The Enzymes

The Enzymes

Protein Methyltransferases

1st Edition - June 19, 2006

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  • Editors: Fuyuhiko Tamanoi, Steven Clarke
  • Hardcover ISBN: 9780121227258
  • eBook ISBN: 9780080460420

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Protein methylation has recently emerged as one of the most exciting areas of study on posttranslational modification. A large family of protein methyltransferases has been identified and their structural properties have been characterized. These studies have provided novel insights into how methylation regulates a variety of biological functions including DNA and RNA metabolism, protein synthesis and signal transduction. Methylation also plays important roles in aging. This volume is intended to capture these recent developments concerning protein methyltransferases.


Biochemists, cell biologists, molecular biologists, biophysicists, and microbiologists

Table of Contents

  • The Enzymes, Volume 24 Table of Contents
    Protein methyltransferases

    Part I: Overview of Protein Methyltransferases

    1. Protein methyltransferases: Their distribution among the five structural classes of AdoMet-dependent methyltransferases

    Part II: Modification of Lysine and Arginine Residues in Signal Transduction, Transcription Translation, and Other Functions

    2. The family of protein arginine methyltransferases
    3. Diverse roles of protein arginine methyltransferases
    4. Structure of protein arginine methyltransferases
    5. Methylation and demethylation of histone Arg and Lys residues in chromatin structure and function
    6. Structure of SET domain protein lysine methyltransferases
    7. Non-histone protein lysine methyltransferases - structure and catalytic roles
    8. Demethylation pathways for histone methyllysine residues

    Part III: Biological Regulation by Protein Methyl Ester Formation

    9. Structure and function of isoprenylcysteine carboxylmethyltransferase (Icmt), a key enzyme in CaaX processing
    10. Genetic approaches for understanding the physiologic importance of the carboxyl methylation of isoprenylated proteins
    11. Reversible methylation of protein phosphatase 2A
    12. Reversible methylation of glutamate residues in the receptor proteins of bacterial sensory systems

    Part IV: Recognition of Damaged Proteins in Aging by Protein Methyltransferases

    13. Protein L-isoaspartyl, D-aspartyl O-methyltransferases:
    catalysts for protein repair

    Part V: Modification of Proteins by Methylation of Glutamine and Asparagine Residues

    14. Modification of glutamine residues in proteins involved in translation
    15. Modification of phycobiliproteins at asparagine residues

    Part VI: Inhibition of Metyltransferases by Metabolites

    16. Inhibition of mammalian protein methyltransferases by 5'-methylthioadenosine (MTA): A mechanism of action of dietary SAMe?

Product details

  • No. of pages: 592
  • Language: English
  • Copyright: © Academic Press 2006
  • Published: June 19, 2006
  • Imprint: Academic Press
  • Hardcover ISBN: 9780121227258
  • eBook ISBN: 9780080460420

About the Editors

Fuyuhiko Tamanoi

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.

Affiliations and Expertise

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USA

Steven Clarke

Affiliations and Expertise

Department of Chemistry and Biochemistry, University of California Los Angeles, USA

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