The Emergency of Order in Developing Systems - 1st Edition - ISBN: 9780123957115, 9780323153249

The Emergency of Order in Developing Systems

1st Edition

Editors: Michael Locke
eBook ISBN: 9780323153249
Imprint: Academic Press
Published Date: 1st January 1968
Page Count: 378
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The Emergence of Order in Developing Systems is a collection of papers presented at the 27th Symposium of the Society for Developmental Biology, held in Ithaca, New York in June 1968. Contributors focus on the emergence of orderly patterns during development, touching on topics ranging from the three-dimensional structure of the protein molecule to the polymerization of structural units, the self-assembly of microtubules in axonemes, and the patterning of plant cell walls.
This volume is organized into four sections encompassing 11 chapters and begins with an overview of the emergence of order during cellular differentiation and growth, paying particular attention to the spontaneous formation of the three-dimensional structure of proteins. The next chapters explore self-association reactions in solutions of myosin molecules; ordering of subcellular units; factors that order the distribution of microtubules and thus ultimately pattern the shape of the cell; the biochemical organization of cytoplasmic membranes through self-assembly; and patterning in cell walls of higher plants. The book also explains the emergence of order in tissues and organs, and then concludes with a discussion on the emergence of order on the behavioral level.
This book will be of interest to developmental biologists and embryologists.

Table of Contents

Contributors and Presiding Chairmen

Bibliography of Viktor Hamburger

The Emergence of Order in Developing Systems

I. Self-Assembly of Macromolecular Structures

Spontaneous Formation of the Three-Dimensional Structure of Proteins


Function and Geometry

Effects of Interruption or Modification of Genetic Information



Self-Association Reactions among Fibrous Proteins: The Myosin ⇌ Polymer System


The Structure of the Thick Filament

Self-Association Reactions of Myosin Molecules

The Effect of Salt Concentration and pH on the Myosin ⇌ Polymer Equilibrium Constant

Temperature Dependence of the Equilibrium Constant

Effect of Pressure on the Equilibrium Constant



II Ordering of Subcellular Units

The Assembly of Microtubules and Their Role in the Development of Cell Form


Evidence Relating Microtubules to the Development of Cell Form

Control of Microtubule Pattern—Factors That Order the Distribution of Microtubules in Cells

Summary and Conclusion


The Biochemical Organization of Cytoplasmic Membranes


Model Phospholipid-Hydrocarbon Films

Synthesis and Organization of the Lipopolysaccharide of the Inner and Outer Membranes of the Salmonella Cell Envelope

Structure of Mitochondrial Membranes



The Emergence of Pattern in the Cell Walls of Higher Plants


Types of Patterning in Plant Cell Walls

The Cytoplasm-Wall Interface

Cytoplasmic Structures Associated with Wall Patterning: The Microtubule

Cytoplasmic Streaming and Wall Patterning

Cytoplasmic Structures Associated with Wall Patterning: Membranes



III. Emergence of Order in Tissues and Organs

Communication through Cell Junctions. Implications in Growth Control and Differentiation

Physico-Chemical Aspects

Developmental Aspects


Morphogenetic Phases in Development


Early Chondroitin Sulfate Synthesis

Morphogenetic Activities

Cell Sorting Based on Morphogenetic Properties

Comparison of Limb and Somite Mesoderms

Temporal Relations

Relation between Morphogenesis and Histogenesis


Emergence of Form and Function in the Embryonic Heart


Mapping the Precardiac Mesoderm

The Initiation of Function

The Properties of Heart Cells in Culture

Spontaneous Activity of Cultured Cells


IV. Emergence of Nervous Coordination

Origins of Integrated Behavior

Beginnings of Functional Activity

Spontaneous Motility in Embryos

Origins of Integrated Behavior

The Role of Sensory Input in the Development of Integrated Behavior

Concluding Remarks


Order and Control in Neurogenesis (As Exemplified by the Lateral Motor Column)


Periphero-Central Relationships: Chick

Lateral Motor Column Development in Anurans

Motor Cell-Nerve Fiber Number Relationships

Intrinsic Differentiation Capacities of the Lateral Motor Column

Thyroid Hormone Effects on the Lateral Motor Column

Influence of Temperature

Periphero-Central Relationships: Anurans

Degeneration in the Lateral Motor Column

Cell Migration into the Already Established Lateral Motor Column

Cytodifferentiation in the Lateral Motor Column

Temporary Maintenance of Excessive Cell Numbers following Limb Amputation

Resumé of Modes of Adjusting Cell Numbers

Concluding Remarks


Plasticity of Neural Maturation


Agenesis of Corpus Callosum: A Symptomatic Case

Hemispheric Deconnection Syndrome

Surgical-Congenital Differences

Developmental Compensation: Generalized Phenomenon

Possible Explanatory Factors


Author Index

Subject Index


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© Academic Press 1968
Academic Press
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About the Editor

Michael Locke

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