The Epidemiology of Plasmodium vivax: History, Hiatus and Hubris, Part B

The Epidemiology of Plasmodium vivax: History, Hiatus and Hubris, Part B

1st Edition - January 31, 2013

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  • Editors: S.I. Hay, Ric Price, J. Kevin Baird
  • eBook ISBN: 9780124078772

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First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. Advances in Parasitology includes medical studies on parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications. Eclectic volumes are supplemented by thematic volumes on various topics, including control of human parasitic diseases and global mapping of infectious diseases.

Key Features

  • Informs and updates on all the latest developments in the field
  • Contributions from leading authorities and industry experts


Researchers in parasitology, tropical medicine and entomology

Table of Contents

  • Series Editors



    Chapter One. Plasmodium vivax

    1. Introduction

    2. The General Life Cycle of Plasmodium vivax and Other Primate Malaria Parasite Species

    3. In Vitro and Ex Vivo Models for Examining P. vivax Biology

    4. Neotropical Non-Human Primate Models (New World Monkeys) for Investigating the Varied Biology of vivax Malaria

    5. The Relapsing Malaria Parasites of Southern Asian Macaque Monkeys as Models for P. vivax Biology

    6. From Genomics to Systems Biology: The Bigger Picture Puzzles

    7. Conclusions

    8. Acknowledgements


    Chapter Two. Red Blood Cell Polymorphism and Susceptibility to Plasmodium vivax

    1. Introduction

    2. The Era of Great Biological Discovery

    3. Resistance to P. vivax and Insights On Malaria Red Cell Invasion

    4. Evolving Perspectives on Resistance to P. vivax

    5. Conclusions and Future Directions

    6. Acknowledgements


    Chapter Three. Natural Acquisition of Immunity to Plasmodium vivax

    1. Overview of Naturally Acquired Immunity to Malaria

    2. Differential Acquisition of Immunity to P. vivax and P. falciparum Under Natural Exposure

    3. Acquisition of Immunity in Experimental Infections – Lessons from Malaria Therapy Patients and Irradiated Sporozoites

    4. Unique Biological Characteristics of P. vivax that Contribute to NAI

    5. Effector Mechanisms for Blood-Stage Immunity

    6. Targets of Blood-Stage Immunity

    7. Immune Responses to Malaria Pre-Erythrocytic Stages

    8. Sexual Stage Parasites and Transmission-Blocking Immunity

    9. Conclusions

    10. Future Directions


    Chapter Four. G6PD Deficiency

    1. Introduction

    2. Historical Overview

    3. Glucose-6-Phosphate Dehydrogenase Deficiency: The Enzyme and Its Gene

    4. Diagnosing G6PD Deficiency

    5. Mapping the Spatial Distribution of G6PD Deficiency

    6. Spatial Co-occurrence of G6PD Deficiency with P. vivax Endemicity

    7. Evolutionary Drivers of the Distribution of G6PD Deficiency

    8. Primaquine, P. vivax and G6PD Deficiency

    9. Towards a Risk Framework for P. vivax Relapse Treatment

    10. Conclusions

    11. Acknowledgements


    Chapter Five. Genomics, Population Genetics and Evolutionary History of Plasmodium vivax

    1. The Importance of Studying Plasmodium Diversity

    2. The Evolutionary History of P. vivax

    3. The P. vivax Genome and Comparative Genomics

    4. P. vivax Global Genetic Diversity and Population Structure

    5. P. vivax Population Genetics in India

    6. Conclusion

    7. Acknowledgements


    Chapter Six. Malariotherapy – Insanity at the Service of Malariology

    1. Introduction

    2. The Era of Malariotherapy

    3. The Practice of Malariotherapy

    4. Malariotherapy and Malariology

    5. Malariotherapy’s Major Contributions to Malariology

    6. Lessons from Malariotherapy: Caveats and Current Relevance

    7. Conclusions



Product details

  • No. of pages: 304
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: January 31, 2013
  • Imprint: Academic Press
  • eBook ISBN: 9780124078772

About the Serial Volume Editors

S.I. Hay

Affiliations and Expertise

Professor of Epidemiology, Spatial Epidemiology and Ecology Group, Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, U.K.

Ric Price

J. Kevin Baird

About the Serial Editor

D. Rollinson

D. Rollinson
Professor David Rollinson is a Merit Research Scientist at the Natural History Museum in London, where he leads a research team in the Wolfson Wellcome Biomedical Laboratories and directs the WHO Collaborating Centre for schistosomiasis. He has had a long fascination with parasites and the diseases that they cause, this has involved him in many overseas projects especially in Africa. He is on the WHO Expert Advisory Panel of parasitic diseases, the editor of Advances in Parasitology and a former President of the World Federation of Parasitologists. His research group uses a multidisciplinary approach, which combines detailed molecular studies in the laboratory with ongoing collaborative studies in endemic areas of disease, to explore the intriguing world of parasites in order to help control and eliminate parasitic diseases.

Affiliations and Expertise

Merit Research Scientist, The Natural History Museum, London, UK

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