The Epilepsies - 1st Edition - ISBN: 9780124221505, 9780080542454

The Epilepsies

1st Edition

Etiologies and Prevention

Editors: Prakash Kotagal Hans Luders
eBook ISBN: 9780080542454
Imprint: Academic Press
Published Date: 19th October 1998
Page Count: 587


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Tremendous advances in our understanding of epilepsy have occurred in the last two decades. Techniques such as electroencephalography, neuroimaging, neurosurgery and neuropsychology are giving us a better understanding of the pathogenesis of epilepsy. Additionally major breakthroughs are taking place in the laboratories of scientists studying genetics, embryogenesis, neuropathology, neurochemistry and pharmacology. These advances provide a much better understanding of why patients develop epilepsy, reshaping the way in which the epileptic patient is cared for. This book presents the most current information on the various etiologies of epilepsy, their treatments, and their possible prevention. Kotagal and Lüders have assembled 80 internationally known experts to compile this authoritative, comprehensive, and well-rounded work.

The Epilepsies is a one-of-a-kind reference that will be of interest to specialists and basic scientists involved in the study of epilepsy, adult and pediatric neurologists, neurosurgeons, residents and fellows in these areas, and pediatricians who frequently encounter children with neurological problems. This major work brings together the most up-to-date research on the causes of epilepsy and other associated diseases which cause seizures. It presents data on infections, trauma, mesial temporal sclerosis, cerebral dysgenesis, brain tumors, vascular lesions, stroke, as well as genetic, metabolic and toxic causes of epilepsy. The book also looks at drug treatment and new surgical techniques that have proven useful in alleviating epileptic and other related seizures.

Key Features

@introbul:Key Features @bul:* More than 65 chapters are organized into the following sections:

  • Cerebral Dysgenesis
  • Mesial Temporal Sclerosis
  • Postinfectious Epilepsy
  • Posttraumatic Epilepsy
  • Neoplastic Causes of Epilepsy
  • Vascular Causes of Epilepsy
  • Non-Heriditary Myoclonic Epilepsy
  • Metabolic and Toxic Causes of Epilepsy
  • Etiologies of Neonatal Seizures
  • Psychogenic Seizures
  • Genetic Causes of Epilepsy


Graduate students, adult and pediatric neurologists, neurosurgeons, and researchers.

Table of Contents

Causes of Epilepsy:

W.A. Hauser, Risk Factors for Epilepsy.

Cerebral Dysgenesis:

G.L. Holmes, Cerebral Dysgenesis: Overview.

W.B. Dobyns, Experimental Models of Cortical Malformations.

P.M. Ruggieri, MRI Techniques for the Identification of Neuronal Migration Disorders: Practical Considerations.

H.T. Chugani, Role of PET in Detection of Cerebral Dysgenesis.

L.B. Rorke, Pathological Aspects of Cerebral Dysplasia.

D.R. Fish, Localised Cortical Dysgenesis and Epilepsy.

C. Graveline, P. Hwang, T. Fitzpatrick, V. Jay, and H.J. Hoffman, Sturge-Weber Syndrome: Implications of Functional Studies on Neural Plasticity, Brain Maturation, and Timing of Surgical Treatment.

P. Kotagal, Tuberose Sclerosis.

E. Wyllie and W. Dobyns, Epidermal Nevus Syndrome.

H.B. Sarnat and L. Hudgins, Prevention of Neuroblast Migratory Disorders.

O. Çataltepe and Y. Comair, Focal Resection in the Treatment of Neuronal Migrational Disorders.

H. Holthausen, I. Tuxhorn, T. Pieper, H. Pannek, R. Lahl, and F. Oppel, Hemispherectomy in the Treatment of Neuronal Migrational Disorders.

D.W. Roberts, Corpus Callosotomy in the Treatment of Neuronal Migration Disorders.

T. Tanaka, M. Kunimoto, K. Hashizume, Y. Yonemasu, and H.O. Lüders, Multiple Subpial Transection in the Treatment of Neuronal Migration Disorders: Basic and Clinical Approaches.

Mesial Temporal Sclerosis:

H.O. Lüders, Overview.

A.S. Harvey, The Role of Febrile Convulsions in Mesial Temporal Sclerosis.

H.K. Wolf and I. Blümcke, Pathological Findings in Mesial Temporal Sclerosis.

P. Kotagal, Seizure Semiology of Mesial Temporal Lobe Epilepsy.

G.W. Mathern, Hippocampal Pathophysiology in Experimental Models.

T.L. Babb, Hippocampal Neurophysiology in Humans.

C.L. Wilson, Neurophysiology of Epileptic Limbic Pathways in Intact Human Temporal Lobe.

D.W. Loring and K.J. Meador, Usefulness of the Wada Test in Mesial Temporal Lobe Epilepsy.

M. Hoppe, H. Baier, and A. Ebner, Noninvasive Electroencephalography and Mesial Temporal Sclerosis.

J. Ross, G.R. Cosgrove, and A.J. Cole, Invasive EEG in Mesial Temporal Epilepsy.

G.J. Chelune and W. Loken, Mesial Temporal Sclerosis and Memory Functions.

A.E. Thornton and R.I. Naugle, The Utility of Neuropsycholigical Evaluation in Mesial Temporal Sclerosis: Differential Memory Performance Based on Seizure Laterality.

C.R. Jack, Jr., Hippocampal Volumetry in Mesial Temporal Sclerosis.

T.C. Ng, Y. Comair, and E. Geller, Proton MRS for the Evaluation of Temporal Lobe Epilepsies.

S. Raja, Functional Neuroimaging with PET and SPECT in Temporal Lobe Epilepsy.

D.D. Spencer, The Surgical Treatment of Temporal Lobe Epilepsy.

Postinfectious Epilepsy:

L.E. Davis and J.J. Shih, CNS Infections and Epilepsy.

A. Sakamoto, V.C.T. Bustamante, E. Garzon, O.M. Takayanagui, A.C. Santos, R.M.F. Fernandes, J.P. Leite, L.M.C. Chimelli, and J.A. Assirati, Jr., Cysticercosis and Epilepsy.

E.P.G. Vining, Rasmussen's Syndrome.

Posttraumatic Epilepsy:

L.J. Willmore, How Does Trauma Cause Epilepsy?

A.M. Salazar and R. Ellenbogen, Posttraumatic Epilepsy Prevention.

Neoplastic Causes of Epilepsy:

H.H. Morris III, Overview.

D.R. Fish, How Do Tumors Cause Epilepsy?

E.C. Bourekas and J. Perl II, Imaging of Tumors in Epilepsy.

R.A. Prayson and M.L. Estes, Dysembryoplastic Neuroepithelial Tumor, Ganglioglioma, and Hamartoma: Are They Distinct Entitities?

N.J. Kazemi and G.D. Cascino, The Double Lesion: Dual Pathology and Pathological Correlation.

F. Morrell and L. de Toledo-Morrell, Secondary Epileptogenesis and Brain Tumors.

O. Çataltepe and Y. Comair, Strategies in Operating on Patients with Tumor-Related Epilepsy.

Vascular Causes of Epilepsy:

K.P. Vives and I.A. Awad, Overview.

D.L.A. Kraemer and J.H. Pizzonia, Vascular Lesions as a Cause of Epilepsy P.C. Van Ness, Pros and Cons of Lesionectomy as Treatment for Partial Epilepsy.

M.E. Lancman, Stroke-Related Epilepsy.

I. Anand and D.S. Dinner, Epilepsy in Immunological Disorders. Nonhereditary Myoclonic Epilepsy:

H. Shibasaki, Overview.

J.C. Rothwell, P. Brown, and K. Werhahn, Posthypoxic Action Myoclonus.

Metabolic and Toxic Causes of Epilepsy:

J.C.M. Brust, Seizures and Commonly Prescribed Drugs.

H.W. Moser, Peroxisomal Disorders.

J. Aicardi, Pyridoxine-Responsive Epilepsy.

J.C.M. Brust, Seizures, Ethanol, and Recreationally Abused Drugs.

C. Sansaricq, G. Lyon, and E.H. Kolodny, Seizures in Hereditary Metabolic Disease: Evaluation of Suspected Hereditary Metabolic Disease in the Etiology of Seizures.

Neonatal Seizures:

S. Kotagal, Overview.

A. Hill, Hypoxic-Ischemic Encephalopathy in the Newborn.

S. Kotagal, Neonatal Cerebral Infarction.

S.G. Kahler, Neonatal Metabolic Disorders.

M.W. Kline, Infectious Causes of Neonatal Seizures.

Psychogenic Seizures:

S.J. Stagno, Overview.

S.J. Stagno, Etiologic Factors in Psychogenic Seizures.

A.M. Kanner and J. Iriarte, Psychogenic Pseudoseizures: Semiology and Differential Diagnosis.

T. Betts, Treatment of Nonepileptic Seizures.

Genetic Causes of Epilepsy:

T.N. Seyfried and M. Todorova, Experimental Models of Epilepsy.

L.J. Treiman and D.M. Treiman, Genetic Epilepsies--Generalized.

A. Lehesjoki, Progressive Myoclonus Epilepsies.

D. Janz and T. Sander, Juvenile Myoclonic Epilepsy: The Complexity of a Simple Syndrome. Index.


No. of pages:
© Academic Press 1998
Academic Press
eBook ISBN:

About the Editor

Prakash Kotagal

Affiliations and Expertise

The Cleveland Clinic Foundation, Ohio, U.S.A.

Hans Luders

Affiliations and Expertise

The Cleveland Clinic Foundation, Cleveland, Ohio, U.S.A.