The Encyclopedia of Mass Spectrometry

The Encyclopedia of Mass Spectrometry

Volume 2: Biological Applications Part A

1st Edition - September 27, 2004

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  • Editors: Richard M. Caprioli, Michael L. Gross
  • Hardcover ISBN: 9780080438009

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The focus of Volume 2 of the Encyclopedia of Mass Spectrometry is on peptides and proteins, separation techniques, preparation protocols, and the fundamental characteristics as ionic gas phase species that lie within the breadth of the field of mass spectrometry. This volume is divided into four sections; experimental approaches and protocols, sequence analysis, other structural analyses, and targeted applications.

Key Features

  • Frontier Research on biological, biochemical, and biomedical applications of MS
  • Focus on Peptides and Proteins
  • Suitable for new graduate students entering the field


Advanced Research Scientists; Mass Spectrometrists; Spectroscopists; Analytical Chemists; and those working in these fields.

Table of Contents

  • CE/MS, analysis by (A. Moseley).

    Chemical modification/damage (Steve Barnes).

    Derivatization for Analysis (B. Griffiths).

    Desalting/purification/microdialysis (Terry Lee).

    Disulfide Bond Analysis (Watson).

    Enzyme kinetics (Dan Farbris).

    Folding/Unfolding (D. Smith).

    Fragmentation Mechanisms of Ions (Wesdemiotis).

    Gel Electrophoresis (R. Loo).

    Glycoproteins (J Peter Katalinic).

    H/D Exchange Methods (D. Smith).

    High-resolution Measurements by FTMS (Troy Wood).

    High Sensitivity Detection (G. Valaskovic).

    Hydrolysis, Chemical & Enzymatics (Eckard Nordhoff).

    Image Analysis of Proteins in Tissues (Caprioli/Chaurand).

    Protein Complexes (A. Link).


    Membrane proteins (Falick).

    Metal Ion Binding (Baldwin).

    Molecular Weight Measurements (Kondrat).

    Neuropeptides (Nyberg).

    Non-covalent Interactions, Ligand/Protein (Loo).

    Non-covalent Interactions, Protein/Protein (Heck).

    Phosphorylation, sulfation.

    Proteomics (Jim Carroll).


    Quaternary Structure (Terry Farmer).

    Secondary Structure.

    Sequence Analysis - Digestion/Cleavage (Grant).

    Sequence Analysis - High Energy MS/MS (Papayannopoulos).

    Sequence Analysis - Low Energy MS/MS (Shabanowitz/Hunt).

    Sequence Analysis - PSD with MALDI (Chaurand/Spengler).

    Single Cell, analysis of (Sweedler).

Product details

  • No. of pages: 400
  • Language: English
  • Copyright: © Elsevier Science 2004
  • Published: September 27, 2004
  • Imprint: Elsevier Science
  • Hardcover ISBN: 9780080438009

About the Editors

Richard M. Caprioli

Biography Richard M. Caprioli is the Stanley Cohen Professor of Biochemistry and Director of the Mass Spectrometry Research Center at Vanderbilt University School of Medicine. He is also currently Professor in the Departments of Chemistry and Pharmacology at Vanderbilt.

Affiliations and Expertise

Vanderbilt University School of Medicine, Nashville, USA

Michael L. Gross

Michael L. Gross is Professor of Chemistry and Professor of Medicine at Washington University, St. Louis, as well as Director of the NIH Mass Spectrometry Research Resource located at Washington University.

1966: Ph.D., University of Minnesota
1987: Commonwealth of Massachusetts Pioneer Award, "In Search of the Health Consequences of Dioxin in Our Environment"
1983 -1991: Identified as one of the 50 most cited chemists
1999: Field and Franklin Award of The American Chemical Society
2001: Outstanding Graduate Student Mentor, Washington University

Affiliations and Expertise

Washington University, St Louis, USA

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