- eBook ISBN 9780124172180
- Print ISBN 9780124172173
The Exposome: A Primer is the first book dedicated to exposomics, detailing the purpose and scope of this emerging field of study, its practical applications and how it complements a broad range of disciplines. Genetic causes account for up to a third of all complex diseases. (As genomic approaches improve, this is likely to rise.) Environmental factors also influence human disease but, unlike with genetics, there is no standard or systematic way to measure the influence of environmental exposures. The exposome is an emerging concept that hopes to address this, measuring the effects of life-long environmental exposures on health and how these exposures can influence disease.
This systematic introduction considers topics of managing and integrating exposome data (including maps, models, computation, and systems biology), "-omics"-based technologies, and more. Both students and scientists in disciplines including toxicology, environmental health, epidemiology, and public health will benefit from this rigorous yet readable overview.
Chapter 1. The Exposome: Purpose, Definition, and Scope
1.1 Why a Primer?
1.2 What is the Exposome?
1.3 Darwin Would Be Proud
1.4 If it is So Obvious, Why This Book?
1.5 Environmental Health Practitioners
1.6 The Exposome as an Educational Tool
1.7 Discussion Questions
Chapter 2. When the Genome Falls Short: Limitations of a Gene-Centric View of Health
2.1 DNA, No Longer a Secret
2.2 The Gene Versus Environment Continuum
2.3 A Dangerous Metaphor?
2.4 ENCODE Project
2.5 Epigenetics: A Clear Gene–Environment Interface
2.6 Obstacles and Opportunities
2.7 Discussion Questions
Chapter 3. The Explosion of -Omic-Based Technology and its Impact on the Exposome
3.1 The Science of “Me, Too”
3.8 What to Do with All of These -Omes
3.9 What Type of Omic is the Exposome?
3.10 Obstacles and Opportunities
3.11 Discussion Questions
Chapter 4. The Exposome in Environmental Health Sciences and Related Disciplines
4.1 Welcome Home Exposome
4.2 Toxicology—Mechanisms of Toxicity
4.3 Exposure Science (or Assessment, or Biology)
4.4 Epidemiology and the Exposome
4.5 Global Epidemiology
4.6 Pesticides as an Example of Strained Relationships
4.7 Obstacles and Opportunities
4.8 Discussion Questions
Chapter 5. Managing and Integrating Exposome Data: Maps, Models, Computation, and Systems Biology
5.1 Maps, Models, and Technology
5.3 Big Data, Really Big
5.4 I am so Smart, S-M-R-T
"There is some suggestions for teaching the exposome, including an outline syllabus for a short course, and Miller's ideas about how the science might move forward over the next five to ten years… Overall I found this a useful introduction to the exposome and well worth reading if you want to better understand this new developing science." --OH-World.org blog, January 2014