The Flaviviruses: Structure, Replication and Evolution

The Flaviviruses: Structure, Replication and Evolution

1st Edition - December 10, 2003

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  • Editors: Thomas Chambers, Thomas Monath
  • eBook ISBN: 9780080493817

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Description

Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Structure, Replication and Evolution is the first volume of The Flaviviruses and presents the latest research covering the conceptual advances on aspects such as the characterization of virus structure, cellular receptors, mechanisms of virus entry, host and viral components of the RNA replicase.

Key Features

  • Includes new, detailed information on the evolution, viral structure and replication of the Flavivirus family
  • The only complete reference book on a major virus family
  • Descibes the technologies that have contributed to our current knowledge about Flaviviruses
  • Identifies the major problems faced in understanding the virus-host interactions that result in disease

Readership

Virologists, molecular epidemologists, clinicians and public health specialists, immunologists, and researchers in vaccine development

Table of Contents

  • Taxonomy of the virus family Flaviviridae
    Structure and replication
    Molecular Biology of the Flaviviruses
    Flavivirus Structure and Membrane Fusion
    Kunjin RNA replication and applications of Kunjin replicons
    Antigenic structure of flavivirus Proteins
    5' and 3' non-coding regions in flavivirus RNA
    Manipulation of Cell Surface Macromolecules by Flaviviruses
    Flavivirus evolution
    Origins, Evolution and vecto/host cp-adaptations within the genus Flavivirus
    Microevolution and virulence of dengue viruses

Product details

  • No. of pages: 369
  • Language: English
  • Copyright: © Academic Press 2003
  • Published: December 10, 2003
  • Imprint: Academic Press
  • eBook ISBN: 9780080493817

About the Serial Volume Editors

Thomas Chambers

Thomas Monath

Affiliations and Expertise

1

About the Serial Editors

Karl Maramorosch

Professor Karl Maramorosch works at Rutgers University, New Brunswick, NJ, USA.

Affiliations and Expertise

Rutgers University, New Brunswick, NJ, USA

Aaron Shatkin

Affiliations and Expertise

Center for Advanced Biotechnology and Medicine, Piscataway, NJ, USA

Frederick Murphy

Frederick Murphy
Frederick A. Murphy, DVM, PhD, is professor, Department of Pathology, University of Texas Medical Branch (UTMB), Galveston. He holds a BS and DVM from Cornell University and a PhD from the University of California, Davis (UC Davis). Formerly he was dean and distinguished professor, School of Veterinary Medicine, and distinguished professor, School of Medicine, UC Davis. Before that he served as director of the National Center for Infectious Diseases, and director of the Division of Viral and Rickettsial Diseases, Centers for Disease Control, Atlanta. He is a member of the Institute of Medicine of the U.S. National Academy of Sciences and is a member of the German National Academy of Sciences and the Belgian Royal Academy of Medicine. He holds an honorary Doctor of Medicine and Surgery from the University of Turku, Finland; an honorary Doctor of Science from the University of Guelph, Canada; an honorary Doctor of Veterinary Medicine from the University of London, United Kingdom; an honorary Doctor of Science from University College Dublin, Ireland; the Presidential Rank Award of the U.S. Government; the PennVet World Leadership Award from the University of Pennsylvania, and the Distinguished Microbiologist Award from the American College of Veterinary Microbiologists. At UTMB, he is a member of the Institute for Human Infections and Immunity, Center for Biodefense and Emerging Infectious Diseases, Galveston National Laboratory, and McLaughlin Endowment for Infection and Immunity. His professional interests include the pathology and epidemiology of highly pathogenic viruses/viral diseases: rabies and the rabies-like viruses, arboviruses, hemorrhagic fever viruses, and other neurotropic viruses. He has been a leader in advancing the concepts of “new and emerging infectious diseases” and “new and emerging zoonoses” and “the threat posed by bioterrorism.” Most recently, he has been working on Internet resources on the history of virology: “The Foundations of Virology” at http://www.utmb.edu/virusimages/.

Affiliations and Expertise

University of Texas Medical Branch, Galveston, TX, USA

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