The Genetics of Cancer

1st Edition

Genes Associated with Cancer Invasion, Metastasis and Cell Proliferation

Authors: Gajanan Sherbet M. Lakshmi
Print ISBN: 9780123909428
eBook ISBN: 9780080542485
Imprint: Academic Press
Published Date: 22nd June 1997
Page Count: 338
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Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology.

Key Features

@introbul:Key Features @bul:The contents include:

  • Clonal evolution of the metastasis phenotype
  • Cell Cycle regulation
  • Apoptosis in tumour growth and metastasis
  • Angiogenesis in cancer
  • Cell surface glycoproteins and their receptors
  • Proteinases and their inhibitors in cancer invasion
  • Oncogenes and cancer metastasis
  • Developmental genes
  • Tumour suppressor genes
  • Metastasis suppressor genes
  • Dominant metastasis-associated genes


Graduates, research scientists, and research clinicians in cancer biology, oncology, pathology, genetics, molecular biology, and biomedicine in general.

Table of Contents

Preface. Acknowledgement. Introduction. Clonal Evolution of Metastasis. Inefficiency of the Metastatic Process. Tumor Growth and Metastatic Potential. Cell Cycle Regulation and Metastasis. Apoptosis in Tumor Growth and Metastasis. Angiogenesis in Cancer. Cell Surface Glycoproteins and Their Receptors. Proteinases and Their Inhibitors in Cancer Invasion. Oncogenes and Cancer Metastasis. Developmental Genes and Their Putative Tumor Suppressor Function. Tumor Suppressor Genes. Metastasis Suppressor Genes. Dominant Metastasis Associated Genes. Epilogue. References.


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© Academic Press 1997
Academic Press
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About the Author

Gajanan Sherbet

Dr. G.V. Sherbet is DSc (Doctor of Science) London University; FRCPath (Fellow of the Royal College of Pathologists). He was a member of the scientific staff at the Chester Beatty Research Institute and University College Medical School of London, and Deputy Director of the Cancer Research Unit in the Medical School of University of Newcastle upon Tyne. He has held several prestigious fellowships, such as the Beit Memorial and the Williams and Cancer Research Campaign fellowships. Dr Sherbet is Adjunct professor at the Institute for Molecular Medicine Huntington Beach CA. He is on the editorial boards of many international scientific and medical journals.

Affiliations and Expertise

School of Electrical Electronic and Computer Engineering,University of Newcastle upon Tyne UK and The Institute for Molecular Medicine, Huntington Beach, CA, USA

M. Lakshmi

Dr. M.S. Lakshmi has held academic appointments at Johns Hopkins University in Baltimore, Harvard University, University of Bonn as Alexander von Humboldt Fellow, University of Edinburgh, Chester Beatty Research Institute in London, University of Nottingham in the Cancer Research Campaign Laboratories, and University College Medical School in London. She is presently a senior research scientist in the Cancer Research Unit at the University of Newcastle upon Tyne.

Affiliations and Expertise

Cancer Research Unit, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, U.K.


@qu:"Overall this book provides an excellent and often critical overview of the current state of knowledge of the genes associated with invasion and metastasis and those processes associated with it. It is a very good source of references for seminal papers and reviews, which are quite will make a very useful and readable introduction to the genetics of tumor invasion and metastasis and to the concepts that underlie it." @source:--PATHOLOGY @qu:"The book's greatest strength is in compiling and extensively referencing the massive and often paradoxical clinical literature correlating the expression patterns of cancer genes with different tumor phenotypes." @source:--NATURE MEDICINE