The Genetics of Cancer - 1st Edition - ISBN: 9780126398755, 9780080542485

The Genetics of Cancer

1st Edition

Genes Associated with Cancer Invasion, Metastasis and Cell Proliferation

Authors: Gajanan Sherbet M. Lakshmi
eBook ISBN: 9780080542485
Hardcover ISBN: 9780126398755
Imprint: Academic Press
Published Date: 22nd June 1997
Page Count: 338
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Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology.

Key Features

  • Clonal evolution of the metastasis phenotype
  • Cell Cycle regulation
  • Apoptosis in tumour growth and metastasis
  • Angiogenesis in cancer
  • Cell surface glycoproteins and their receptors
  • Proteinases and their inhibitors in cancer invasion
  • Oncogenes and cancer metastasis
  • Developmental genes
  • Tumour suppressor genes
  • Metastasis suppressor genes
  • Dominant metastasis-associated genes


Graduates, research scientists, and research clinicians in cancer biology, oncology, pathology, genetics, molecular biology, and biomedicine in general

Table of Contents

Clonal Evolution of Metastasis
Inefficiency of the Metastatic Process
Tumor Growth and Metastatic Potential
Cell Cycle Regulation and Metastasis
Apoptosis in Tumor Growth and Metastasis
Angiogenesis in Cancer
Cell Surface Glycoproteins and Their Receptors
Proteinases and Their Inhibitors in Cancer Invasion
Oncogenes and Cancer Metastasis
Developmental Genes and Their Putative Tumor Suppressor Function
Tumor Suppressor Genes
Metastasis Suppressor Genes
Dominant Metastasis Associated Genes


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© Academic Press 1997
Academic Press
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About the Author

Gajanan Sherbet

Dr. Gajanan V. Sherbet is Doctor of Science of London University and Fellow of the Royal College of Pathologists and the Royal Society of Chemistry. He is member of the editorial boards of many scientific and medical journals, and formerly editor of Experimental Cell Biology and Pathobiology. Dr. Sherbet’s major scientific interest is in cancer metastasis. He has focused on the role of growth factors and their signaling, and the calcium binding protein S100A4 in cell proliferation, cancer invasion and metastasis; also he is currently studying the potential of artificial neural networks for predicting breast cancer progression and prognosis. Dr. Sherbet has numerous scientific papers in international journals and has written and edited several books on cancer, such as Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy (2011) and Therapeutic Strategies in Cancer Biology and Pathology (2013), and e-books on the role of growth factors and their receptors in cancer therapy and therapeutic strategies in cancer biology and molecular pathology.

Affiliations and Expertise

Professor, Institute for Molecular Medicine, Huntington Beach CA, USA and Professor (visiting), School of Electrical and Electronic Engineering, University of Newcastle upon Tyne, UK

M. Lakshmi

Dr. M.S. Lakshmi has held academic appointments at Johns Hopkins University in Baltimore, Harvard University, University of Bonn as Alexander von Humboldt Fellow, University of Edinburgh, Chester Beatty Research Institute in London, University of Nottingham in the Cancer Research Campaign Laboratories, and University College Medical School in London. She is presently a senior research scientist in the Cancer Research Unit at the University of Newcastle upon Tyne.

Affiliations and Expertise

Cancer Research Unit, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, U.K.


"Overall this book provides an excellent and often critical overview of the current state of knowledge of the genes associated with invasion and metastasis and those processes associated with it. It is a very good source of references for seminal papers and reviews, which are quite will make a very useful and readable introduction to the genetics of tumor invasion and metastasis and to the concepts that underlie it." --PATHOLOGY

"The book's greatest strength is in compiling and extensively referencing the massive and often paradoxical clinical literature correlating the expression patterns of cancer genes with different tumor phenotypes." --NATURE MEDICINE