The Design and Synthesis of Antimalarial Agents is a comprehensive yet accessible guide for all those involved in the design, development and administration of antimalarial drugs. The book aims to support medicinal chemists in the search for improved and novel antimalarial drugs, providing practical guidance on current developments and highlighting promising leads. Beginning with a focus on biological aspects of malaria, early chapters include a description of the lifecycle of the parasite responsible for malaria, the problem of resistance, combinational therapy, genetic mapping of the parasite’s genome, established drug targets, and potential drug targets for the future.
Malaria is a deadly disease which threatens half of the world’s population. Advances over the last decade have seen vast improvements in the effectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential.
The Design and Synthesis of Antimalarial Agents covers the medicinal chemistry of antimalarial agents in detail, with a focus on the design of antimalarial drugs supported by a review of the drug categories that have reached the market, as well as those in the pipeline. Finally, the synthesis of different classes of antimalarial agents is reviewed, including a discussion on chemical and process development.
- Consolidates current developments in the discovery, design, and synthesis of antimalarial drugs for the first time
- Presents content in a style that is both thorough and engaging, supporting and encouraging students and researchers from interdisciplinary backgrounds
- Highlights which drug targets are currently considered to be the most promising for future therapies, and the classes of compounds that are currently being studied and perfected
Medicinal Chemists; Malaria researchers; Pharmaceutical Scientists; Graduates and academic researchers
1. Historical overview of malaria and its treatment
2. Knowing one’s enemy: Microbiology, genetics, life cycle and resistance mechanisms of the parasite
3. Drug targets and their rationale
4. Testing procedures
5. The cinchona alkaloids and the aminoquinolines
6. Artemisinin and artemisinin-related agents
7. Agents acting on pyrimidine metabolism (triazolopyrimidines)
8. Agents inhibiting haemoglobin hydrolysis (pyrimidine carbonitriles)
10. Drugs targeting mitochondrial functions
11. Miscellaneous agents
12. Bio inorganic agents
13. Synthesis of aminoquinolines
14. Synthesis of artemisinin and related structures
15. Synthesis of other antimalarial agents
- No. of pages:
- © Elsevier 2019
- 1st September 2018
- Paperback ISBN:
Dr. Patrick gained his BSc Honours at Glasgow University, winning the McKay-Smith Prize for Chemistry. He completed his PhD with Professor Kirby and Professor Robins studying the biosynthesis of gliotoxin and related fungal metabolites. Following this, he was employed in the pharmaceutical industry as a research chemist and radiochemist working on a variety of projects that included topic areas such as opioids, antibacterial agents and antidepressants.
His academic career has included positions at Leeds and Strathclyde Universities as well as the Australian National University. He joined the University of the West of Scotland in 1990 and has written a number of scientific books, which have an international reputation. An associate lecturer for the Open University with a particular interest in developing novel teaching techniques, Dr. Patrick is also a Member of the Royal Society of Chemistry, and a Fellow of the Higher Education Academy.
Lecturer, University of the West of Scotland, UK