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The Enzymes - 1st Edition - ISBN: 9780121227258, 9780080460420

The Enzymes, Volume 24

1st Edition

Protein Methyltransferases

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Editors: Fuyuhiko Tamanoi Steven Clarke
Hardcover ISBN: 9780121227258
eBook ISBN: 9780080460420
Imprint: Academic Press
Published Date: 19th June 2006
Page Count: 592
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Table of Contents

The Enzymes, Volume 24 Table of Contents Protein methyltransferases

Part I: Overview of Protein Methyltransferases

  1. Protein methyltransferases: Their distribution among the five structural classes of AdoMet-dependent methyltransferases

Part II: Modification of Lysine and Arginine Residues in Signal Transduction, Transcription Translation, and Other Functions

  1. The family of protein arginine methyltransferases
  2. Diverse roles of protein arginine methyltransferases
  3. Structure of protein arginine methyltransferases
  4. Methylation and demethylation of histone Arg and Lys residues in chromatin structure and function
  5. Structure of SET domain protein lysine methyltransferases
  6. Non-histone protein lysine methyltransferases - structure and catalytic roles
  7. Demethylation pathways for histone methyllysine residues

Part III: Biological Regulation by Protein Methyl Ester Formation

  1. Structure and function of isoprenylcysteine carboxylmethyltransferase (Icmt), a key enzyme in CaaX processing
  2. Genetic approaches for understanding the physiologic importance of the carboxyl methylation of isoprenylated proteins
  3. Reversible methylation of protein phosphatase 2A
  4. Reversible methylation of glutamate residues in the receptor proteins of bacterial sensory systems

Part IV: Recognition of Damaged Proteins in Aging by Protein Methyltransferases

  1. Protein L-isoaspartyl, D-aspartyl O-methyltransferases: catalysts for protein repair

Part V: Modification of Proteins by Methylation of Glutamine and Asparagine Residues

  1. Modification of glutamine residues in proteins involved in translation
  2. Modification of phycobiliproteins at asparagine residues

Part VI: Inhibition of Metyltransferases by Metabolites

  1. Inhibition of mammalian protein methyltransferases by 5'-methylthioadenosine (MTA): A mechanism of action of dietary SAMe?


Protein methylation has recently emerged as one of the most exciting areas of study on posttranslational modification. A large family of protein methyltransferases has been identified and their structural properties have been characterized. These studies have provided novel insights into how methylation regulates a variety of biological functions including DNA and RNA metabolism, protein synthesis and signal transduction. Methylation also plays important roles in aging. This volume is intended to capture these recent developments concerning protein methyltransferases.


Biochemists, cell biologists, molecular biologists, biophysicists, and microbiologists


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© Academic Press 2006
19th June 2006
Academic Press
Hardcover ISBN:
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About the Editors

Fuyuhiko Tamanoi

Affiliations and Expertise

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USA

Steven Clarke

Affiliations and Expertise

Department of Chemistry and Biochemistry, University of California Los Angeles, USA