The enormity of the literature on growth factors, plus the breadth of the biological disciplines and technical expertise required prohibits a comprehensive review by even a multi-disciplinary panel of authors. To provide an alternative that is feasible for authors and digestible by readers, this review compendium consists of a collection of articles, each covering an aspect of teh ErbB/EGF field. This compilation features articles on growth factor ligands, neuregulins, and individual receptors. The second part of the book concentrates on the biological context of the ErbB receptors, particularly in mammary development and in cancer. It concludes with a discussion of the genetic systems that have enabled significant advances in research in this area.


Cancer researchers, oncologists, cell biologists, pharmacologists, neurologists, and biochemists.

Table of Contents

Introduction EGF Receptor Ligands Neuregulins: Functions, Forms, and Signaling Strategies Epidermal Growth Factor Receptor: Mechanisms of Activation and Signaling The Deaf and Dumb: The Biology of ErbB-2 and ErbB-3 ErbB-4: Mechanism of Action and Biology Trafficking of the ErbB Receptors and Its Influence on Signaling Erbbs in Mammary Development The ErbB Receptors and their Role in Cancer Progression Ligand-Independent Oncogenic Signaling by the Epidermal Growth Factor Receptor: V-ErbB as a Paradigm ErbB-Targeted Therapeutic Approaches in Human Cancer Mechanism of Action of erbB Tyrosine Kinase Inhibitors Signaling by the Drosophila Epidermal Growth Factor Receptor Pathway during Development The Epidermal Growth Factor System in Caenorhabaditis Elegans


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© 2003
Academic Press
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