The Genetics of Cancer

The Genetics of Cancer

Genes Associated with Cancer Invasion, Metastasis and Cell Proliferation

1st Edition - June 22, 1997

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  • Authors: Gajanan Sherbet, M. Lakshmi
  • eBook ISBN: 9780080542485

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Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology.

Key Features

  • Clonal evolution of the metastasis phenotype
  • Cell Cycle regulation
  • Apoptosis in tumour growth and metastasis
  • Angiogenesis in cancer
  • Cell surface glycoproteins and their receptors
  • Proteinases and their inhibitors in cancer invasion
  • Oncogenes and cancer metastasis
  • Developmental genes
  • Tumour suppressor genes
  • Metastasis suppressor genes
  • Dominant metastasis-associated genes


Graduates, research scientists, and research clinicians in cancer biology, oncology, pathology, genetics, molecular biology, and biomedicine in general

Table of Contents

  • Clonal Evolution of Metastasis
    Inefficiency of the Metastatic Process
    Tumor Growth and Metastatic Potential
    Cell Cycle Regulation and Metastasis
    Apoptosis in Tumor Growth and Metastasis
    Angiogenesis in Cancer
    Cell Surface Glycoproteins and Their Receptors
    Proteinases and Their Inhibitors in Cancer Invasion
    Oncogenes and Cancer Metastasis
    Developmental Genes and Their Putative Tumor Suppressor Function
    Tumor Suppressor Genes
    Metastasis Suppressor Genes
    Dominant Metastasis Associated Genes

Product details

  • No. of pages: 338
  • Language: English
  • Copyright: © Academic Press 1997
  • Published: June 22, 1997
  • Imprint: Academic Press
  • eBook ISBN: 9780080542485

About the Authors

Gajanan Sherbet

Dr. Gajanan V. Sherbet is Doctor of Science of London University and Fellow of the Royal College of Pathologists and the Royal Society of Chemistry. He is member of the editorial boards of many scientific and medical journals, and formerly editor of Experimental Cell Biology and Pathobiology. Dr. Sherbet’s major scientific interest is in cancer metastasis. He has focused on the role of growth factors and their signaling, and the calcium binding protein S100A4 in cell proliferation, cancer invasion and metastasis; also he is currently studying the potential of artificial neural networks for predicting breast cancer progression and prognosis. Dr. Sherbet has numerous scientific papers in international journals and has written and edited several books on cancer, such as Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy (2011) and Therapeutic Strategies in Cancer Biology and Pathology (2013), and e-books on the role of growth factors and their receptors in cancer therapy and therapeutic strategies in cancer biology and molecular pathology.

Affiliations and Expertise

Professor, Institute for Molecular Medicine, Huntington Beach CA, USA and Professor (visiting), School of Electrical and Electronic Engineering, University of Newcastle upon Tyne, UK

M. Lakshmi

Dr. M.S. Lakshmi has held academic appointments at Johns Hopkins University in Baltimore, Harvard University, University of Bonn as Alexander von Humboldt Fellow, University of Edinburgh, Chester Beatty Research Institute in London, University of Nottingham in the Cancer Research Campaign Laboratories, and University College Medical School in London. She is presently a senior research scientist in the Cancer Research Unit at the University of Newcastle upon Tyne.

Affiliations and Expertise

Cancer Research Unit, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, U.K.

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