The Enzymes - 1st Edition - ISBN: 9780121227258, 9780080460420

The Enzymes, Volume 24

1st Edition

Protein Methyltransferases

Editors: Fuyuhiko Tamanoi Steven Clarke
eBook ISBN: 9780080460420
Hardcover ISBN: 9780121227258
Imprint: Academic Press
Published Date: 19th June 2006
Page Count: 592
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Table of Contents

The Enzymes, Volume 24 Table of Contents Protein methyltransferases

Part I: Overview of Protein Methyltransferases

  1. Protein methyltransferases: Their distribution among the five structural classes of AdoMet-dependent methyltransferases

Part II: Modification of Lysine and Arginine Residues in Signal Transduction, Transcription Translation, and Other Functions

  1. The family of protein arginine methyltransferases
  2. Diverse roles of protein arginine methyltransferases
  3. Structure of protein arginine methyltransferases
  4. Methylation and demethylation of histone Arg and Lys residues in chromatin structure and function
  5. Structure of SET domain protein lysine methyltransferases
  6. Non-histone protein lysine methyltransferases - structure and catalytic roles
  7. Demethylation pathways for histone methyllysine residues

Part III: Biological Regulation by Protein Methyl Ester Formation

  1. Structure and function of isoprenylcysteine carboxylmethyltransferase (Icmt), a key enzyme in CaaX processing
  2. Genetic approaches for understanding the physiologic importance of the carboxyl methylation of isoprenylated proteins
  3. Reversible methylation of protein phosphatase 2A
  4. Reversible methylation of glutamate residues in the receptor proteins of bacterial sensory systems

Part IV: Recognition of Damaged Proteins in Aging by Protein Methyltransferases

  1. Protein L-isoaspartyl, D-aspartyl O-methyltransferases: catalysts for protein repair

Part V: Modification of Proteins by Methylation of Glutamine and Asparagine Residues

  1. Modification of glutamine residues in proteins involved in translation
  2. Modification of phycobiliproteins at asparagine residues

Part VI: Inhibition of Metyltransferases by Metabolites

  1. Inhibition of mammalian protein methyltransferases by 5'-methylthioadenosine (MTA): A mechanism of action of dietary SAMe?


Protein methylation has recently emerged as one of the most exciting areas of study on posttranslational modification. A large family of protein methyltransferases has been identified and their structural properties have been characterized. These studies have provided novel insights into how methylation regulates a variety of biological functions including DNA and RNA metabolism, protein synthesis and signal transduction. Methylation also plays important roles in aging. This volume is intended to capture these recent developments concerning protein methyltransferases.


Biochemists, cell biologists, molecular biologists, biophysicists, and microbiologists


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Ratings and Reviews

About the Editors

Fuyuhiko Tamanoi Editor

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997. Since 1996, he has been a Director of Signal Transduction Program Area at Jonsson Comprehensive Cancer Center. Dr. Tamanoi earned his B.S. and M.S. in Biochemistry at the University of Tokyo. He received PhD in Molecular Biology at Nagoya University in 1977. He was a postdoctoral fellow at Harvard Medical School, where he worked on bacteriophage DNA replication. From 1980 to 1985, he was a senior staff investigator at Cold Spring Harbor Laboratory, where he worked on adenovirus DNA replication. From 1985 to 1993, he was an Assistant Professor and then Associate Professor at the University of Chicago, where he initiated studies on lipid modification of the Ras family proteins. His laboratory research centers on signal transduction and signal transduction inhibitors. He is currently exploring ways to deliver signal transduction inhibitors using nanoparticles.

Affiliations and Expertise

Professor and Vice Chair, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles and Director, Signal Transduction Program Area, Jonsson Comprehensive Cancer Center, USA

Steven Clarke Editor

Affiliations and Expertise

Department of Chemistry and Biochemistry, University of California Los Angeles, USA