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The Cytokines of the Immune System - 1st Edition - ISBN: 9780124199989, 9780124200104

The Cytokines of the Immune System

1st Edition

The Role of Cytokines in Disease Related to Immune Response

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Author: Zlatko Dembic
Paperback ISBN: 9780124199989
eBook ISBN: 9780124200104
Imprint: Academic Press
Published Date: 2nd June 2015
Page Count: 320
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The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles.

Key Features

  • Supplies new ideas for basic and clinical research
  • Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials
  • Offers a textbook-style view on the immune system with the immunologic role of each cytokine


graduate students to scientists, researchers, teachers in microbiology, immunology, biochemistry, cell biology, medicine, cytokine biology, and odontology: clinicians in all specialties of medicine and surgery: pharmaceutical companies and their R&D divisions.

Table of Contents

  • Foreword
  • Acknowledgments
  • Chapter 1. Introduction—Common Features About Cytokines
    • Division
    • Structure
    • Receptors
    • Intracellular Signal Transduction
    • Hormones and Cytokines
    • Function
  • Chapter 2. The Immune System—Definition and Development of Immunity
    • Organization of the Immune System
    • Humoral Innate (Nonspecific) Immunity
    • Cellular Innate (Nonspecific) Immunity
    • Adaptive Humoral (Specific) Immune System
    • Cellular Adaptive (Specific) Immune System
  • Chapter 3. Activation of Cells of the Immune System
    • Activation of Immune Cells in the Periphery of the Immune System
    • Specific Recognition
    • Coreceptors of T Cells: CD4 and CD8
    • Costimulation During T-Cell Activation
    • Signal Transduction in T Cell
    • Signal Transduction in the B Cell
    • Signal Transduction in Mast Cells
    • Further Development of Immune Cells Upon Activation
    • T lymphocyte homeostasis
    • Repertoire and Tolerance
  • Chapter 4. The Role and Regulation of the Immune Responses
    • The Course of the Immune Response
    • Regulation of Immunocyte Development after Activation
    • Important Control Functions of Cytokines
    • The Role of Th1-Type of Immune Response
    • The Role of Th2-Type of Immune Response
    • The Role of Th9 Subset
    • The Role of Th17 Subset
    • The Role of Th22 Subset
    • The Role of Th3, and Tr1 Cells
    • The Role of Regulatory CD4 T Lymphocytes—Tregs
    • The Role of the Tfh Subset
  • Chapter 5. Cytokines of the Immune System: Interferons
    • Interferon-α/β
    • Interferon-γ (IFN-γ)
    • Interferon-λ (IFN-λ)
  • Chapter 6. Cytokines of the Immune System: Interleukins
    • IL-1
    • IL-2
    • IL-3
    • IL-4
    • IL-5
    • IL-6
    • IL-7
    • IL-8
    • IL-9
    • IL-10
    • IL-11
    • IL-12
    • IL-13
    • IL-14 (IL-14 does not exist in databases)
    • IL-15
    • IL-16
    • IL-17
    • IL-18
    • IL-19
    • IL-20
    • IL-21
    • IL-22
    • IL-23
    • IL-24
    • IL-25
    • IL-26
    • IL-27
    • IL-28 and IL-29 (Type III Interferon, λ1–3)
    • IL-30
    • IL-31
    • IL-32
    • IL-33
    • IL-34
    • IL-35
    • IL-36
    • IL-37
    • IL-38
  • Chapter 7. Cytokines of the Immune System: Chemokines
    • About Chemokines
    • The Role of Chemokines in the Immune System
    • CCL Chemokines (CCL1–CCL28)
    • CXCL Chemokines (1–16)
    • CX3CL Chemokine
    • XCL Chemokines (1–2)
    • Other Features of Chemokines
  • Chapter 8. Cytokines Important for Growth and/or Development of Cells of the Immune System
    • TNF-α/β
    • TGF-β
    • TSLP (Thymic Stromal Lymphopoietin)
    • KGF (Keratinocyte Growth Factor)
    • SCF (Stem Cell Factor) and Growth Factors (CSF, GM-CSF, M-CSF) of Hematopoietic Lines
    • LIF—Leukemia Inhibitory Factor
    • CNTF—Ciliary Neurotrophic Factor
    • OSM—Oncostatin M
    • A Short Description of Other Cytokines that Regulate Growth and Development of Various Tissues
  • Chapter 9. Theories about the Function of the Immune System
    • About Scientific Theories
    • Self–Nonself Discrimination
    • The “Pathogen-Associated Molecular Pattern (Pamp) Recognition” Theory (Janeway)
    • Idiotypic Networks and Suppression (Jerne)
    • The “Danger” Model (Matzinger)
    • The “Integrity” Model (Dembic)
    • Other Theories About Immunity
  • Index


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© Academic Press 2015
2nd June 2015
Academic Press
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About the Author

Zlatko Dembic

Zlatko Dembic

As a scientist and a medical doctor, Dr. Dembic’s research interests are at the crossroads of medicine and biology, related to molecular and cellular immunology. During the last twenty years of the past century he’s worked on important issues in immunology at the Max-Planck-Institute for Biology (Tubingen, Germany), the Basel Institute for Immunology (Switzerland; CH) and the Hoffman-La Roche AG (Basel, CH). His team was the first to report the identification of genes underlying T-cell specificity and recognition (mouse T-cell receptor, in '86, Nature). Likewise, his team led the research on molecular cloning of human cytokine receptors important for the effector phase of immunity such as the interferon-gamma receptor (IFNGR1; in '88, Cell) and the tumor necrosis factor receptor-2 (TNFR2; in '90, Cytokine).

In 1995, Dr. Dembic moved to the Institute of Immunology at the University of Oslo, Norway. Since then he broadened the scope of his research by working on T-cell development, cancer immunobiology, immunogenetics and susceptibility to cancer and infectious diseases. All of this would not have been possible without a substantial contribution from his academic collaborators and colleagues internationally, and especially in Norway and Croatia. Some of these studies led him to propose a model about the workings of the immune system called the "integrity" model in the mid-nineties. It stresses that immunity is not only a defense system, but also a selector of potential symbionts and commensals. The use of soluble mediators (cytokines) in communication between immune cells is perhaps only in part similar to neural networks, as interacting cells constitute mobile units within the body.

Dr. Dembic’s publication list has over 80 scientific contributions. Ten percent were published in high impact factor scientific journals (Nature, Cell etc) with himself as a prominent author (in half of them). Perhaps, they stand as a witness of delight that he had by doing scientific research.

Affiliations and Expertise

Professor of Immunology, Cell Biology, and Microbiology, University of Oslo, Department of Oral Biology, Norway

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