The Development Of Dictyostelium Discoideum
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The Development Of Dictyostelium Discoideum

1st Edition - January 28, 1982

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  • Editor: William Loomis
  • eBook ISBN: 9780323145664

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Description

The Development of Dictyostelium discoideum consists of 11 chapters representing the 11 major aspects at which continuous progress are made in the study of Dictyostelium discoideum. This book begins with the discovery, classification, ecology, and development of Dictyostelium discoideum. It then outlines the advances in genetic manipulation and mutant isolation of the organism. Much of the advances in cell biology have been related to a better understanding of the composition and function of the cell membrane. Hence, analyses of Dictyostelium plasma membranes are collated. This reference material also describes the role of chemoattractants in organizing cell movements and the intracellular events triggered by occupancy of chemoreceptors. It also explains the understanding of the macromolecular components of the chemosensory system of Dictyostelium discoideum. It further discusses the cell motility, cell adhesion, morphogenetic signaling, cytodifferentiation, and gene expression in the species. Finally, the phenomenon of cell-type specification and regulation in this organism is addressed. This book will be valuable for those already familiar with the general outlines of Dictyostelium biology.

Table of Contents


  • Contributors

    Preface

    1. Comparative Biology of Cellular Slime Molds

    I. Historical

    II. The Life History

    III. Classification

    IV. Ecology

    V. Development

    References

    2. Genetics

    I. Introduction

    II. Chromosomes

    III. Genetic Analysis Using the Parasexual Cycle

    IV. The Macrocyst Cycle

    References

    3. Membranes

    I. Introduction

    II. Membrane Function

    III. Membrane Ultrastructure

    IV. Isolation of Membranes

    V. Composition of Membranes

    VI. Extracellular Material

    VII. Concluding Remarks

    References

    4. Chemotaxis

    I. Introduction

    II. Analysis of Early Aggregation

    III. Chemosensory Transduction

    IV. Molecular Components of the Chemosensory System

    V. Role of the Chemotactic Signal in Early Development

    VI. Working Model of Early Aggregation

    References

    5. Cell Motility

    I. Introduction and Perspectives

    II. Directed Cell Movement Involves Selective Pseudopod Formation

    III. Actin and Myosin Are Primary Components of a Filamentous Matrix That Underlies the Cell Membrane

    IV. Actin and Myosin Are Involved in Ca2+-Dependent Contractions and Gelation — Solation Phenomena

    V. Dictyostelium Actin

    VI. Dictyostelium Myosin

    VII. The Interaction of Actin and Myosin May Be Controlled by Ca2+

    VIII. Concluding Remarks

    References

    6. Cell Adhesion

    I. Introduction

    II. Descriptive Studies Consistent with Selective Cell — Cell Adhesion

    III. Quantitative Assay of Cell — Cell Adhesion

    IV. The Immunological Approach to the Identification of Cell Adhesion Molecules

    V. Lectins in Cell Adhesion

    VI. Summary

    References

    7. The Organization and Expression of the Dictyostelium Genome

    I. Introduction

    II. General Properties of Genome Structure

    III. General Patterns of mRNA Transcription and Maturation

    IV. Genes Encoding Abundant Stable RNAs

    V. Patterns of Developmental Gene Expression

    VI. Actin Multigene Family

    VII. Discoidin I Multigene Family

    VIII. Transcription of Short, Interspersed Repeat Sequences

    IX. Sequences Common to the 5'-Ends of Dictyostelium Genes

    X. RNA Polymerases and Transcription in Isolated Nuclei

    XI. DNA-Mediated Transformation

    XII. Conclusions and Perspectives

    References

    8. Control of Gene Expression

    I. Developmental Changes in Gene Expression

    II. The Number of Developmentally Regulated Genes

    III. Appearance of Aggregation-Stage mRNAs Is under Transcriptional Control

    IV. Stability of mRNAs during Differentiation

    V. Requirement for Induction of Aggregation-Dependent mRNAs

    VI. Gene Expression Is Dependent on Continued Cell — Cell Interactions

    VII. cAMP and Gene Expression during Differentiation

    VIII. Conclusion

    References

    9. Morphogenetic Signaling, Cytodifferentiation, and Gene Expression

    I. Introduction

    II. Cell Contact-Mediated Signaling

    III. Positional Signaling

    IV. Holistic Signaling

    V. A Unified Theory of Morphogenesis and Cytodifferentiation

    References

    10. Polysphondylium and Dependent Sequences

    I. Introduction

    II. Morphogenesis

    III. Pallidin

    IV. Microcysts

    V. Dependent Pathways

    VI. Commitment

    VII. Prospects

    References

    11. Cell Proportioning and Pattern Formation

    I. Introduction

    II. The Spatial Pattern

    III. The Role of the Slug Pattern in Terminal Differentiation

    IV. Cell Sorting

    V. Diffusible Substances That May Control Differentiation

    VI. Theories of Cell Proportioning and Pattern Formation

    VII. Summary

    References

    Bibliography on Dictyostelium

    Index






Product details

  • No. of pages: 570
  • Language: English
  • Copyright: © Academic Press 1982
  • Published: January 28, 1982
  • Imprint: Academic Press
  • eBook ISBN: 9780323145664

About the Editor

William Loomis

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