The Emergency of Order in Developing Systems

Contributors and Presiding Chairmen

Bibliography of Viktor Hamburger

The Emergence of Order in Developing Systems

I. Self-Assembly of Macromolecular Structures

Spontaneous Formation of the Three-Dimensional Structure of Proteins

Introduction

Function and Geometry

Effects of Interruption or Modification of Genetic Information

Summary

References

Self-Association Reactions among Fibrous Proteins: The Myosin ⇌ Polymer System

Introduction

The Structure of the Thick Filament

Self-Association Reactions of Myosin Molecules

The Effect of Salt Concentration and pH on the Myosin ⇌ Polymer Equilibrium Constant

Temperature Dependence of the Equilibrium Constant

Effect of Pressure on the Equilibrium Constant

Discussion

References

II Ordering of Subcellular Units

The Assembly of Microtubules and Their Role in the Development of Cell Form

Introduction

Evidence Relating Microtubules to the Development of Cell Form

Control of Microtubule Pattern—Factors That Order the Distribution of Microtubules in Cells

Summary and Conclusion

References

The Biochemical Organization of Cytoplasmic Membranes

Introduction

Model Phospholipid-Hydrocarbon Films

Synthesis and Organization of the Lipopolysaccharide of the Inner and Outer Membranes of the Salmonella Cell Envelope

Structure of Mitochondrial Membranes

Conclusion

References

The Emergence of Pattern in the Cell Walls of Higher Plants

Introduction

Types of Patterning in Plant Cell Walls

The Cytoplasm-Wall Interface

Cytoplasmic Structures Associated with Wall Patterning: The Microtubule

Cytoplasmic Streaming and Wall Patterning

Cytoplasmic Structures Associated with Wall Patterning: Membranes

Conspectus

References

III. Emergence of Order in Tissues and Organs

Communication through Cell Junctions. Implications in Growth Control and Differentiation

Physico-Chemical Aspects

Developmental Aspects

References

Morphogenetic Phases in Development

Introduction

Early Chondroitin Sulfate Synthesis

Morphogenetic Activities

Cell Sorting Based on Morphogenetic Properties

Comparison of Limb and Somite Mesoderms

Temporal Relations

Relation between Morphogenesis and Histogenesis

References

Emergence of Form and Function in the Embryonic Heart

Introduction

Mapping the Precardiac Mesoderm

The Initiation of Function

The Properties of Heart Cells in Culture

Spontaneous Activity of Cultured Cells

References

IV. Emergence of Nervous Coordination

Origins of Integrated Behavior

Beginnings of Functional Activity

Spontaneous Motility in Embryos

Origins of Integrated Behavior

The Role of Sensory Input in the Development of Integrated Behavior

Concluding Remarks

References

Order and Control in Neurogenesis (As Exemplified by the Lateral Motor Column)

Introduction

Periphero-Central Relationships: Chick

Lateral Motor Column Development in Anurans

Motor Cell-Nerve Fiber Number Relationships

Intrinsic Differentiation Capacities of the Lateral Motor Column

Thyroid Hormone Effects on the Lateral Motor Column

Influence of Temperature

Periphero-Central Relationships: Anurans

Degeneration in the Lateral Motor Column

Cell Migration into the Already Established Lateral Motor Column

Cytodifferentiation in the Lateral Motor Column

Temporary Maintenance of Excessive Cell Numbers following Limb Amputation

Resumé of Modes of Adjusting Cell Numbers

Concluding Remarks

References

Plasticity of Neural Maturation

Introduction

Agenesis of Corpus Callosum: A Symptomatic Case

Hemispheric Deconnection Syndrome

Surgical-Congenital Differences

Developmental Compensation: Generalized Phenomenon

Possible Explanatory Factors

References

Author Index

Subject Index