The Complement FactsBook

1st Edition

Authors: Scott Barnum Bernard Morley Mark Walport
Paperback ISBN: 9780127333601
eBook ISBN: 9780080529554
Imprint: Academic Press
Published Date: 28th October 1999
Page Count: 240
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Table of Contents

Abbreviations. Preface. Section 1: The Introductory Chapters B.J. Morley and M. Walport, Introduction. B.J. Morely and M. Walport, The Complement System. Section II: The Complement Proteins Part 1: C1q and the Collectins F. Petry and M. Loos, C1q. P. Lawson and K.B.M. Reid, Mannose-binding Lectin. P. Lawson and K.B.M. Reid, Bovine Conglutinin. R.B. Sim, SP-A. R.B. Sim, SP-D. Part 2: Serine Proteases N. Thielens and G.J. Arlaud, C1r. N. Thielens and G.J. Arlaud, C1s. T. Fujita, MASP-1. S. Petersen and J. Jensenius, MASP-2. J. Schifferli and S. Niot, Factor D. Y. Xu Ma and J.E. Volanakis, C2. A. Circolo and H.R. Colten, Factor B. B.J. Morley, Factor I. Part 3: C3 Family M. Botto, C3. R.A. Wetsel, C5. Part 4: Terminal Pathway Components M. Hobart, C6. M. Hobart, C7. F. Tedesco, M.E. Plumb, and J.M. Sodetz, C8. B.P. Morgan, C9. Part 5: Regulations of Complement Activation (RCA) L.B. Klickstein, CR1. J.M. Guthridge and V.M. Holers, CR2. L. Kuttner-Kondo, W.G. Brodbeck, and M.E. Medof, Decay-accelerating Factor. M.K. Liszewski and J.P. Atkinson, Membrane Cofactor Protein. S. Rodriguez de Cordoba, O. Criado Garcia, and P. Sanchez-Corral, C4b-binding Protein. R.G. DiScipio


The Complement FactsBook contains entries on all components of the Complement System, including C1q and Lectins, C3 Family, Serine Proteases, Serum Regulators of Complement Activation, Cell Surface Proteins, and Terminal Pathway Proteins. Domain Structure diagrams are incorporated to clearly illustrate the relationships between all the complement proteins, both within families and between families. The FactsBook also includes the cDNA sequences, marked with intron/exon boundaries, which will facilitate genetic studies.

Key Features

@introbul:Key Features @bul:* Includes the cDNA sequences, marked with intron/exon boundaries, facilitating genetic studies

  • Presents detailed structural information including cDNA and gene structure for all proteins
  • Introduces complement function, simply described for each function
  • Data is as up-to-date as possible, including unpublished work from many contributors
  • Incorporates domain structures diagrams, which beautifully illustrate the relationship between all the complement proteins, both within, and between, families
  • Each chapter has been written by an expert in the field
  • Data is as up-to-date as possible, including unpublished work from many contributors @introbul:Entries provide information on: @bul:* Alternative nomenclature
  • Physiochemical properties
  • Structure and function
  • Tissue distribution and regulation expression
  • Protein sequence/modules
  • Chromosomal location
  • Genomic structure
  • Database accession numbers
  • Deficiency and polymorphic variants
  • Key references


Basic researchers and clinicians in immunology, biochemistry, cell biology, and infectious diseases; anyone interested in the complement system.


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© Academic Press 2000
Academic Press
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About the Authors

Scott Barnum Author

Scott R. Barnum (b. 1957), Professor of Microbiology, (secondary appointments in Neurology and Rheumatology) completed undergraduate studies in biology at Loyola College in Baltimore (B.S., cum laude, 1979). He completed his graduate studies at the University of Alabama at Birmingham (Ph.D., Microbiology, 1985) on the biosynthesis and catabolism of complement factor D. Postdoctoral studies were pursued at the Research Institute of Scripps Clinic on the genomic organization of several complement genes. He joined the UAB faculty in 1989, where studies examining the production and regulation of complement in the central nervous system were initiated. He has an extensive background in complement biology that covers studies on over a dozen of the proteins, numerous mutant and transgenic mice and animal and human studies. He is member of the American Association to for Advancement of Science, American Association of Immunologists, American Society of Neurochemistry, International Complement Society and the international society of neuroimmunology.

Affiliations and Expertise

Professor of Microbiology, University of The University of Alabama School of Medicine, Birmingham, AL, USA

Bernard Morley Author

Dr. Bernard Morely is a senior lecturer in the Division of Medicine of the Imperial College School of Medicine. He studied biochemistry at Liverpool University before training for his doctorate at Oxford in the late Dr. Rodney Porter's unit. Here he worked on cloning Factor B with Duncan Campbell. After several years of work in the USA and the UK on globin expression and its regulation, he returned to complement research at the Hammersmith Hospital. His present research interests are in the genetics of SLE and the regulation of gene expression.

Affiliations and Expertise

Imperial College School of Medicine, London, U.K.

Mark Walport Author

Professor Mark Walport is a professor of medicine and the head of the Division of Medicine at Imperial College School of Medicine. He was previously Director of Research and Development fot the Hammersmith Hospitals Trusts. He trained at Cambridge University and the Middlesex Hospital Medical School. After junior clinical training posts, he undertook a Ph.D. in Cambridge supervised by Professor Peter Lachmann. From there he moved in 1985 to the Royal Postgraduate Medical School at Hammersmith Hospital. His research interests are in the genetics of the complement system and in the inherited mechanisms of susceptibility to autoimmune rheumatic diseases.

Affiliations and Expertise

Imperial College School of Medicine, London, U.K.