial Volume Editor: Stuart Brody
Hardcover ISBN: 9780123876904
eBook ISBN: 9780123876980
Imprint: Academic Press
Published Date: 26th September 2011
Page Count: 264
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Table of Contents

  • Series Page
  • Contributors
  • Introduction
    • I. Introduction
    • II. An Unofficial, Abbreviated/Annotated Version of the History of the Genetics of Circadian Rhythms
    • III. Common Themes
    • IV. Some Reflections
  • The Itty-Bitty Time Machine
    • Abbreviations
    • I. Introduction
    • II. The Kai-Based Oscillator: Early Studies
    • III. KaiC: Breakthroughs into Oscillator Timing and Clock Synchronization
    • IV. Input Pathways: Light-Dependent Cellular Metabolism Synchronizes the Clock with Local Time
    • V. Output Pathways: Multiple Independent Pathways Merge to Coordinate Cellular and Physiological Processes
    • VI. Conclusions
    • Acknowledgments
  • The Genetics of Circadian Rhythms in Neurospora
    • I. Introduction
    • II. Early Genetic Analysis
    • III. The Genetics and Biochemistry of the FRQ/WCC Feedback Loop
    • IV. Other Clock-Associated Genes
    • V. FRQ-Less Rhythms
    • VI. Clock-Controlled Genes
    • VII. Outlook
  • The Genetics of Plant Clocks
    • I. Introduction
    • II. Genome-Wide Characterization of Circadian-Regulated Genes and Processes
    • III. Molecular Organization of Plant Circadian Clocks into Interlocked Transcriptional Feedback Loops
    • IV. Conservation of Clock Genes
    • V. Circadian Clocks Enhance Fitness
    • VI. Concluding Remarks
    • Acknowledgment
  • Molecular Genetic Analysis of Circadian Timekeeping in Drosophila
    • I. Introduction
    • II. The Circadian Feedback Loops of Drosophila
    • III. Posttranscriptional Regulation of Rhythmic Transcription
    • IV. Light Entrainment of the Drosophila Circadian Feedback Loops
    • V. Summary and Conclusions
    • Acknowledgments
  • Genetics of Circadian Rhythms in Mammalian Model Organisms
    • I. Introduction
    • II. The Beginning of Mammalian Clock Genetics
    • III. Overview of the Mammalian Clock System
    • IV. The Mammalian Circadian Molecular Oscillator
    • V. Behavioral, Molecular, and Cell/Tissue Effects of Circadian Clock Gene Mutations
    • VI. Posttranslational Modification of Clock Proteins
    • VII. Posttranscriptional Clock Mechanisms
    • VIII. Effects of Temperature on the Mammalian Clock
    • IX. Unresolved Issues and Future Directions
    • X. Conclusion
    • Acknowledgments
  • The Genetics of the Human Circadian Clock
    • I. Human Circadian Phenotypes
    • II. Insights Gained from Familial Advanced Sleep Phase Syndrome
    • III. Insights Gained from Association Studies
    • IV. Future Directions


This latest volume in Advances in Genetics covers the genetics of Circadian rhythms. With an international  group of authors this volume is the latest offering in this widely praised series.


Geneticists, molecular biologists, neurobiologists


No. of pages:
© Academic Press 2011
26th September 2011
Academic Press
Hardcover ISBN:
eBook ISBN:

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About the Serial Volume Editor

Stuart Brody