The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications

The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications

1st Edition - September 11, 2007

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  • Editor: Helen Scharfman
  • eBook ISBN: 9780080551753

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The dentate gyrus is a part of the brain that has been a topic of intense interest since the beginning of neuroscience, and pioneering studies from the distant and recent past attest to this. One of the reasons for such interest is that this structure provides some of the most remarkable examples of plasticity within the nervous system. In addition, it is critical to normal cognitive function, although exactly how and when is still a question that eludes answers. Furthermore, abnormalities within the dentate gyrus appear to play a role in diverse clinical conditions, from depression to epilepsy and traumatic brain injury. The primary goal of this book is to provide a context, or background, upon which the detailed knowledge of the current era can be appreciated. A series of overviews are provided to clarify essentials related to structural organization and development, cellular components, neurotransmitters and neuromodulators, plasticity, and clinical relevance.

Key Features

* Covers the topic comprehensively from anatomy to cellular and systems perspectives
* Includes basic research and addresses translational implications, so it will be useful to both researchers in the laboratory and clinicians who conduct experiments in humans
* Chapters provide fundamentals, but also details and ample references for further review of the topic


Neuroscientists, neurologists, neuroendocrinologists, neuropharmacologists and psychologists.

Table of Contents

  • Section I. Functional Organization and Development.
    1. Intrinsic.
    2. Comparative anatomy of the hippocampal dentat gyrus in adult and developing rodents, non-human primates and humans.
    3. The perforant path: projections from the entorhinal cortex to the dentate gyrus.
    4. Extrinsic afferent systems to the dentate gyrus.
    5. The mossy fibers.
    6. Mossy fiber synaptic transmission: communicating from dentate gyrus to area CA3.
    7. Development of cell and fiber layers in the dentate gyrus.
    8. Genetic regulation of dentate gyrus morphogenesis.

    Section II. Cellular Analyses.
    9. Ultrastructure and synaptic connectivity of cell types in the adult rat dentate gyrus.
    10. Morphological development and maturation of granule neuron dendrites in the rate dentate gyrus.
    11. Physiological studies of human dentate granule cells.
    12. Hilar mossy cells: functional identification and activity in vivo.
    13. Interneurons of the dentate gyrus: an overview of cell types, terminal fields and neurochemical identity.

    Section III. Neurotransmitters and Neuromodulators.
    14. Functional regulation of the dentate gyrus by GABA-mediated inhibition.
    15. Opioid systems in the dentate gyrus.
    16. Somatostatin in the dentate gyrus.
    17. Neuropeptide Y in the dentate gyrus.
    18. Norepinephrine and the dentate gyrus.
    19. Endocannabinoids in the dentate gyrus.
    20. Pro-inflammatory cytokines and their effects in the dentate gyrus.
    21. Role of corticosteroid hormones in the dentate gyrus.
    22. Neurotrophins.
    23. Sex steroids and the dentate gyrus.

    Section IV. Plasticity.
    24. Platic processes in the dentate gyrus: a computational perspective.
    25. Control of synaptic consolidation in the dentate gyrus: mechanisms, functions, and therapeutic implications.
    26. Comparison of cellular mechanisms of long-term depression of synaptic strength at perforant path-granule cell and Schaffer collateral-CA1 synapses.
    27. Structural reorganization of the dentate gyrus following entorhinal denervation - species differences between rat and mouse.
    28. Adult neurogenesis in the intact and epileptic dentate gyrus.
    29. Unmasking recurrent excitation generated by mossy fiber sprouting in the dentate gyrus: an emergent property of a complex system.

    Section V. The Dentate Gyrus Network.
    30. A behavioural analysis of dentate gyrus function.
    31. Unmasking recurrent excitation generated by mossy fiber sprouting in the epileptic dentate gyrus: an emergent property of a complex system .
    32. The dentate gyrus as a filter or gate: a look back and a look ahead.
    33. Role of the dual entorhinal inputs to hippocampus: a hypothesis based on cue/action (non-self/self) couplets.

Product details

  • No. of pages: 840
  • Language: English
  • Copyright: © Elsevier Science 2007
  • Published: September 11, 2007
  • Imprint: Elsevier Science
  • eBook ISBN: 9780080551753

About the Editor

Helen Scharfman

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