The Control of Fertility

The Control of Fertility is concerned with the experimental control of fertility as a specific biological problem. It is, first of all, an attempt to summarize a collection of data hitherto either partially or not at all presented. Secondly, it attempts to indicate those avenues which hold promise for future investigation. Finally, it attempts an assessment of the implications of understandings and ignorances.
The book opens with an account of the sequence of processes essential to successful sexual reproduction in mammals. This is followed by separate chapters on approaches to the inhibition of spermatogenesis, ovulation, fertilization, and free ovum development. Subsequent chapters deal with blastocyst development and implantation, biological activities of compounds affecting fertility, fertility control in men and women, the inhibition of ovulation, biological properties of ovulation inhibitors in human subjects, and effectiveness and acceptability of contraception.

Preface

Acknowledgments

I. Introduction

1. Backgrounds

Text

References

2. The Reproductive Processes and Their Vulnerabilities in Mammals

Processes in the Male

Processes in the Female

References

II Animal Studies

3. Spermatogenesis and Semen

Pituitary and Gonadotropin Inhibition

Direct Effects on Testis Tissue

Semen and Seminal Fluid

References

4. Ovulation

The Hypothalamopituitary Axis

Steroidal Ovulation Inhibitors

Antigonadotropin Assay

Antigonadotropins and the Hypothalamus

Inhibition of Exogenous Gonadotropin

Miscellaneous Antigondotropic Agents

References

5. Fertilization

Text

References

6. Free Ovum Development

Text

References

7. Blastocyst Development and Implantation

Ovarian Hormones and Implantation Processes

Extra-Ovarian Influences on Implantation

The Lability of Implantation Processes

Estrogens and Anti-Estrogens

Antiprogestins

Poisons and Antimetabolites

Intrauterine Trauma

Corpus Luteum Inhibition

Abortion

References

8. Some Biological Activities of Compounds Affecting Fertility

Some Activities of Estrogens

Anti-Estrogens

Estrogens and Androgens

The Activities of Gestagens

Effects on Fetuses

Hormones and Tumors

The Metabolism of Compounds Affecting Fertility

References

III Clinical Studies

9. Control of Fertility in Men

Text

References

10. Fertility in Women—Ovogenesis and Ovulation

Fertility Potential in Women

Detection of Ovulation

The Stimulation of Ovulation

References

11. The Inhibition of Ovulation

The Assay of Ovulation Inhibitors in Human Subjects

Contraception

References

12. Some Biological Properties of Ovulation Inhibitors in Human Subject

Functions Associated with Reproductive Organs and Processes

Mammary Glands and Lactation

Pregnancy and Postpartum

Functions Associated with Other Endocrine Organs

Effects on Somatic Tissues and Functions

Weight Gain and Aspects of Organic Metabolism

Hematology

Skin and Related Tissues

Psychological Effects

References

13. Some Consequences of the Application of Fertility Control

The Effectiveness of Contraception

The Acceptability of Contraception

References

Author Index

Subject Index