The Eye

1st Edition, Volume 4 - March 31, 2023
Editors: Eman E. Taher, Mohamed Elalfy
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 9 8 7 - 8
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 3 1 6 - 7

The Eye, Volume Four, the latest release in the Stem Cell Innovation in Health and Disease series, addresses the recent data accumulated on the potential applications of… Read more

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The Eye, Volume Four, the latest release in the Stem Cell Innovation in Health and Disease series, addresses the recent data accumulated on the potential applications of stem cells to treat eye diseases. This volume highlights the recent development of cutting-edge in vitro and in vivo research tools and approaches, including human and murine organoid cultures, genetic editing in vitro and in vivo, human iPSC models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure eye diseases.

The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation, and is contributed by world-renowned authors in the field. This is a timely and fascinating collection of information and new discoveries that provides a contemporary snapshot album on the fast-moving field of regenerative medicine and stem cell therapeutics.

Cover image
Title page
Table of Contents
Copyright
Dedication
List of contributors
About the editors
Foreword
Preface
Epigraph
Chapter 1. Stem cell-based organoid cultures as innovative approaches for ocular repair and regeneration
Abstract
1.1 Cornea
1.2 Retina
1.3 Retinal ganglion cells and the optic nerve
Conflict of interest
References
Chapter 2. Organoid-based modality of eye function and cellular processes
Abstract
Abbreviations
Brief description of the eye structure
2.1 The need for innovative tools for eye biology, function, and diseases
2.2 Roles of the organoid culture in the cornea
2.3 Retina
2.4 Lacrimal glands
2.5 Lacrimal gland organoid cultures
2.6 Lens
2.7 Discussion and conclusion
References
Chapter 3. Leveraging neural crest pluripotency to extend retinal and craniofacial niches for building neurovascular organoids—a theranostic and drug development perspective
Abstract
3.1 Introduction
3.2 Summary, conclusion, and future perspective
Acknowledgments
Disclaimer
References
Further reading
Chapter 4. Role of stem cell engineering and or gene-editing technologies in eye diseases degeneration, and therapy
Abstract
4.1 Introduction
4.2 Introducing stem cells
4.3 Induced pluripotent stem cell
4.4 Retina, retinal pigment epithelium
4.5 Examples of iPSCs implications in eye diseases
4.6 AMD
4.7 Photoreceptor cell disorders
4.8 RPE disorders
4.9 Eye disease and stem cell therapy
4.10 Gene therapy
4.11 Eye-related disorders
4.12 Conclusion
References
Chapter 5. Stem cells and genetic engineering empower therapeutic development for blinding eye diseases
Abstract
5.1 Introduction
5.2 Stem cell therapy in eye diseases
5.3 Gene therapy in eye diseases
5.4 Conclusion
Acknowledgements
References
Chapter 6. Human stem cell-derived retinal pigment epithelial cells for retinal regeneration: differentiation and clinical translation
Abstract
6.1 Introduction
6.2 Differentiation of retinal pigment epithelium cells from human stem cells
6.3 Characteristics of HSC-RPE cells
6.4 Clinical translation of HSC-RPE cells
6.5 Discussion
Acknowledgments
References
Further reading
Chapter 7. Mesenchymal stem cells therapy for retinal diseases
Abstract
Abbreviations
7.1 Introduction
7.2 Challenges and prospects
7.3 Summary and conclusions
References
Chapter 8. Retinal cone photoreceptors from pluripotent stem cells for macular regeneration
Abstract
8.1 Introduction
8.2 Mouse ESCs and PSCs-derived cone photoreceptors
8.3 Human ESCs and PSCs-derived cone photoreceptors
8.4 Transplantation of PSC-derived cone photoreceptors
8.5 Conclusions
Acknowledgments
References
Chapter 9. Update on stem/progenitor cell-based clinical trials for eye disease
Abstract
9.1 Retinal stem cell studies
9.2 Limbal stem cells studies
References
Chapter 10. Stem cell innovation in eye disease, repair and regeneration: general conclusion, challenges and prospective
Abstract
Abbreviations
10.1 Introduction
10.2 Roles of the organoids in modeling and investigating eye diseases
10.3 Roles of stem cells and genetic engineering technologies in empowering therapeutic development for blinding eye diseases
10.4 Application of stem cell types in eye diseases
Conflicts of interest
References
Index

Eman E. Taher

Dr. Eman E. Taher is a Professor in the Department of Microbiology and Clinical Parasitology at the Research Institute of Ophthalmology. The institute studies and performs different diagnostic techniques for parasites especially those affecting the eyes. Dr. Taher is the head of the Clinical Parasitology Unit. His extensive work has been on the diagnosis of Acanthamoeba, Toxoplasma, Toxocara and Schistosomiasis, as well as other different parasites, which has yielded over 20 papers, with different faculties, post-doctoral fellows and students. Additionally, Dr. Taher has also completed extensive research on different molecular diagnostic techniques for different parasites including electrophoresis, PCR, Western blot, DNA-extraction, ELISA and dot-ELISA. In addition, to stem cell preparation, characterization being a member of the stem cell laboratory at the Research Institute of Ophthalmology, he earned a six–month scholarship at the Eye and Ear Institute, Pittsburgh University, USA. His research portfolio includes variable papers on different parasites.

Affiliations and expertise

Professor, Department of Microbiology and Clinical Parasitology, Research Institute of Ophthalmology, Cairo, Egypt

Mohamed Elalfy

Dr. Mohamed Elalfy is a fellow of the Royal College of Ophthalmologists in London, the Royal College of Surgeons in Edinburgh, the Royal College of Physicians and Surgeons in Glasgow, the European Board of Ophthalmology and the International Council of Ophthalmology. He is an active member of the European Society of Cataract and Refractive Surgery, and of The European Cornea Society and Refractive Surgery. Mr Elalfy travels abroad as an invited guest to share his expertise through teaching and live surgeries. He is Fellowship Programme Director in Corneoplastic Unit, Queen Victoria Hospital where he trains four fellows annually. Having obtained two academic qualifications through his career of more than 15 years in ophthalmology and with more than 30 peer-reviewed publications, Mr Elalfy puts evidence-based ophthalmology in the heart of his practice.

Affiliations and expertise

Ophthalmologist - Private Practice, UK