The Flaviviruses: Structure, Replication and Evolution, Volume 59

1st Edition

Serial Volume Editors: Thomas Chambers Thomas Monath
Hardcover ISBN: 9780120398591
eBook ISBN: 9780080493817
Imprint: Academic Press
Published Date: 10th December 2003
Page Count: 369
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Table of Contents

Taxonomy of the virus family Flaviviridae Structure and replication Molecular Biology of the Flaviviruses Flavivirus Structure and Membrane Fusion Kunjin RNA replication and applications of Kunjin replicons Antigenic structure of flavivirus Proteins 5' and 3' non-coding regions in flavivirus RNA Manipulation of Cell Surface Macromolecules by Flaviviruses Flavivirus evolution Origins, Evolution and vecto/host cp-adaptations within the genus Flavivirus Microevolution and virulence of dengue viruses


Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat.

Structure, Replication and Evolution is the first volume of The Flaviviruses and presents the latest research covering the conceptual advances on aspects such as the characterization of virus structure, cellular receptors, mechanisms of virus entry, host and viral components of the RNA replicase.

Key Features

  • Includes new, detailed information on the evolution, viral structure and replication of the Flavivirus family
  • The only complete reference book on a major virus family
  • Descibes the technologies that have contributed to our current knowledge about Flaviviruses
  • Identifies the major problems faced in understanding the virus-host interactions that result in disease


Virologists, molecular epidemologists, clinicians and public health specialists, immunologists, and researchers in vaccine development


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© Academic Press 2003
Academic Press
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"...the chapters are well written, and the editors have ensured continuity of a high standard of writing throughout the set...Given the wealth of information, with contributions by over 60 authors, The Flavaviruses, really is an essential series of books that belongs on every arbovirologists’ bookshelf." -Stephen Higgs, Ph.D., University of Texas Medical Branch, U.S., (2004)

About the Serial Volume Editors

Thomas Chambers Serial Volume Editor

Thomas Monath Serial Volume Editor

Affiliations and Expertise