This volume presents a basic consensus of how the aqueous humor is formed and exits through the trabecular meshwork and canal of Schlemm. It presents a timely update to current knowledge of the molecular transport mechanisms which underlie aqueous humor dynamics. In addition, it provides a concise description of the clinical approaches used for assessing these basic transport processes. The book emphasizes the phenomenon of the diurnal rhythm of aqueous humor formation, from both the clinical and molecular points of view. This phenomenon provides the major indication that aqueous humor secretion is regulated.

Key Features

@introbul:Key Features @bul:* Introduces the mechanisms of aqueous humor formation and outflow * Describes the clinical study of aqueous humor dynamics * Exposes the research approaches currently applied * Emphasizes the diurnal rhythm of aqueous humor secretion * Provides awareness of unanswered questions


Physiologists, molecular and cell biologists, pharmacologists, and clinical investigators (ophthalmologists).

Table of Contents

M.M. Civan, Overview: Transport Components of Aqueous Humor Secretion and Their Regulation. M. Coca-Prados and J. Sanchez-Torres, Molecular Approaches to the Study of the Na+, K+-ATPase and Chloride Channels in the Ocular Ciliary Epithelium. T. Jacob, Chloride Channels in the Ciliary Epithelium. J. Rae and A.R. Shepard, The Identification of Potassium Channels in Human Lens Epithelium. M.D. Lee, L.S. King, and P. Agre, Aquaporin Water Channels in Eye and Other Channels. J.M. Wolosin and M. Schutte, Gap Junctions and Interlayer Communication in the Heterocellular Epithelium of the Ciliary Body. M. Wiederholt and F. Stumpff, The Travecular Meshwork and Aqueous Humor Reabsorption. J. Sears and M.L. Sears, Circadian Rhythms in Aqueous Humor Formation. R.F. Brubaker, Clinical Measurements of Aqueous Dynamics: Implications for Addressing Glaucoma. Index.


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© 1998
Academic Press
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