Description

This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates.

Key Features

* Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France * 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology * Includes the major toxins of both basic and clinical interest are described in depth * Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology * Evolutionary and functional aspects of bacterial toxins evaluated and summarized * Toxin applications in cell biology presented * Therapy (cancer therapy, dystonias) discussed * Vaccines (native and genetically engineered vaccines) featured * Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.

Readership

Researchers, Academics, Graduate Students and PhD's in general microbiology, clinical microbiology and infectious disease

Table of Contents

Introduction A 116-year story of bacterial protein toxins (1888-2004): From 'diphtheritic poison' to molecular toxinology Evolutionary aspects of toxin-producing bacteria Mobile genetic elements and pathogenicity islands encoding bacterial toxins Regulation systems of toxin expression Toxin secretion systems Intracellular trafficking of bacterial protein toxins Translocation of bacterial protein toxin into the cytosol Bacterial toxins and virulence factors targeting the actin cytoskeleton and intracellular junctions Bacterial toxins and mitochondria Toxins activating RHO GTPases and exploiting the cellular ubiquitin/proteasome machineries Toxin receptors Molecular, functional and evolutionary aspects of ADP-ribosylating toxins Diphtheria toxin Attack of the nervous system by clostridial toxins: Physical findings, cellular and molecular actions Uptake and transport of clostridial neurotoxins Bacillus anthracis toxins Large clostridial cytotoxins modifying small GTPases Bordetella protein toxins Vibrio Cholerae and Escherichia Coli thermolabile enterotoxin The Shiga toxins: Properties and action on cells Helicobacter pylori vacuolating toxin Pasteurella multocida toxin Cytolethal distending toxins Pseudomonas aeruginosa toxins Escherichia coli heat- stable enterotoxin b Paradigms and classification of bacterial membrane -damaging toxins Membrane damaging and cytotoxic phospholipases Bacteroides fragilis toxins Structure and mode of action of RTX cytolysins Genetics and phylogeny of RTX cytolysins

Details

No. of pages:
1072
Language:
English
Copyright:
© 2006
Published:
Imprint:
Academic Press
Print ISBN:
9780120884452
Electronic ISBN:
9780080456980

About the authors

Joseph Alouf

Joseph E. Alouf is Professor of Microbiology at the Pasteur Institute of Lille. He is former Head of the Department of Bacteriology and Mycology at the Pasteur Institute at Paris and Chairman of its Scientific Council. He served as Secretary General of the French Society of Immunology from 1984-1986 and President of the Federation of the European Microbiological Societies from 1989-1992. His 40-year research work relates to the field of bacterial protein toxins and immunology of infectious diseases. He is also the co-editor of several books.

Michel Popoff

Michel R. Popoff, D.V.M., Ph.D. (Microbiology) from the University of Paris (1985), Habilitation à Diriger des Recherches (HDR) from the University of Paris (1990), is the Head of the Anaerobic Bacteria and Toxins Unit and the Director of the National Reference Center for Anaerobic Bacteria and Botulism at Pasteur Institute, Paris, France. He is member of the French Veterinary Academy. His laboratory is focused on Clostridium toxins through genetic and biological activity analysis and has investigated the regulation of toxin synthesis in Clostridium botulinum and Clostridium tetani. In the recent years, we have analyzed the molecular mechanism of the actin depolymerizing C. sordellii lethal toxin and clostridial binary toxins, the pore-forming C. perfringens epsilon toxin, and the passage of botulinum neurotoxin through the intestinal barrier. He was co-editor of the 3° edition of the Sourcebook of Bacterial Protein Toxins Academic Press (2006).

Reviews

“The title of this book says it all – this volume is encyclopedic, thorough, and as complete as any book of this type could be. …This book is a pièce de résistance. The editors are to be congratulated on producing a revised edition with vitality. They have successfully met all of the challenges posed in knitting diverse contributions together. The Comprehensive Sourcebook of Bacterial Protein Toxins will be an authoritative reference work for many years. Every medical school and university library must have a copy. For the individual purchaser, it will be a worthwhile investment and a treasure trove of information.” - Cyril J. Smith, Trinity College Dublin, Ireland for CLINICAL INFECTIOUS DISEASES (Sept 2006) "Doody's 3 Star Review: This book presents an overview of current approaches to protein structure prediction. Beginning with very basic concepts, there is a transition to modern methods with a strong (and logical) emphasis on computational approaches...This book offers a comprehensive introduction to the techniques commonly employed in [the] field...This is a concise, well written overview of the field. More technical manuals are available and there is a great deal of primary literature. Nonetheless, this book is of substantial value to younger scientists." - Eugene A Davidson, PhD, Georgetown University School of Medicine (2006)