Description

Protein methylation has recently emerged as one of the most exciting areas of study on posttranslational modification. A large family of protein methyltransferases has been identified and their structural properties have been characterized. These studies have provided novel insights into how methylation regulates a variety of biological functions including DNA and RNA metabolism, protein synthesis and signal transduction. Methylation also plays important roles in aging. This volume is intended to capture these recent developments concerning protein methyltransferases.

Readership

Biochemists, cell biologists, molecular biologists, biophysicists, and microbiologists

Table of Contents

The Enzymes, Volume 24 Table of Contents Protein methyltransferases Part I: Overview of Protein Methyltransferases 1. Protein methyltransferases: Their distribution among the five structural classes of AdoMet-dependent methyltransferases Part II: Modification of Lysine and Arginine Residues in Signal Transduction, Transcription Translation, and Other Functions 2. The family of protein arginine methyltransferases 3. Diverse roles of protein arginine methyltransferases 4. Structure of protein arginine methyltransferases 5. Methylation and demethylation of histone Arg and Lys residues in chromatin structure and function 6. Structure of SET domain protein lysine methyltransferases 7. Non-histone protein lysine methyltransferases - structure and catalytic roles 8. Demethylation pathways for histone methyllysine residues Part III: Biological Regulation by Protein Methyl Ester Formation 9. Structure and function of isoprenylcysteine carboxylmethyltransferase (Icmt), a key enzyme in CaaX processing 10. Genetic approaches for understanding the physiologic importance of the carboxyl methylation of isoprenylated proteins 11. Reversible methylation of protein phosphatase 2A 12. Reversible methylation of glutamate residues in the receptor proteins of bacterial sensory systems Part IV: Recognition of Damaged Proteins in Aging by Protein Methyltransferases 13. Protein L-isoaspartyl, D-aspartyl O-methyltransferases: catalysts for protein repair Part V: Modification of Proteins by Methylation of Glutamine and Asparagine Residues 14. Modification of glutami

Details

No. of pages:
592
Language:
English
Copyright:
© 2006
Published:
Imprint:
Academic Press
Electronic ISBN:
9780080460420
Print ISBN:
9780121227258

About the editors

Fuyuhiko Tamanoi

Professor Fuyu Tamanoi works at the Dept. of Microbiology, Immunology and Molecular Genetics at the University of California.